0000000000347557

AUTHOR

Shara Francesca Rapa

showing 3 related works from this author

Recycling of almond by-products for intestinal inflammation: improvement of physical-chemical, technological and biological characteristics of a drie…

2020

Background: Almond skins are rich in bioactive compounds that undergo oxidation/degradation phenomena and are poorly soluble in water, reducing in vivo absorption and bioavailability, factors that influence the pharmacological activity of an active product. We developed a dried acetonic almond skins extract/cyclodextrin complex to improve extract solubility, dissolution rate and biological activity. Methods: A lyophilized acetonic almond skin extract was produced. To optimize complex formulation, phase solubility studies and complex characterization (absorption studies, differential scanning calorimetry (DSC), morphology, solubility studies) were performed. To evaluate a possible use in hea…

lcsh:RS1-441Pharmaceutical ScienceAbsorption (skin)Articlelcsh:Pharmacy and materia medica03 medical and health scienceschemistry.chemical_compound0302 clinical medicineDifferential scanning calorimetrycatechinAlmond extractoxidative stressSolubilityDissolutionsolubility studies030304 developmental biologychemistry.chemical_classification0303 health sciencesChromatographyCyclodextrinfood and beveragesCatechinBiological activitycomplex characterizationBioavailabilityAlmond extract; cyclodextrin; catechin; solubility studies; complex characterization; intestinal epithelial cells; inflammation; oxidative stresschemistrycyclodextrininflammation030220 oncology & carcinogenesisintestinal epithelial cells
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Citrus sinensis and Vitis vinifera Protect Cardiomyocytes from Doxorubicin-Induced Oxidative Stress: Evaluation of Onconutraceutical Potential of Veg…

2020

Abstract: The interest towards nutraceuticals able to counteract drug side effects is continuously growing in current chemotherapeutic protocols. In the present study, we demonstrated that smoothies containing mixtures of Citrus sinensis and Vitis vinifera L. cv. Aglianico N, two typical fruits of the Mediterranean diet, possess bioactive polyphenols that protect cardiomyocytes against doxorubicin-induced oxidative stress. The polyphenolic extracts isolated from Citrus sinensis- and Vitis vinifera-based functional smoothies were deeply characterized by Liquid Chromatography-Mass Spectrometry methods. Subsequently, the functional smoothies and relative mixtures were tested to verify their ab…

0301 basic medicineonconutraceuticalPhysiologyClinical BiochemistrycardiotoxicityAnthracyclinemedicine.disease_causeBiochemistryArticle03 medical and health sciences0302 clinical medicineNutraceuticalmedicineoxidative stressDoxorubicinFood scienceVitis viniferaadjuvant therapy; anthracyclines; antioxidants; apoptosis; cardiotoxicity; functional foods; onconutraceutical; oxidative stress; polyphenolsMolecular Biologypolyphenolsfunctional foodsanthracyclinesChemistryFunctional foodlcsh:RM1-950apoptosisApoptosifood and beveragesadjuvant therapyCell Biology030104 developmental biologyantioxidantslcsh:Therapeutics. PharmacologyApoptosisPolyphenol030220 oncology & carcinogenesisOxidative streBreast cancer cellsAntioxidantCitrus × sinensisOxidative stressmedicine.drugAntioxidants
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Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells

2020

Intestinal epithelial cells (IECs) play a pivotal role in maintaining intestinal homeostasis. Different noxious agents, among them also anticancer therapies, can impair intestinal epithelial integrity triggering inflammation and oxidative stress. A frequent complication of chemotherapy is gastrointestinal mucositis, strongly influencing the effectiveness of therapy, increasing healthcare costs, and impairing patients&rsquo

0301 basic medicinegastrointestinal mucositionconutraceuticalPhysiologyClinical BiochemistryInflammationPharmacologymedicine.disease_causeBiochemistryArticleProinflammatory cytokine03 medical and health scienceschemistry.chemical_compound0302 clinical medicineMucositisMedicineoxidative stress5-fluorouracilMolecular BiologyPunica granatum L.polyphenolsoxidative strebiologybusiness.industryNitrotyrosinegastrointestinal mucositislcsh:RM1-950intestinal epithelial cellCell BiologyPunica granatum Lmedicine.diseasebiology.organism_classification5‐fluorouracil; Gastrointestinal mucositis; Inflammation; Intestinal epithelial cells; Onconutraceutical; Oxidative stress; Polyphenols; Punica granatum L5‐fluorouracilpolyphenollcsh:Therapeutics. Pharmacology030104 developmental biologychemistryApoptosisPolyphenolinflammation030220 oncology & carcinogenesisPunicaintestinal epithelial cellsmedicine.symptombusinessOxidative stressAntioxidants
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