Search results for "CMA"

showing 10 items of 188 documents

Toward Biopredictive Dissolution for Enteric Coated Dosage Forms

2016

The aim of this work was to develop a phosphate buffer based dissolution method for enteric-coated formulations with improved biopredictivity for fasted conditions. Two commercially available enteric-coated aspirin products were used as model formulations (Aspirin Protect 300 mg, and Walgreens Aspirin 325 mg). The disintegration performance of these products in a physiological 8 mM pH 6.5 bicarbonate buffer (representing the conditions in the proximal small intestine) was used as a standard to optimize the employed phosphate buffer molarity. To account for the fact that a pH and buffer molarity gradient exists along the small intestine, the introduction of such a gradient was proposed for p…

Chemistry PharmaceuticalCmaxBiological AvailabilityPharmaceutical Science02 engineering and technologyBuffers030226 pharmacology & pharmacyDosage form03 medical and health sciencesFirst pass effect0302 clinical medicineIVIVCCoated Materials BiocompatibleIntestine SmallDrug DiscoverymedicineHumansSolubilityDissolutionDosage FormsChromatographyAspirinGastric emptyingChemistryHydrogen-Ion Concentration021001 nanoscience & nanotechnologyEnteric coatingBicarbonatesDrug LiberationKineticsGastric EmptyingSolubilityArea Under CurveMolecular Medicine0210 nano-technologymedicine.drugMolecular Pharmaceutics
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Computing with Rational Symmetric Functions and Applications to Invariant Theory and PI-algebras

2012

The research of the first named author was partially supported by INdAM. The research of the second, third, and fourth named authors was partially supported by Grant for Bilateral Scientific Cooperation between Bulgaria and Ukraine. The research of the fifth named author was partially supported by NSF Grant DMS-1016086.

Classical Invariant Theory05A15 05E05 05E10 13A50 15A72 16R10 16R30 20G05MacMahon Partition AnalysisHilbert SeriesRational symmetric functions classical invariant theory algebras with polynomial identity cocharacter sequenceMathematics - Rings and AlgebrasCommutative Algebra (math.AC)Mathematics - Commutative AlgebraRational Symmetric FunctionsAlgebras with Polynomial IdentitySettore MAT/02 - AlgebraRings and Algebras (math.RA)Noncommutative Invariant TheoryFOS: MathematicsCocharacter SequenceMathematics - CombinatoricsCombinatorics (math.CO)
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Calcification is not the Achilles' heel of cold-water corals in an acidifying ocean

2015

Ocean acidification is thought to be a major threat to coral reefs: laboratory evidence and CO2 seep research has shown adverse effects on many coral species, although a few are resilient. There are concerns that cold-water corals are even more vulnerable as they live in areas where aragonite saturation (?ara) is lower than in the tropics and is falling rapidly due to CO2 emissions. Here, we provide laboratory evidence that net (gross calcification minus dissolution) and gross calcification rates of three common cold-water corals, Caryophyllia smithii, Dendrophyllia cornigera, and Desmophyllum dianthus, are not affected by pCO2 levels expected for 2100 (pCO2 1058 ?atm, ?ara 1.29), and nor a…

CnidariaSettore BIO/07 - EcologiaCaryophyllia smithiiCoralcold-water coralsocean acidificationengineering.materialCaryophyllia smithiiDendrophyllia cornigeraCold-water coralcalcification and dissolutionCalcification PhysiologicAnthozoaTheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITYComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATIONMediterranean SeaAnimalsEnvironmental ChemistrySeawaterGlobal ChangeReefDesmophyllum dianthuGeneral Environmental ScienceGlobal and Planetary ChangegeographyDesmophyllum dianthusgeography.geographical_feature_categorybiologyEcology2300EcologyAragoniteOcean acidificationfungiCalcification and dissolutionOcean acidificationCoral reefbiochemical phenomena metabolism and nutritionCarbon DioxideHydrogen-Ion Concentrationbiology.organism_classificationAnthozoaOceanographyengineeringCold-water coralsgeographic locationsMathematicsofComputing_DISCRETEMATHEMATICS
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The Linear Ordering Polytope

2010

So far we developed a general integer programming approach for solving the LOP. It was based on the canonical IP formulation with equations and 3-dicycle inequalities which was then strengthened by generating mod-k-inequalities as cutting planes. In this chapter we will add further ingredients by looking for problem- specific inequalities. To this end we will study the convex hull of feasible solutions of the LOP: the so-called linear ordering polytope.

CombinatoricsConvex hullLinear programmingBirkhoff polytopeComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATIONConvex polytopeCross-polytopeMathematicsofComputing_NUMERICALANALYSISUniform k 21 polytopeEhrhart polynomialVertex enumeration problemMathematics
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RationalizeRoots: Software package for the rationalization of square roots

2020

The computation of Feynman integrals often involves square roots. One way to obtain a solution in terms of multiple polylogarithms is to rationalize these square roots by a suitable variable change. We present a program that can be used to find such transformations. After an introduction to the theoretical background, we explain in detail how to use the program in practice.

Computational PhysicsComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATIONOtherInterdisciplinary sciences
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MultivariateApart: Generalized partial fractions

2021

We present a package to perform partial fraction decompositions of multivariate rational functions. The algorithm allows to systematically avoid spurious denominator factors and is capable of producing unique results also when being applied to terms of a sum separately. The package is designed to work in Mathematica, but also provides interfaces to the Form and Singular computer algebra systems.

Computer Science - Symbolic ComputationHigh Energy Physics - TheoryFOS: Computer and information sciencesPolynomialComputer scienceFOS: Physical sciencesGeneral Physics and AstronomyRational functionSymbolic Computation (cs.SC)Partial fraction decomposition01 natural sciencesGröbner basisHigh Energy Physics - Phenomenology (hep-ph)ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION0103 physical sciences010306 general physicsSpurious relationshipcomputer.programming_language010308 nuclear & particles physicsFunction (mathematics)Symbolic computationAlgebraHigh Energy Physics - PhenomenologyHigh Energy Physics - Theory (hep-th)Hardware and ArchitectureComputer Science::Mathematical SoftwareWolfram LanguagecomputerComputer Physics Communications
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Explicit solutions of Riccati equations appearing in differential games

1990

Abstract In this paper an explicit closed form solution of Riccati differential matrix equations appearing in games theory is given.

Computer Science::Computer Science and Game TheoryApplied MathematicsMathematical analysisMathematicsofComputing_NUMERICALANALYSISLinear-quadratic regulatorAlgebraic Riccati equationMatrix (mathematics)ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATIONRiccati equationApplied mathematicsClosed-form expressionGame theoryDifferential (mathematics)MathematicsApplied Mathematics Letters
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Some subgroup embeddings in finite groups: A mini review

2015

[EN] In this survey paper several subgroup embedding properties related to some types of permutability are introduced and studied. ª 2014 Production and hosting by Elsevier B.V. on behalf of Cairo University

Computer scienceMini Reviewmacromolecular substancesS-permutabilityMini reviewMathematics::Group TheoryComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATIONPermutabilityPrimitive subgroupAlgebra over a fieldFinite grouplcsh:Science (General)GeneralFinite grouplcsh:R5-920MultidisciplinaryMathematics::Combinatoricsmusculoskeletal neural and ocular physiologyAlgebranervous systemEmbeddingQuasipermutable subgrouplcsh:Medicine (General)MATEMATICA APLICADAAlgorithmSemipermutabilityMathematicsofComputing_DISCRETEMATHEMATICSlcsh:Q1-390Journal of Advanced Research
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MultivariateApart: Generalized partial fractions

2021

We present a package to perform partial fraction decompositions of multivariate rational functions. The algorithm allows to systematically avoid spurious denominator factors and is capable of producing unique results also when being applied to terms of a sum separately. The package is designed to work in Mathematica, but also provides interfaces to the Form and Singular computer algebra systems. THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOVE

ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATIONComputer Science::Mathematical SoftwareInterdisciplinary sciencesOther
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Computer code from Sex roles and the evolution of parental care specialization.

2019

Computer code for the mathematical model in Mathematica

ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATIONMathematicsofComputing_NUMERICALANALYSISMathematicsofComputing_GENERALComputer Science::Mathematical SoftwareComputer Science::Symbolic Computation16. Peace & justice
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