Search results for "CLO"
showing 10 items of 9986 documents
Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E.coli
2019
Tyrosine nitration is a post-translational protein modification relevant to various pathophysiological processes. Chemical nitration procedures have been used to generate and study nitrated proteins, but these methods regularly lead to modifications at other amino acid residues. A novel strategy employs a genetic code modification that allows incorporation of 3-nitrotyrosine (3-NT) during ribosomal protein synthesis to generate a recombinant protein with defined 3-NT-sites, in the absence of other post-translational modifications. This approach was applied to study the generation and stability of the 3-NT moiety in recombinant proteins produced in E.coli. Nitrated alpha-synuclein (ASYN) was…
Risk of Periodontal Disease: Is there a Correlation with the Type of Antihypertensive Medication?
2011
Introduction: The purpose of this study was to evaluate the effects of long-term oral antihypertensive treatment using centrally acting sympatho-inhibitory drugs (clonidine) and beta-blockers (metoprolol) on capillary microcirculation in the labial and periodontal mucosa.
 Methods: Sixty subjects were recruited for the study: 20 patients affected by hypertension in treatment with centrally-acting sympatho-inhibitory drugs (64.28 ± 11.78 years); 20 patients in treatment with beta-blockers (62.03 ± 9.84 years) and 20 healthy subjects (62.06 ± 6.72 years). We use the videocapillaroscopic technique to evaluate in vivo the microcirculation of the labial mucosa corresponding to the lower lip…
Rationale and evidence on the use of tocilizumab in COVID-19: A systematic review. Authors’ reply
2021
Recycling of almond by-products for intestinal inflammation: improvement of physical-chemical, technological and biological characteristics of a drie…
2020
Background: Almond skins are rich in bioactive compounds that undergo oxidation/degradation phenomena and are poorly soluble in water, reducing in vivo absorption and bioavailability, factors that influence the pharmacological activity of an active product. We developed a dried acetonic almond skins extract/cyclodextrin complex to improve extract solubility, dissolution rate and biological activity. Methods: A lyophilized acetonic almond skin extract was produced. To optimize complex formulation, phase solubility studies and complex characterization (absorption studies, differential scanning calorimetry (DSC), morphology, solubility studies) were performed. To evaluate a possible use in hea…
"Jeg gråter noen tårer hver dag". En fenomenologisk studie av hjemmeboende kreftpasienters beskrivelse av deres livssituasjon i palliativ fase
2020
"I cry a few tears every day". A phenomenological study of at-home cancer patients' description av their life situations under palliativ care
 The aim of this study was to investigate how at-home cancer patients perceived their life situations during the palliative care phase. The study employed a qualitative exploratory research design involving in-depth personal interviews with six women and two men between the ages of 35 and 63. All the interviewees lived at home, experiencing different life situations and suffering from different types of cancer. The interviews were recorded and transcribed verbatim. Data analysis was carried out using the descriptive phenomenological method presen…
The effects of vibration during maximal graded cycling exercise: A pilot study
2012
Whole Body Vibration training is studied and used in different areas, related to sport performance and rehabilitation. However, few studies have investigated the effects of Vibration (Vib) exposure on aerobic performance through the application of this concept to cycling exercise. A specifically designed vibrating cycloergometer, the powerBIKETM, was used to compare the effects of Vib cycling exercise and normal cycling on different physiological parameters during maximal graded exercise test. Twelve recreationally active male adults (25 ± 4.8 yrs; 181.33 ± 5.47 cm; 80.66 ± 11.91 kg) performed two maximal incremental cycling tests with and without Vib in a blockrandomized order. The protoco…
From part to point cloud, the modelling of a 3D part
2019
The present paper focuses on the development of the composite materials in the automotiv industry by making a comparative analysis between a 3D model of the part and a real part made by a composite material, measuring the part using the point cloud. The aim is to obtain a high modeling and a more clear visualization of the composite material part.
Thermodynamic correction of particle concentrations measured by underwing probes on fast-flying aircraft
2016
Particle concentration measurements with underwing probes on aircraft are impacted by air compression upstream of the instrument body as a function of flight velocity. In particular, for fast-flying aircraft the necessity arises to account for compression of the air sample volume. Hence, a correction procedure is needed to invert measured particle number concentrations to ambient conditions that is commonly applicable to different instruments to gain comparable results. In the compression region where the detection of particles occurs (i.e. under factual measurement conditions), pressure and temperature of the air sample are increased compared to ambient (undisturbed) conditions in certain …
Carbon emissions by Ssouth american companies: driving factors for reporting decisions and emissions reduction
2018
In the last decade, companies have started to disclose information on carbon emissions. To our knowledge, this is the first paper to look into this phenomenon in South America, which is a very important geographical area regarding climate change because of the local nature and developing economies. This paper explores the relationships between some corporate variables and two important decisions: (i) whether to report carbon emissions, and (ii) the impact on the evolution of carbon emissions. Logit and linear panel data models are used to determine the driving factors for decisions (i) and (ii). Our results show that regarding the carbon reporting decision, a company&rsquo
Spectroscopic and Structural Investigation of the Confinement of D and L Dimethyl Tartrate in Lecithin Reverse Micelles
2009
The confinement of D and L dimethyl tartrate in lecithin reverse micelles dispersed in cyclohexane has been investigated by FT-IR, polarimetry, electronic and vibrational circular dichroism (ECD and VCD), 1H NMR, and small-angle X-ray scattering (SAXS). Measurements have been performed at room temperature as a function of the solubilizate-to-surfactant molar ratio (R) at fixed lecithin concentration. The analysis of experimental data indicates that the dimethyl tartrate molecules are solubilized within reverse micelles in proximity to the surfactant head groups in the same way for the D and L forms. The encapsulation of dimethyl tatrate within lecithin reverse micelles involves changes in i…