Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells

6533b862fe1ef96bd12c6e02

RESEARCH PRODUCT

Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells

Shara Francesca Rapa Alessia Bertamino Emanuela Salviati Giulia Auriemma Giuseppina Autore Stefania Marzocco Cascioferro Stella Pietro Campiglia Andrea Quaroni Giacomo Pepe

subject

0301 basic medicine gastrointestinal mucositi onconutraceutical Physiology Clinical Biochemistry Inflammation Pharmacology medicine.disease_cause Biochemistry Article Proinflammatory cytokine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Mucositis Medicine oxidative stress 5-fluorouracil Molecular Biology Punica granatum L.polyphenols oxidative stre biology business.industry Nitrotyrosine gastrointestinal mucositis lcsh:RM1-950 intestinal epithelial cell Cell Biology Punica granatum L medicine.disease biology.organism_classification 5‐fluorouracil; Gastrointestinal mucositis; Inflammation; Intestinal epithelial cells; Onconutraceutical; Oxidative stress; Polyphenols; Punica granatum L 5‐fluorouracil polyphenol lcsh:Therapeutics. Pharmacology 030104 developmental biology chemistry Apoptosis Polyphenol inflammation 030220 oncology & carcinogenesis Punica intestinal epithelial cells medicine.symptom business Oxidative stress

description

Intestinal epithelial cells (IECs) play a pivotal role in maintaining intestinal homeostasis. Different noxious agents, among them also anticancer therapies, can impair intestinal epithelial integrity triggering inflammation and oxidative stress. A frequent complication of chemotherapy is gastrointestinal mucositis, strongly influencing the effectiveness of therapy, increasing healthcare costs, and impairing patients&rsquo

year	journal	country	edition	language
2020-08-03	Antioxidants

10.3390/antiox9080699 http://europepmc.org/articles/PMC7464015

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