Search results for "CLL"
showing 10 items of 73 documents
Baseline Characteristics Predicting Very Good Outcome of Allogeneic Hematopoietic Cell Transplantation in Young Patients With High Cytogenetic Risk C…
2017
Patients with chronic lymphocytic leukemia with del(17p) or del(11q) have poor long-term prognosis with targeted therapies. Conversely, this retrospective European Society for Blood and Marrow Transplantation registry study shows that young high cytogenetic risk responsive patients with human leukocyte antigen-matched donors have a high 8-year progression-free survival and low 2-year non-relapse mortality after allogeneic stem cell transplantation. This treatment then may compare favorably with targeted therapies for younger high cytogenetic risk patients.Background: Patients with genetically high-risk relapsed/refractory chronic lymphocytic leukemia have shorter median progression-free sur…
Thermal–mechanical and thermal–hydraulic integrated study of the Helium-Cooled Lithium Lead Test Blanket Module
2010
Abstract The Helium-Cooled Lithium Lead Test Blanket Module (HCLL-TBM) is one of the two TBM to be installed in an ITER equatorial port since day 1 of operation, with the specific aim to investigate the main concept functionalities and issues such as high efficiency helium cooling, resistance to thermo-mechanical stresses, manufacturing techniques, as well as tritium transport, magneto-hydrodynamics effects and corrosion. In particular, in order to show a DEMO-relevant thermo-mechanical and thermal–hydraulic behavior, the HCLL-TBM has to meet several requirements especially as far as its coolant thermofluid-dynamic conditions and its thermal–mechanical field are concerned. The present paper…
Analysis of the thermo-mechanical behaviour of the DEMO Water-Cooled Lithium Lead breeding blanket module under normal operation steady state conditi…
2015
Within the framework of DEMO R&D activities, a research cooperation has been launched between ENEA, the University of Palermo and CEA to investigate the thermo-mechanical behaviour of the outboard equatorial module of the DEMO1 Water-Cooled Lithium Lead (WCLL) blanket under normal operation steady state scenario. The research campaign has been carried out following a theoretical-computational approach based on the Finite Element Method (FEM) and adopting a qualified commercial FEM code. In particular, two different 3D FEM models (Model 1 and Model 2), reproducing respectively the central and the lateral poloidal-radial slices of the WCLL blanket module, have been set up. A particular attent…
On the thermal and thermomechanical assessment of the “Optimized Conservative” helium-cooled lithium lead breeding blanket concept for DEMO
2018
Abstract Within the framework of EUROfusion R&D activities a research campaign has been performed at CEA-Saclay, in close collaboration with the University of Palermo, in order to investigate thermal and thermomechanical performances of the “Optimized Conservative” concept of DEMO Helium-Cooled Lithium Lead breeding blanket (HCLL). Attention has been paid to the HCLL outboard equatorial module (OEM) when subjected to the steady state nominal loading scenario. To this purpose three simplified 3D models, characterized by an increasing level of detail, have been set-up taking into account, firstly, a single radial-toroidal slice, then a basic module geometric unity composed by two adjacent sli…
Thermal optimization of the Helium-Cooled Lithium Lead breeding zone layout design regarding TBR enhancement
2017
Abstract Within the framework of EUROfusion R&D activities, CEA-Saclay has carried out an investigation of the thermal and mechanical performances of alternative designs intended to enhance the Tritium Breeding Ratio (TBR) of the Helium-Cooled Lithium Lead (HCLL) Breeding Blanket (BB) for DEMO. Neutronic calculations performed on the 2014 DEMO HCLL baseline predicted a value of TBR equal to 1.07, lower than the required value of 1.1, necessary to ensure the tritium self-sufficiency of the breeding blanket taking into account uncertainties. In order to reach the TBR target, the strategy of the steel amount reduction inside the HCLL module breeding zone (BZ) has been followed by suppressing s…
On the effect of stiffening plates configuration on the DEMO Water Cooled Lithium Lead Breeding Blanket module thermo-mechanical behaviour
2019
Abstract Within the framework of the pre-conceptual design of the EU-DEMO Breeding Blanket (BB) supported by EUROfusion action, results of the research activities carried out in the last years have highlighted that changes in the proposed Water Cooled Lithium Lead (WCLL) BB design have to be considered, especially as to the liquid breeder circulation path within the BB module. Therefore, in view of the definition of a final WCLL BB module layout, a parametric campaign of numerical analyses has been carried out at the University of Palermo in order to assess the impact of different SPs configurations on the module thermo-mechanical performances. To this purpose, attention has been focussed o…
Thermo-mechanical analyses and ways of optimization of the helium cooled DEMO First Wall under RCC-MRx rules
2017
Abstract The EUROfusion Consortium develops a design of a fusion power demonstrator plant (DEMO) in the framework of the European “Horizon 2020” innovation and research program. One of the key components in the fusion reactor is the Breeding Blanket (BB) surrounding the plasma, ensuring tritium self-sufficiency, heat removal for conversion into electricity, and neutron shielding. Among the 4 candidates for the DEMO BB, 2 of them use helium as coolant (HCPB, HCLL), and another one (DCLL) uses helium to cool down the First Wall (FW) only. Due to uncertainties regarding the plasma Heat Flux (HF) load the DEMO BB integrated FW will have to cope with, a set of sensitive thermal and stress analys…
SiC-based sandwich material for Flow Channel Inserts in DCLL blankets: Manufacturing, characterization, corrosion tests
2017
This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 under grant agreement No 633053. The views and opinions expressed herein do not necessarily reflect those of the European Commission.
Multi-Module vs. Single-Module concept: Comparison of thermomechanical performances for the DEMO Water-Cooled Lithium Lead breeding blanket
2018
Abstract Within the framework of EUROfusion R&D activity an intense research campaign has been performed at the University of Palermo, in close cooperation with ENEA labs and KIT, in order to compare the thermomechanical performances of the Back Supporting Structure (BSS) of Multi-Module and Single-Module concepts of DEMO Water-Cooled Lithium Lead breeding blanket (WCLL). To this purpose, detailed 3D models of the DEMO WCLL right inboard and central outboard segments, including detailed BSS and simplified First Wall and structures according to the two concepts, have been set-up. The study has been performed considering the Normal Operation and Central Major Disruption steady state loading s…
A multi-physics integrated approach to breeding blanket modelling and design
2019
Abstract Often, for the design of a component, several kinds of analyses are needed. Even more frequently, the different fields of study, to be taken into account for the design verification, have to be examined minutely until the final results are satisfying. Furthermore, when geometry modifications are required, for instance to fulfill the component functions, the analyses cycle has to be restarted and an iterative process has to be carried out. This procedure may be time-consuming and herald of errors, in particular if it is demanded to the human activity. Therefore, it is more convenient for the scientific community to adopt a numerical tool that can combine various computational codes.…