Search results for "CN"
showing 10 items of 9699 documents
How Geography and Climate Shaped the Genomic Diversity of Italian Local Cattle and Sheep Breeds
2022
International audience; Understanding the relationships among geography, climate, and genetics is increasingly important for animal farming and breeding. In this study, we examine these inter-relationships in the context of local cattle and sheep breeds distributed along the Italian territory. To this aim, we used redundancy analysis on genomic data from previous projects combined with geographical coordinates and corresponding climatic data. The effect of geographic factors (latitude and longitude) was more important in sheep (26.4%) than that in cattle (13.8%). Once geography had been partialled out of analysis, 10.1% of cattle genomic diversity and 13.3% of that of sheep could be ascribe…
A sensitivity analysis on environmental sustainability in sheet metal forming
2011
A sensitivity analysis on artificial neural networks fracture predictions in sheet metal forming operations
2008
Polymeric nanoparticles for siRNA delivery: Production and applications
2017
Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical formulations for the treatment of deadly diseases, such as cancer, pulmonary, ocular and neurodegenerative diseases. However, several considerations regarding the stability, formulation, and efficacy have to be faced up until these systems could be considered to be a marketable pharmaceutical products for to extend siRNA application to clinical practice. This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for o…
Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.
2021
Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…
Inulin Derivatives Obtained Via Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery
2015
A new class of therapeutic agents with a high potential for the treatment of different socially relevant human diseases is represented by Nucleic Acid Based Drugs (NABD), including small interfering RNAs (siRNA), decoy oligodeoxynucleotides (decoy ODN) and antisense oligonucleotides (ASOs). Although NABD can be engineered to be specifically directed against virtually any target, their susceptibility to nuclease degradation and the difficulty of delivery into target tissues severely limit their use in clinical practice and require the development of an appropriate nanostructured delivery system. For delivery of NABD, Inulin (Inu), a natural, water soluble and biocompatible polysaccharide, wa…
Effects of ectopic expression of NGAL on doxorubicin sensitivity.
2012
Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are important in the transport of iron. NGAL also has important biological functions involved in immunity and inflammation as well as responses to kidney damage. NGAL expression has also been associated with certain neoplasia and is important in the metastasis of breast cancer. Many advanced cancer patients have elevated levels of NGAL in their urine and it has been proposed that NGAL may be a prognostic indicator for certain cancers (e.g. breast, brain, and others). NGAL exp…
"Postfit yields Y(4S)" of "Search for $B^{+}\to K^{+}\nu\bar{\nu}$ decays using an inclusive tagging method at Belle II"
2022
Yields in on-resonance data and as predicted by the simultaneous fit to the on- and off-resonance data, corresponding to an integrated luminosity of 63 and 9 fb$^{−1}$, respectively. The predicted yields are shown individually for charged and neutral B-meson decays and the five continuum background categories. The leftmost three bins belong to the first control region (CR1) with BDT$_{2} \in [0.93; 0.95]$ and the other nine bins correspond to the signal region (SR), three for each range of BDT$_{2} \in [0.95; 0.97; 0.99; 1.0]$. Each set of three bins is defined by $p_{T}(K^{+}) \in [0.5; 2.0; 2.4; 3.5] \rm{GeV}/c^{2}$.
"Postfit yields off-resonance" of "Search for $B^{+}\to K^{+}\nu\bar{\nu}$ decays using an inclusive tagging method at Belle II"
2022
Yields in off-resonance data and as predicted by the simultaneous fit to the on- and off-resonance data, corresponding to an integrated luminosity of 63 and 9 fb$^{−1}$, respectively. The predicted yields are shown individually for the five continuum background categories. The leftmost three bins belong to the third control region (CR3) with BDT$_{2} \in [0.93; 0.95]$ and the other nine bins correspond to the second control region (CR2), three for each range of BDT$_{2} \in [0.95; 0.97; 0.99; 1.0]$. Each set of three bins is defined by $p_{T}(K^{+}) \in [0.5; 2.0; 2.4; 3.5] \rm{GeV}/c^{2}$.
UPTAKE OF SILICA COVERED QUANTUM DOTS ON LIVING CELLS: LONG TERM VITALITY AND MORPHOLOGY STUDY ON HYALURONIC ACID BIOMATERIALS
2015
In this work we prepared colloidal CdSe-CdS core-shell nanocrystal emitting @625 nm and, by a micro-emulsion procedure of water in oil inverse micelle, we encapsulated a single dot inside each silica sphere. In this way the nanoparticles became biocompatible, are simply to prepare and could be used also in a water based environment. Moreover, the silica shield is transparent to the wavelengths of interest.