Search results for "CNS"
showing 10 items of 74 documents
Sindrome di di Crigler-Najjar tipo 2: due nuove mutazioni missense nel gene UGT1A1.
2009
La sindrome di Crigler-Najjar (CNS) è una malattia molto rara (prevalenza 1/1.000.000 nati) a trasmissione autosomica recessiva, caratterizzata da un incremento cronico e grave di bilirubina sierica indiretta (non coniugata), dovuta alla parziale (tipo 2) o completa (tipo 1) assenza funzionale dell’enzima epatico glucoronosil transferasi UGT1. La malattia si manifesta in età neonatale con un ittero precoce e intenso, dovuto alla presenza di bilirubina non coniugata e l'esame fisico è nella norma; in epoca di sviluppo gli effetti clinici della CNS tipo 1 sono letali in quanto l’eccesso di bilirubina porta inevitabilmente ad una encefalopatia essendo tale pigmento fortemente liposolubile. Le …
Malformations of central nervous system: General issues
2013
Malformations of the central nervous system (CNS) encompass a heterogeneous group of congenital anomalies that may be isolated or appear as part of a genetic syndrome. Advances in identifying the genetic etiology underlying many CNS malformation and syndromes have led to the current genetic-based classifications that allows us to better estimate prognosis and potential complications. Herein, we discuss the main genetic, clinical and radiological features and their implications for diagnostic testing and disease management
Differentiating Multiple Sclerosis From AQP4-Neuromyelitis Optica Spectrum Disorder and MOG-Antibody Disease With Imaging.
2023
Background and ObjectivesRelapsing-remitting multiple sclerosis (RRMS), aquaporin-4 antibody–positive neuromyelitis optica spectrum disorder (AQP4-NMOSD), and myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) may have overlapping clinical features. There is an unmet need for imaging markers that differentiate between them when serologic testing is unavailable or ambiguous. We assessed whether imaging characteristics typical of MS discriminate RRMS from AQP4-NMOSD and MOGAD, alone and in combination.MethodsAdult, nonacute patients with RRMS, APQ4-NMOSD, and MOGAD and healthy controls were prospectively recruited at the National Hospital for Neurology and Neurosurgery (L…
Triiodothyronine accelerates the synthesis of synapsin I in developing neurons from fetal rat brain cultured in a synthetic medium.
1990
The effect of Triiodothyronine (T3) on Synapsin I appearance in rat cortical neurons has been investigated in vitro. Neuronal cultures from 16-day-old fetal rat brain grown in the absence of T3, express immunohystochemically detectable Synapsin I at the 14th day in vitro. The addition of the hormone to the culture medium determines an early (at the 7th day in vitro) appearance of fluorescent dots specific for Synapsin I. © 1990 Plenum Publishing Corporation.
Poliprenolu efekti uz Wistar līnijas žurku telpisko atmiņu stresa modelī
2016
Poliprenoli (PP) ir vitāli svarīgi komponenti dzīvo organismu šūnās, tiem piemīt hepatoprotektīva, pretvīrusa, imūnmodulējoša un holesterīna pazeminoša iedarbība (Vais et al., 2012; Safatov et al., 2000; Pronin et al., 2013;). Ir maz pētīts par to ietekmi uz CNS funkcijām, atsevišķi dati liecina ka PP uzlabo kognitīvās funkcijas Alcheimera slimības (AD) žurku modelī (Fedotova et al., 2010; Wang et al., 2014). PP piemīt arī antioksidatīvā iedarbība (Bizzarri et al., 2003) , tāpēc tas liek domāt, ka PP var pasargāt no stresa negatīvās ietekmes uz kognitīvām funkcijām. Darba mērķis bija izvērtēt PP iedarbību per se un akūta stresa ietekmē uz izmēģīnājuma dzīvniekiem (Wistar līnijas žurkām) atm…
Zentral dämpfende Wirkstoffe, 7. Mitt. Kernsubstituierte (Diallylamino)-1,3,5-triazine
1988
Aus der Umsetzung von 2,4-Dichlor-6-(diallylamino)-1,3,5-triazin (1) mit langkettigen primaren (2a-b) und cyclischen sekundaren (2c-f) Aminen gehen die kernsubstituierten Chlor-diallylamino-1,3,5-triazine (3a-f) hervor. Ein fur Strukturtyp 3 charakteristischer ms Fragmentierungsweg beinhaltet die Umbildung der Diallylaminogruppe zum Aziridinring. Unter den neu entwickelten Verbindungen findet sich zentral dampfende Wirksamkeit besonders in 3a ausgepragt. Daruber hinaus weist Strukturtyp 3 Antiprotozoen-, anthelminthische und insektenwachstumsregulatorische Wirkung auf. CNS Depressants, VII: (Diallylamino)-1,3,5-triazines Substituted at the Triazine Nucleus The reaction of 2,4-dichloro-6-(di…
Effect of extracellular vesicles from CSF of multiple sclerosis patients and healthy controls on astrocytes in culture
2017
INTRODUCTION Secretion of extracellular vesicles (EVs) and EV-mediated exchange of molecules among brain cells, under physiological conditions, has been described years ago. At the same time, ability of EVs to transfer proteins and nucleic acids to the surrounding cells, thus modifying their phenotypes, has been clearly demonstrated for tumor cells of different origins, including brain cancers. More recently, involvement of EVs in pathological processes affecting the Central Nervous System (CNS), and their capacity of transferring damaging cargoes have been also suggested. To explore these functions, we exposed primary cultures of astrocytes to EVs isolated from cerebral spinal fluid (CSF) …
Komercnoslēpuma aizsardzība un tā ietekme uz personas tiesībām iegūt informāciju
2018
Eiropas Savienības dalībvalstu atšķirīgais normatīvais regulējums komercnoslēpuma aizsardzībā un 2016. gadā pieņemtā Komercnoslēpuma aizsardzības dirketīva ir raisījusi plašas diskusijas šo tiesību ietekmē uz sabiedrības tiesībāms uz informāciju. Tādēļ darbā tiek izpētīts un izanalizēts tiesību uz informāciju nozīmīgumus demokrātiskā sabiedrībā, nonākot līdz šo tiesību būtības un piemērošanas jomu noskaidrošanai. Tāpat tiek vērtēta un analizēta komercnoslēpuma aizsardzības būtība un tvērums. Tiek izvērtēti un salīdzināti gan ECT, gan EST, Eiropas valstu un ASV normatīvais regulējumus un tiesu spriedumi, kā arī tiek apskatīti dažādi tiesībzinātnieku viedokļi, lai noskaidrotu galvenos problēm…
Association of serum neurofilament light chain levels and neuropsychiatric manifestations in systemic lupus erythematosus
2021
Background: The aim was to evaluate the diagnostic potential of serum neurofilament light chain (sNfL) measurements in patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Methods: sNfL levels were determined by single molecule array assay in a retrospective cross-sectional cohort of 144 patients with systemic lupus erythematosus (SLE). After log-transformation of sNfL levels, mean sNfL levels were compared between NPSLE patients and SLE patients without neuropsychiatric disease using Student’s t test. Furthermore, the association of different neuropsychiatric manifestations with sNfL levels was assessed using a one-way analysis of variance (ANOVA) with post hoc analysis. As…
Recommendations for the clinical use of somatosensory-evoked potentials
2008
The International Federation of Clinical Neurophysiology (IFCN) is in the process of updating its Recommendations for clinical practice published in 1999. These new recommendations dedicated to somatosensory-evoked potentials (SEPs) update the methodological aspects and general clinical applications of standard SEPs, and introduce new sections dedicated to the anatomical-functional organization of the somatosensory system and to special clinical applications, such as intraoperative monitoring, recordings in the intensive care unit, pain-related evoked potentials, and trigeminal and pudendal SEPs. Standard SEPs have gained an established role in the health system, and the special clinical ap…