Search results for "CMA"
showing 10 items of 188 documents
The Bernstein Basis and its applications in solving geometric constraint systems
2012
International audience; This article reviews the properties of Tensorial Bernstein Basis (TBB) and its usage, with interval analysis, for solving systems of nonlinear, univariate or multivariate equations resulting from geometric constraints. TBB are routinely used in computerized geometry for geometric modelling in CAD-CAM, or in computer graphics. They provide sharp enclosures of polynomials and their derivatives. They are used to reduce domains while preserving roots of polynomial systems, to prove that domains do not contain roots, and to make existence and uniqueness tests. They are compatible with standard preconditioning methods and fit linear program- ming techniques. However, curre…
Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid
2015
Abstract The objective of this paper is to apply a previously developed semi-physiologic pharmacokinetic model implemented in NONMEM to simulate bioequivalence trials (BE) of acetyl salicylic acid (ASA) in order to validate the model performance against ASA human experimental data. ASA is a drug with first-pass hepatic and intestinal metabolism following Michaelis–Menten kinetics that leads to the formation of two main metabolites in two generations (first and second generation metabolites). The first aim was to adapt the semi-physiological model for ASA in NOMMEN using ASA pharmacokinetic parameters from literature, showing its sequential metabolism. The second aim was to validate this mod…
Computer simulations for bioequivalence trials: Selection of analyte in BCS class II and IV drugs with first-pass metabolism, two metabolic pathways …
2018
A semi-physiological two compartment pharmacokinetic model with two active metabolites (primary (PM) and secondary metabolites (SM)) with saturable and non-saturable pre-systemic efflux transporter, intestinal and hepatic metabolism has been developed. The aim of this work is to explore in several scenarios which analyte (parent drug or any of the metabolites) is the most sensitive to changes in drug product performance (i.e. differences in in vivo dissolution) and to make recommendations based on the simulations outcome. A total of 128 scenarios (2 Biopharmaceutics Classification System (BCS) drug types, 2 levels of KM Pgp, in 4 metabolic scenarios at 2 dose levels in 4 quality levels of t…
Data for: Analytical induced force solution in conducting cylindrical bodies and rings due to a rotating finite permanent magnet
2019
Implementation of analytical current density solution in numerical calculations using Wolfram Mathematica software. THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOVE
On a new proof of Moser's twist mapping theorem
1976
Based on a new idea of the author, a new proof of J. Moser's twist mapping theorem is presented.
Computation of a few smallest eigenvalues of elliptic operators using fast elliptic solvers
2001
The computation of a few smallest eigenvalues of generalized algebraic eigenvalue problems is studied. The considered problems are obtained by discretizing self-adjoint second-order elliptic partial differential eigenvalue problems in two- or three-dimensional domains. The standard Lanczos algorithm with the complete orthogonalization is used to compute some eigenvalues of the inverted eigenvalue problem. Under suitable assumptions, the number of Lanczos iterations is shown to be independent of the problem size. The arising linear problems are solved using some standard fast elliptic solver. Numerical experiments demonstrate that the inverted problem is much easier to solve with the Lanczos…
A biproportional filter to compare technical and allocation coefficient variations
1997
International audience; In input-output analysis there are two alternate possibilities between Leontief's mechanism (fixed technical coefficients) and Ghosh's mechanism (fixed allocation coefficients). Testing the long term consistency of these mechanisms entails comparing input-output matrices over time. This paper challenges the value of proportional filters (separate comparison of column and row coefficients) and introduces the biproportional filter which allows simultaneous comparison of column and rows. An application is proposed using French input-output tables for 1980 and 1993. The stability of column coefficients cannot be taken for granted and generally, for any sector, both rows …
Clinical and Neurophysiological Follow-Up of Chronic Inflammatory Demyelinating Polyneuropathy Patients Treated with Subcutaneous Immunoglobulins: A …
2022
Background: chronic idiopathic demyelinating polyneuropathy (CIDP) is an acquired, immune-mediated neuropathy characterized by weakness, sensory symptoms and significant reduction or loss of deep tendon reflexes evolving over 2 months at least, associated with electrophysiological evidence of peripheral nerve demyelination. Recently, subcutaneous immunoglobulins (SCIg) have been introduced in clinical practice as a maintenance therapy for CIDP; nevertheless, electrophysiological and efficacy data are limited. Methods: to evaluate SCIg treatment efficacy, we retrospectively reviewed data from 15 CIDP patients referring to our clinic, receiving SCIg treatment and who performed electrophysiolo…
Abstract CT109: A phase I/Ib study evaluating GDC-0077 plus fulvestrant in patients with PIK3CA-mutant, hormone receptor-positive/HER2-negative breas…
2020
Abstract Background: PIK3CA encodes the PI3K p110α subunit, and dysregulating mutations are widely seen in breast cancer (BC) and other solid tumors. GDC-0077 (G) is a potent p110α-selective inhibitor that degrades mutant p110α and demonstrates antitumor activity in PIK3CA-mutant BC xenograft models, either as a single agent, or combined with anti-estrogen therapy. From an ongoing, open-label, phase I/Ib dose-escalation study of G alone and combined with endocrine + targeted therapies (NCT03006172), we present data of G + fulvestrant (F) in postmenopausal patients (pts) with PIK3CA-mutant, hormone receptor-positive/HER2-negative BC, including a food-effect assessment on the pharmacokinetics…
A True Extension of the Markov Inequality to Negative Random Variables
2020
The Markov inequality is a classical nice result in statistics that serves to demonstrate other important results as the Chebyshev inequality and the weak law of large numbers, and that has useful applications in the real world, when the random variable is unspecified, to know an upper bound for the probability that an variable differs from its expectation. However, the Markov inequality has one main flaw: its validity is limited to nonnegative random variables. In the very short note, we propose an extension of the Markov inequality to any non specified random variable. This result is completely new.