Search results for "CLL"
showing 10 items of 73 documents
Preliminary design of the top cap of DEMO Water-Cooled Lithium Lead breeding blanket segments
2020
Abstract Within the framework of EUROfusion R&D activity, a research campaign has been carried out at the University of Palermo, in close cooperation with ENEA labs, in order to preliminary design the top cap foreseen for the DEMO Water-Cooled Lithium Lead (WCLL) breeding blanket segments. Due to the high heat and pressure loads acting on such component, its design results particularly demanding and a specific multi-physics approach is needed, covering several aspects from thermal-hydraulics to structural assessments. Preliminary detailed CAD model of the cap integrated into the upper region of the WCLL breeding blanket outboard central segment has been set-up, equipped with proper cooling …
Associations of ofatumumab exposure and treatment outcomes in patients with untreated CLL receiving chemoimmunotherapy
2016
Relationships between patient characteristics, ofatumumab pharmacokinetics, and treatment outcomes were investigated in this phase 2 trial of ofatumumab plus fludarabine and cyclophosphamide (FC) in untreated chronic lymphocytic leukemia. Patients were randomized 1:1 to receive 500 or 1000 mg ofatumumab (Cycle 1; 300 mg) plus FC every 4 weeks for six cycles. Median C(max) and C(trough) values were similar at Cycle 1 regardless of the ultimate clinical outcome. At later doses, these values were higher for patients with complete response (CR) than for other patients. Higher C(max) and C(trough) values at Cycles 3 and 6 were significantly associated with an increased likelihood of CR, whereas …
A study of the potential influence of frame coolant on HCLL-TBM nuclear response
2007
Abstract Within the European Fusion Technology Programme, the Helium-Cooled Lithium Lead (HCLL) breeding blanket concept is one of the two EU lines to be developed for a long term fusion reactor, in particular with the aim of manufacturing a test blanket module (TBM) to be implemented in ITER. The HCLL-TBM is foreseen to be located in an ITER equatorial port, being housed inside a steel-supporting frame, actively cooled by pressurized water. This supporting frame has been designed to house two different TBMs providing two cavities separated by a dividing plate 20 cm thick. As the nuclear response of HCLL-TBM could vary with the supporting frame configuration and composition, a parametric st…
Assessment of the Possible Lay-Out Influence on the HCLL-TBM Nuclear Response
2009
The Department of Nuclear Engineering of the University of Palermo (DIN) was involved, since several years, in the study of the nuclear response of the helium-cooled lithium lead (HCLL) test blanket module (TBM) which will be tested in ITER. In this framework a research campaign was performed, at the DIN, to asses the nuclear response of the TBM in a toroidal lay-out, with the specific aim to investigate the possible lay-out influence on the module nuclear behaviour by comparing the results obtained with those presented in a similar previous work focussed on the most recent design of the poloidal HCLL-TBM. A computational approach based on the Monte Carlo method was followed and a realistic…
Assessment of DEMO WCLL breeding blanket primary heat transfer system isolation valve absorbed doses due to activated water
2020
Abstract Within the framework of the activities foreseen by the EUROfusion action on the cooling water activation assessment for a DEMO reactor equipped with a Water Cooled Lithium Lead Breeding Blanket (WCLL BB), the University of Palermo is involved in the investigation of the absorbed dose induced by the decay of nitrogen radioisotopes produced by water activation, in the main components (e.g. isolation valves) of both First Wall (FW) and Breeder Zone (BZ) cooling circuits. The aim of this work is to assess the spatial distribution of the absorbed dose in the DEMO Upper Pipe Chase (UPC), focusing the attention on the space neighbouring a typical isolation valve of the Primary Heat Transf…
On the influence of the supporting frame on the nuclear response of the Helium-Cooled Lithium Lead Test Blanket Module for ITER
2006
Abstract Within the European Fusion Technology Programme, very intense research activities have been promoted on the Helium-Cooled Lithium Lead (HCLL) breeding blanket concept with the specific aim of manufacturing a Test Blanket Module (TBM) to be irradiated in ITER. HCLL-TBM is foreseen to be located in an ITER equatorial port, being housed inside a proper steel-supporting frame. In particular, since that frame has been designed to provide two cavities separated by a dividing plate and HCLL-TBM is foreseen to fill just one of them, its nuclear response could vary accordingly to the filling status of the other one, unless the dividing plate is thick enough to isolate the components housed …
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
2013
Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 × 10-14), 18q21.33 (BCL2, P = 7.76 × 10-11), 11p15.5 (C11orf21, P = 2.15 × 10 -10), 4q25 (LEF1, P = 4.24 × 10-10), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 × 10-9), 9p21.3 (CDKN2B-AS1, P = 1.27 × 10…
On the optimization of the first wall of the DEMO water-cooled lithium lead outboard breeding blanket equatorial module
2016
Abstract Within the framework of EUROfusion R&D activities a research campaign has been carried out at the University of Palermo in order to investigate the thermo-mechanical performances of the DEMO water-cooled lithium lead (WCLL) breeding blanket first wall (FW). The research campaign has been mainly focused on the optimization of the FW geometric configuration in order to maximize the heat flux it may safely withstand fulfilling all the thermal, hydraulic and mechanical requirements foreseen by safety codes. Attention has been focused on the FW flat concept endowed with square cooling channels and the potential influence of its four main geometrical parameters on its thermo-mechanical p…
Optimization of the breeder zone cooling tubes of the DEMO Water-Cooled Lithium Lead breeding blanket
2016
Abstract The determination of an optimal configuration for the breeder zone (BZ) cooling tubes is one of the most important issues in the DEMO Water-Cooled Lithium Lead (WCLL) breeding blanket R&D activities, since BZ cooling tubes spatial distribution should ensure an efficient heat power removal from the breeder, avoiding hotspots occurrence in the thermal field. Within the framework of R&D activities supported by the HORIZON 2020 EUROfusion Consortium action on the DEMO WCLL breeding blanket design, a campaign of parametric analyses has been launched at the Department of Energy, Information Engineering and Mathematical Models of the University of Palermo (DEIM), in close cooperation with…
Numerical assessment of the thermomechanical behaviour of the DEMO Water-Cooled Lithium Lead inboard blanket equatorial module
2018
Abstract Within the framework of EUROfusion R&D activity, a research campaign has been carried out at the University of Palermo, in close cooperation with ENEA labs, in order to assess the thermo-mechanical performances of the DEMO Water-Cooled Lithium Lead (WCLL) inboard blanket equatorial module, whether properly integrated within its whole inboard segment. In particular, a detailed 3D model of this segment, including all the other modules, the back-supporting structure and the attachment system, has been considered in order to realistically simulate the boundary conditions affecting the equatorial module behaviour. The study has been focused on the investigation of the module thermo-mech…