Search results for "CLL"

Eurofusion-DEMO Divertor - Cassette Design and Integration

2020

International audience; The Eurofusion-DEMO design will complete the Pre Conceptual Design phase (PCD) with a PCD Gate, named G1, scheduled to take place in Q4 2020 that will focus on assessing the feasibility of the plant and its main components prior to entering into the Conceptual Design phase. In the paper first an overview is given of the Eurofusion-DEMO Divertor Assembly including design and interface description, systems and functional requirements, load specification, system classification, manufacturing procedures and cost estimate. Then critical issues are discussed and potential design solutions are proposed, e.g.:- Neutron material damage limits of the different (structural) mat…

On the effects of the Double-Walled Tubes lay-out on the DEMO WCLL breeding blanket module thermal behavior

2019

Abstract The EU-DEMO Water-Cooled Lithium Lead Breeding Blanket (WCLL BB) concept foresees liquid Pb-15.7Li eutectic alloy as breeder and neutron multiplier, whereas pressurized subcooled water as coolant, with operative conditions typical of the PWR fission reactors (temperature in the range of 295–328 °C and pressure of 15.5 MPa). The cooling down of the BB is guaranteed by means of two separated cooling circuits: the one consisted in square channels housed within the complex of Side Walls and First Wall, and the one composed of a set of Double-Walled Tubes (DWTs) submerged in the Breeding Zone (BZ) and deputed to remove heat power therein generated. A parametric thermal study has been ca…

Parametric study of the influence of double-walled tubes layout on the DEMO WCLL breeding blanket thermal performances

2020

Abstract Within the framework of the EUROfusion activities regarding the EU-DEMO Breeding Blanket (BB) concept, the University of Palermo is long-time involved, in close cooperation with ENEA, in the design of the Water Cooled Lithium Lead (WCLL) BB, that is one of the two concepts under consideration for the DEMO reactor. It is mainly characterized by a liquid lithium-lead eutectic alloy acting as breeder and neutron multiplier, as well as by subcooled pressurized water flowing as coolant under PWR-like conditions (pressure of 15.5 MPa and inlet/outlet temperatures of 295 °C/328 °C). A research campaign has been recently carried out to study the potential influence of the Breeding Zone coo…

Thermo-Mechanical Analysis and Design Update of the Top Cap Region of the DEMO Water-Cooled Lithium Lead Central Outboard Blanket Segment

2022

Within the framework of the EUROfusion research and development activities, the Water-Cooled Lithium Lead (WCLL) Breeding Blanket (BB) is one of the two candidates to be chosen as the driver blanket for the European DEMO nuclear fusion reactor. Hence, an intense research work is currently ongoing throughout the EU to develop a robust conceptual design able to fulfil the design requirements selected at the end of the DEMO pre-conceptual design phase. In this work, the thermo-mechanical analysis and the design update of the top cap (TC) region of the DEMO WCLL Central Out-board Blanket (COB) segment is presented. The scope of the work is to find a design solution of the WCLL COB TC region abl…

Analysis of the Thermo-Mechanical Behaviour of the EU DEMO Water-Cooled Lithium Lead Central Outboard Blanket Segment under an Optimized Thermal Field

2022

Within the framework of the EUROfusion research activities on the DEMO Water-Cooled Lithium Lead (WCLL) Breeding Blanket (BB) design, a research study was performed to preliminarily optimize, from the thermal point of view, the WCLL Central Outboard Blanket (COB) segment in order to investigate its structural behaviour under a realistic thermal field. In particular, a study of thermal analyses was performed to optimize the Double Walled Tubes and Segment Box cooling channels’ geometric configurations along the poloidal extension of the WCLL COB segment, in order to obtain a spatial temperature distribution fulfilling the thermal design requirement. Then, the thermo-mechanical analysis of th…

A Monte Carlo study on the possible lay-out influence in the HCLL-TBM nuclear response

2008

Consensus guidelines for the detection of immunogenic cell death

2014

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we named "immunogenic cell death" (ICD). ICD is preceded or accompanied by the emission of a series of immunostimulatory damage-associated molecular patterns (DAMPs) in a precise spatiotemporal configuration. Several anticancer agents that have been successfully employed in the clinic for decades, including various chemotherapeutics and radiotherapy, can elicit ICD. Moreover, defect…

Quaking and miR-155 interactions in inflammation and leukemogenesis.

2015

Quaking (QKI) is a tumor-suppressor gene encoding a conserved RNA-binding protein, whose expression is downregulated in several solid tumors. Here we report that QKI plays an important role in the immune response and suppression of leukemogenesis. We show that the expression of Qki is reduced in lipopolysaccharide (LPS)-challenged macrophages, suggesting that Qki is a key regulator of LPS signaling pathway. Furthermore, LPS-induced downregulation of Qki expression is miR-155-dependent. Qki overexpression impairs LPS-induced phosphorylation of JNK and particularly p38 MAPKs, in addition to increasing the production of anti-inflammatory cytokine IL-10. In contrast, Qki ablation decreases Fas …

Assessment of the Thermo-mechanical Performances of a DEMO Water-Cooled Liquid Metal Blanket Module

2015

Within the framework of DEMO R&D activities, a research cooperation has been launched between ENEA-Brasimone, CEA-Saclay and the University of Palermo to investigate the thermo-mechanical behaviour of the outboard equatorial module of the DEMO1 Water-Cooled Lithium Lead (WCLL) blanket, both under normal operation and over-pressurization steady state scenarios. The research campaign has been carried out following a theoretical-computational approach based on the finite element method (FEM) and adopting a qualified commercial FEM code. In particular, two different three-dimensional FEM models of the WCLL blanket module have been set-up to be used for normal operation and over-pressurization a…

The cumulative amount of serum-free light chain is a strong prognosticator in chronic lymphocytic leukemia.

2011

AbstractIdentification of patients at risk of early disease progression is the mainstay of tailored management in chronic lymphocytic leukemia (CLL). Although application of established biomarkers is limited by intrinsic detection/readout complexities, abnormality of κ and λ serum-free light chain ratio [sFLC (κ/λ)] was proposed as a straightforward prognosticator in CLL. By analyzing 449 therapy-naive patients, we show that an abnormal sFLC(κ/λ), along with CD38, ZAP-70, IGHV mutations, cytogenetics and stage, independently predicts treatment-free survival (TFS) but becomes prognostically irrelevant if the cumulative amount of clonal and nonclonal FLCs [sFLC(κ + λ)], a variable associated …