Search results for "CLU"
showing 10 items of 14395 documents
Tourism destination and the role of trust
2012
Tourism destinations increasingly pose new challenges to the organizational and management aspects of tourism. The non-cooperative behavior of some companies, the difficulties of sharing a system of values, the absence or inadequacy of destination managers keep some destinations off the map of growth that is sought for by the stakeholders and shareholders of a given resort. This difficulty seems to lie in the scarce knowledge of the system of relations existing between firms and their degree of cooperation. The application of Social Network Analysis (SNA) and some indicators for network analysis provides a clearer and more analytical map of the links between tourism businesses located withi…
The Need to Approach the Management of the Tourist Destination by the Central and Local Public Authorities in Romania
2017
Abstract In the medium and long term, priorities in the development of tourism aim to develop a complex tourist offer, making the most of the natural and anthropogenic resources existing in connection with the preservation of the environment and the heritage. On the long run, it will contribute to raising the living standards of the population, especially social categories with lower chances of reintegration into the labour market (people made redundant in industry, elderly people etc.). Implementation of the strategy at regional level must be achieved through an active partnership between Romanian public authorities, economic agents and private investors, with the involvement of the federa…
Orientamento e inclusione: uno studio di caso nelle scuole secondarie palermitane di primo grado
2017
This paper presents the main results of the research work that promoted the design and implementation of training and guidance played in the territory of Palermo during the school years 2013/2014 and 2014/2015 in three secondary schools, with operating procedures, capable of promoting inclusive paths, based on the involvement of students, teachers and parents. The assumption from which we started is that the problems of dispersion and social marginalization can be addressed not only through direct guidance interventions with young people at risk, but also involving adults of reference because we are convinced that this will have, even at a distance of time a significant impact on students. …
Extracellular Vesicle microRNAs Contribute to the Osteogenic Inhibition of Mesenchymal Stem Cells in Multiple Myeloma
2020
Osteolytic bone disease is the major complication associated with the progression of multiple myeloma (MM). Recently, extracellular vesicles (EVs) have emerged as mediators of MM-associated bone disease by inhibiting the osteogenic differentiation of human mesenchymal stem cells (hMSCs). Here, we investigated a correlation between the EV-mediated osteogenic inhibition and MM vesicle content, focusing on miRNAs. By the use of a MicroRNA Card, we identified a pool of miRNAs, highly expressed in EVs, from MM cell line (MM1.S EVs), expression of which was confirmed in EVs from bone marrow (BM) plasma of patients affected by smoldering myeloma (SMM) and MM. Notably,we found that miR-129-5p, whic…
PEDAGOGICAL ASSUMPTIONS OF TRANSFORMATIVE DI-GITAL MODEL FOR SOCIAL CHANGE
2019
Creating of digital models which transform learning and its outcomes, as well as the learner’s educational, developmental and educative achievements has become vital to provision of inclusion possibilities in a networked society. Researchers have produced several frameworks of using digital technologies in education, but these are generally do not appropriately incorporate socio-contextual perspectives. To explore this area and create a transformative model of teaching-learning at higher levels of education in Special pedagogy and social work an appropriate pedagogical provisions are needed to transform educational process as a system including: (a) meaningful and transforming objectives, (…
Energy efficient model for biogas production in farm scale
2011
Energy efficient solutions for six farm biogas production was found by calculating mass and energy balance in different scenarios. Raw materials in biogas production were cow manure and grass silage that were produced in these farms. There were calculated mass and energy balances on average for one year biogas prouduction that consisted of grass silage production, raw material transportation and biogas production in the biogas plant. In addition, direct greenhouse gases from biogas production were estimated. The direct mass and energy flows were calculated. It turned out that one input energy unit can produce 5.0 to 5.5 energy units as heat and electricity. Biogas reactor consumed heat from…
Divergent Patterns and Trends in Breast Cancer Incidence, Mortality and Survival Among Older Women in Germany and the United States
2020
Background: Breast cancer treatment has changed tremendously over the last decades. In addition, the use of mammography screening for early detection has increased strongly. To evaluate the impact of these developments, long-term trends in incidence, mortality, stage distribution and survival were investigated for Germany and the United States (US). Methods: Using population-based cancer registry data, long-term incidence and mortality trends (1975&ndash
The small protein SCO2038 modulates tryptophan biosynthesis and morpho-physiological differentiation in Streptomyces coelicolor
2016
In Streptomyces coelicolor small open reading frames were identified in several amino acids biosynthetic gene clusters, like SCO2038 (trpX) in the tryptophan trpCXBA locus. Here, the role of SCO2038, encoding a 63 amino acid protein, was investigated by both phenotypic and molecular analyses. A SCO2038 knockout mutant strain showed a delayed growth on minimal medium (MM), compromised actinorhodin biosynthesis and poor sporulation. The capability of this mutant to grow on MM was restored by tryptophan’s and its precursors’ supplementation. Pulldown and bacterial two hybrid assays revealed SCO2038 interaction with PepA, which is putatively involved in the metabolism of serine, glycine and cys…
Domesticating the future?: Citizen’s income discussion in Estonia
2018
ABSTRACTCitizen’s income is an idea that is currently gaining ground in many parts of the world. The prospect of disappearing jobs and social exclusion that the globalized world faces has given the...
Extracellular Vesicles as Shuttles of Tumor Biomarkers and Anti-Tumor Drugs
2014
Extracellular vesicles (EV) include vesicles released by either normal or tumor cells. EV may exceed the nanometric scale (microvesicles), or to be within the nanoscale, also called exosomes. Thus, it appears that only exosomes and larger vesicles may have the size for potential applications in nanomedicine, in either disease diagnosis or therapy. This is of particular interest for research in cancer, also because the vast majority of existing data on EV are coming from pre-clinical and clinical oncology. We know that the microenvironmental features of cancer may favor cell-to-cell paracrine communication through EV, but EV have been purified, characterized, and quantified from plasma of tu…