6533b7d9fe1ef96bd126d67c
RESEARCH PRODUCT
Recycling of almond by-products for intestinal inflammation: improvement of physical-chemical, technological and biological characteristics of a dried almond skins extract.
Rita Patrizia AquinoGiovanni PuglisiTeresa MusumeciShara Francesca RapaMaria Rosaria LauroPatrizia PicernoStefania MarzoccoVirgilio Giannonesubject
lcsh:RS1-441Pharmaceutical ScienceAbsorption (skin)Articlelcsh:Pharmacy and materia medica03 medical and health scienceschemistry.chemical_compound0302 clinical medicineDifferential scanning calorimetrycatechinAlmond extractoxidative stressSolubilityDissolutionsolubility studies030304 developmental biologychemistry.chemical_classification0303 health sciencesChromatographyCyclodextrinfood and beveragesCatechinBiological activitycomplex characterizationBioavailabilityAlmond extract; cyclodextrin; catechin; solubility studies; complex characterization; intestinal epithelial cells; inflammation; oxidative stresschemistrycyclodextrininflammation030220 oncology & carcinogenesisintestinal epithelial cellsdescription
Background: Almond skins are rich in bioactive compounds that undergo oxidation/degradation phenomena and are poorly soluble in water, reducing in vivo absorption and bioavailability, factors that influence the pharmacological activity of an active product. We developed a dried acetonic almond skins extract/cyclodextrin complex to improve extract solubility, dissolution rate and biological activity. Methods: A lyophilized acetonic almond skin extract was produced. To optimize complex formulation, phase solubility studies and complex characterization (absorption studies, differential scanning calorimetry (DSC), morphology, solubility studies) were performed. To evaluate a possible use in healthy products, tumor necrosis factor-&alpha
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-09-17 |