Search results for "COD"

Modulating Long Term Memory at Late-Encoding Phase: An rTMS Study

2021

Despite a huge effort of the scientific community, the functioning of Long-Term Memory (LTM) processes is still debated and far from being elucidated. Functional and neurophysiological data point to an involvement of Dorsolateral Prefrontal Cortex (DLPFC) in both encoding and retrieval phases. However, the recently proposed Explicit/Implicit Memory Encoding and Retrieval (EIMER) model proposes that LTM at the encoding phase consists of anatomically and chronologically different sub-phases. On this basis, we aimed to investigate the role of right DLPFC during a late-encoding phase by means of low-frequency rTMS. Thirty right-handed healthy subjects were divided into three experimental groups…

Capitalismo sin límites

2008

Plasmatic extracellular vesicle microRNAs in malignant pleural mesothelioma and asbestos-exposed subjects suggest a 2-miRNA signature as potential bi…

2017

Background Malignant Pleural Mesothelioma (MPM) is an aggressive cancer mainly caused by asbestos exposure and refractory to current therapies. Specific diagnostic markers for early MPM diagnosis are needed. Changes in miRNA expression have been implicated in several diseases and cancers, including MPM. We examined if a specific miRNA signature in plasmatic extracellular vesicles (EV) may help to discriminate between malignant pleural mesothelioma patients (MPM) and subjects with Past Asbestos Exposure (PAE). Methodology/Principal findings We investigated 23 MPM patients and 19 cancer-free subjects with past asbestos exposure (PAE). We screened 754 miRNAs in plasmatic EVs by OpenArray and f…

Posttranscriptional RNA Modifications: Playing Metabolic Games in a Cell’s Chemical Legoland

2014

Nature combines existing biochemical building blocks, at times with subtlety of purpose. RNA modifications are a prime example of this, where standard RNA nucleosides are decorated with chemical groups and building blocks that we recall from our basic biochemistry lectures. The result: a wealth of chemical diversity whose full biological relevance has remained elusive despite being public knowledge for some time. Here, we will highlight a number of modifications that, because of their chemical intricacy, rely on seemingly unrelated pathways to provide co-factors for their synthesis. Besides their immediate role in affecting RNA function, modifications may act as sensors and transducers of i…

Effects of environmental and spatial variables on lotic ostracod metacommunity structure in the Iberian Peninsula

2015

The heterogeneous distribution of aquatic species in lotic environments has been studied little in terms of metacommunity theory. Previous empirical tests have found significant spatial and environmental effects in pond and lake communities, but this has not yet been clearly established for stream networks. We conducted a multi-season survey of mountain streams in the Iberian Peninsula. We recorded GIS and in situ environmental data and collected biological samples to determine ostracods and macroinvertebrates and identified 41 ostracod species, the most common belonging to genera Herpetocypris , Sarscypridopsis , and Ilyocypris . A generalized linear model analysis showed that thermal rang…

Molecular analysis of the fungal community associated with phyllosphere and carposphere of fruit crops

Analysis of metal spinning processes by the ADINA code

1989

Abstract The ADINA code, version 84, has been employed for the analysis of sheet spinning processes. The main process parameters have been evaluated in different working conditions; namely for various geometries and constitutive laws of the material.

Statistical atmospheric parameter retrieval largely benefits from spatial-spectral image compression

2021

The infrared atmospheric sounding interferometer (IASI) is flying on board of the Metop satellite series, which is part of the EUMETSAT Polar System. Products obtained from IASI data represent a significant improvement in the accuracy and quality of the measurements used for meteorological models. Notably, the IASI collects rich spectral information to derive temperature and moisture profiles, among other relevant trace gases, essential for atmospheric forecasts and for the understanding of weather. Here, we investigate the impact of near-lossless and lossy compression on IASI L1C data when statistical retrieval algorithms are later applied. We search for those compression ratios that yield…

Cloning and functional analysis of cDNA encoding the hamster Bcl-2 protein.

2000

We have cloned cDNA encoding hamster Bcl-2 protein from total RNA of CHO-9 cells by RT-PCR using oligonucleotide primers sharing homology with the sequence of mouse and rat bcl-2. The fragments spanning the total coding region were cloned into pCR4-TOPO and sequenced for verification. The hamster bcl-2 cDNA has a size of 711 nucleotides and encodes a polypeptide of 236 amino acids. Hamster Bcl-2 shares 95.8 and 88.6% similarity with mouse and human Bcl-2, respectively. Northern blot analysis revealed a single 7.5 kb bcl-2 transcript in hamster (CHO-9), mouse (BK4), and rat (H5) cells and a 8.5 kb bcl-2 mRNA in human (HeLa MR) cells. The bcl-2 cDNA (771 bp) was recloned into pcDNA3 and the r…

MicroRNAs, the immune system and rheumatic disease.

2008

MicroRNAs (miRNAs) have been implicated in the pathogenesis of rheumatic disease and are, therefore, a potential target for drug development. This Review describes the well-established roles of miRNAs in hematopoiesis and the immune response, the molecular action of miRNAs in the simultaneous post-transcriptional regulation of multiple targets, and the evidence for roles of specific miRNAs in rheumatic disease. MicroRNAs (miRNAs) are short noncoding RNA molecules that modulate the expression of multiple target genes at the post-transcriptional level and are implicated in a wide array of cellular and developmental processes. In hematopoietic cells, miRNA levels are dynamically regulated duri…