Search results for "CKS"

A poorly differentiated synovial sarcoma (SYT/SSX1) expresses neuroectodermal markers: a xenografts and in vitro culture study.

2004

Synovial sarcoma (SS) is a neoplasm that poses diagnostic problems, due to its histologic heterogeneity. The poorly differentiated variant, in particular, may be histologically indistinguishable from other small round cell tumors. Detection of the synovial sarcoma-associated t(X;18) or SYT-SSX fusion transcripts may be necessary to confirm the diagnosis of SS in difficult cases. Most of SS carry a t(X;18) in about one third of cases as the sole cytogenetic abnormality. We evaluated a case of poorly differentiated synovial sarcoma and their derived tumors in nude mice xenografts and cell cultures. We used a panel of antibodies (including those to intermediate filament, nerve-sheath associate…

Vitamin B1 Intake in Multiple Sclerosis Patients and its Impact on Depression Presence: A Pilot Study

2020

Vitamin B1, or thiamine, is one of the most relevant vitamins in obtaining energy for the nervous system. Thiamine deficiency or lack of activity causes neurological manifestations, especially symptoms of depression, intrinsic to multiple sclerosis (MS) and related to its pathogenesis. On this basis, the aim of this study was to determine the possible relationship between the nutritional habits of patients with MS and the presence of depression. Therefore, a cross-sectional and observational descriptive study was conducted. An analysis of dietary habits and vitamin B1 consumption in a Spanish population of 51 MS patients was performed by recording the frequency of food consumption. Results …

Chocolate Consumption and Indicators of Adiposity in US Adults.

2020

International audience; Purpose: The purpose of this research is to investigate the association between consumption of chocolate and measures of adiposity in a large, representative sample of US adults. Methods: Cross-sectional data from 13,626 nondiabetic adults (≥20 years) participating in the National Health and Nutrition Examination Survey study were aggregated using 5 study cycles from 2005-2006 through 2013-2014. Chocolate consumption was determined based on 2 24-hour dietary recalls. Body mass index (BMI) and waist circumference were objectively measured. We used multivariable linear regression to test associations of 1) any chocolate consumption (yes/no), and 2) the total amount of …

Risk Factors for Classical Kaposi Sarcoma in a Population-based Case-control Study in Sicily

2008

Abstract Background: Classical Kaposi sarcoma is a rare complication of Kaposi sarcoma-associated herpes virus (KSHV) infection. We conducted a population-based, frequency-matched case-control study in Sicily to further investigate the reported inverse relationship between smoking and classical Kaposi sarcoma and to identify other factors associated with altered risk. Methods: All incident, histologically confirmed classical Kaposi sarcoma cases in Sicily were eligible. A two-stage cluster sample design was applied to select population controls. KSHV seropositivity was determined using four antibody assays (K8.1 and orf73 enzyme immunoassays and two immunofluorenscence assays). Using SAS-ca…

Is there a relationship between chocolate consumption and symptoms of depression? A cross-sectional survey of 13,626 US adults

2019

Objective: To examine associations between chocolate consumption and depressive symptoms in a large, representative sample of US adults. Methods: The data were from 13,626 adults (≥20 years) participating in the National Health and Nutrition Examination Survey between 2007–08 and 2013–14. Daily chocolate consumption was derived from two 24-hr dietary recalls. Depressive symptoms were assessed using the Patient Health Questionnaire (PHQ-9), with scores ≥10 indicating the presence of clinically relevant symptoms. We used multivariable logistic regression to test associations of chocolate consumption (no chocolate, non-dark chocolate, dark chocolate) and amount of chocolate consumption (grams/…

Cytoskeletal Heterogeneity of an Epithelioid Sarcoma with Expression of Vimentin, Cytokeratins, and Neurofilaments

1990

We studied an unusual sarcoma with morphologic features diagnostic of epithelioid sarcoma by conventional light microscopy, transmission electron microscopy, and immunohistochemistry. The primary tumor, which was located in the deep soft tissues of the buttock of a 32-year-old woman, and its metastases to lymph nodes, liver, and lung were available for investigation. The histomorphological and ultrastructural appearance of the primary tumor and its metastatic deposits were typical of epithelioid sarcoma. Immunohistochemistry revealed a strong and uniform reactivity for vimentin in both the primary tumor and its metastases. In contrast, a marked cytoskeletal heterogeneity became evident for …

Climatology of the aerosol extinction-to-backscatter ratio from sun-photometric measurements

2010

The elastic lidar equation contains two unknown atmospheric parameters, namely, the particulate optical extinction and backscatter coefficients, which are related through the lidar ratio (i.e., the particulate-extinction-to-backscatter ratio). So far, independent inversion of the lidar signal has been carried out by means of Raman lidars (usually limited to nighttime measurements), high-spectral-resolution lidars, or scanning elastic lidars under the assumption of a homogeneously vertically stratified atmosphere. In this paper, we present a procedure to obtain the lidar ratio at 532 nm by a combined Sunphotometer– aerosol-model inversion, where the viability of the solution is largely reinf…

Aerosol Lidar Intercomparison in the Framework of SPALINET—The Spanish Lidar Network: Methodology and Results

2009

Abstract—A group of eight Spanish lidars was formed in order to extend the European Aerosol Research Lidar Network–Advanced Sustainable Observation System (EARLINET-ASOS)project. This study presents intercomparisons at the hardware and software levels. Results of the system intercomparisons are based on range-square-corrected signals in cases where the lidars viewed the same atmospheres. Comparisons were also made for aeros backscatter coefficients at 1064 nm (2 systems) and 532 nm (all systems), and for extinction coefficients at 532 nm (2 systems). In total, three field campaigns were carried out between 2006 and 2007. Comparisons were limited to the highest layer found before the free tr…

A pigmented and eroded lesion on the buttock.

2019

Biological clocks and physical functioning in monozygotic female twins

2018

Background Biomarkers of biological aging – DNA methylation age (DNAm age) and leukocyte telomere length (LTL)– correlate strongly with chronological age across the life course. It is, however, unclear how these measures of cellular wear and tear are associated with muscle strength and functional capacity, which are known to decline with older age and are associated with mortality. We investigated if DNAm age and LTL were associated with body composition and physical functioning by examining 48 monozygotic twin sisters. Methods White blood cell DNAm age (predicted years) was calculated from Illumina 450 k BeadChip methylation data using an online calculator. DNAm age acceleration was define…