Search results for "COD"

Constitutive hsp70 is essential to mitosis during early cleavage of Paracentrotus lividus embryos: The blockage of constitutive hsp70 impairs mitosis

1999

Localization of constitutive hsp70 in eggs and early embryos of sea urchin Paracentrotus lividus is shown by means of in situ immunostaining. An accumulation of this protein is shown in the mitotic structures (asters, spindles and centrosomes). Microinjection of anti-hsp70 antibodies into eggs causes impairment of formation of mitotic structures and of cell division. This impairment goes from a complete mitotic block, to irregular mitotic apparatus formation with irregular cleavage, depending upon the antibody concentration. The localization of hsp70 after antibody microinjection is also described. Blockage of mitotic apparatus formation by nocodazole also blocks the concentration of hsp70 …

Nucleosome-specific, Time-dependent Changes in Histone Modifications during Activation of the Early Growth Response 1 (Egr1) Gene

2014

Histone post-translational modifications and nucleosome remodeling are coordinate events involved in eukaryotic transcriptional regulation. There are relatively few data on the time course with which these events occur in individual nucleosomes. As a contribution to fill this gap, we first describe the nature and time course of structural changes in the nucleosomes -2, -1, and +1 of the murine Egr1 gene upon induction. To initiate the transient activation of the gene, we used the stimulation of MLP29 cells with phorbol esters and the in vivo activation after partial hepatectomy. In both models, nucleosomes -1 and +1 are partially evicted, whereas nucleosomes +1 and -2 slide downstream durin…

Biologically inspired information processing and synchronization in ensembles of non-identical threshold-potential nanostructures.

2013

Nanotechnology produces basic structures that show a significant variability in their individual physical properties. This experimental fact may constitute a serious limitation for most applications requiring nominally identical building blocks. On the other hand, biological diversity is found in most natural systems. We show that reliable information processing can be achieved with heterogeneous groups of non-identical nanostructures by using some conceptual schemes characteristic of biological networks (diversity, frequency-based signal processing, rate and rank order coding, and synchronization). To this end, we simulate the integrated response of an ensemble of single-electron transisto…

Development of helium coolant DEMO first wall model for SYCOMORE system code based on HCLL concept

2018

Abstract The conceptual design of the demonstration fusion power reactor, known as DEMO, is ongoing and several reactor configurations have to be investigated by exploring different design parameters. For these reasons, within the European framework, systems codes like SYCOMORE (SYstem COde for MOdelling tokamak REactor) have been developed. SYCOMORE includes several specific modules, one of which is aimed to define a suitable design of the helium breeding blanket. The research activity has been devoted to improve the method to define automatically the First Wall design starting from thermal-hydraulic and thermo-mechanical considerations, using analytical design formulae and, also, taking i…

A Lightweight Network Discovery Algorithm for Resource-constrained IoT Devices

2019

Although quite simple, existing protocols for the IoT suffer from the inflexibility of centralized infrastructures and require several configuration stages. The implementation of these protocols is often prohibitive on resource-constrained devices. In this work, we propose a distributed lightweight implementation of network discovery for simple IoT devices. Our approach is based on the exchange of symbolic executable code among nodes. Based on this abstraction, we propose an algorithm that makes even IoT resource-constrained nodes able to construct the network topology graph incrementally and without any a priori information about device positioning and presence. The minimal set of executab…

The Tortricidae described by J. C. Fabricius (Lepidoptera)

2011

The identity and nomenclature of the 88 species of Tortricidae (Lepidoptera) described by J. C. Fabricius are reviewed. Type material deposited in the Natural History Museum Denmark is illustrated. Lectotypes for Tinea compositella (Fabricius, 1775), Pyralis rivellana (Fabricius, 1775) and P. strigana (Fabricius, 1775) are designated. Two new synonymies are proposed: Pyralis marmorana (Fabricius, 1798), syn. n., of Ancylis achatana (Denis and Schiffermuller, 1775), and P. rusticana (Fabricius, 1794), syn. n., of Epinotia solandriana (Linnaeus, 1758). In an appendix, the identity and nomenclature of the 49 species of non-Tortricidae described by Fabricius in the genus Pyralis Linnaeus, 1758 …

Dichrorampha dinarica, new species, a century of confusion in European lepidopterology (Lepidoptera: Tortricidae) resolved by combining morphology an…

2012

Dichrorampha dinarica, new species, is described from the Dinaric mountains (Macedonia, Bosnia and Herzegovina). The newspecies was formerly confused with D. ligulana (Herrich-Schäffer, 1851) from the Alps and D. rilana Drenowsky, 1909 fromthe Rila mountains (Bulgaria). Therefore, a re-description of D. rilana is provided based on topotypical specimens. The diag-nostic morphological characters of the involved species, supported by significant divergence of the mtDNA barcode (COI fragment of 658 bp), are discussed in detail.

Iperplasia midollare surrenale nei tossicodipendenti

2019

Programa de deshabituación. ¿Cuáles son los factores que llevan al dropout?

2004

La toxicodependencia, es considerada como uno de los grandes problemas de la socie¬dad actual.El internamiento de los toxicodependientes, en unidades de tratamiento de deshabi¬tuación, es uno de los modelos de intervención implantados en Portugal, como una de las formas de dar respuesta a esta problemática.Aunque la adhesión al programa de deshabituación sea significativa, cabe destacar que el cumplimiento del mismo, no siempre se verifica.Es este contexto, desenvolvemos el trabajo con el objetivo de conocer eventuales factores asociados al «dropout», es decir, salida del programa sin ser por alta clínica.Siendo un trabajo desenvuelto en el ámbito académico, fue condicionado por el tiempo d…

A Models-to-Program Information Systems Engineering Method

2021

The Model-Driven Development paradigm aims to represent all the information system features through models. Conceptual-Model Programming offers a similar approach, but with a focus on automatic code generation. Both approaches consider modeling and traceability of different abstraction levels, where each level can be tackled with different modeling methods. This heterogeneity introduces a challenge for the quality of the traceability and transformations among models, especially when aiming for automatic code generation. In this paper, we introduce a holistic conceptual-model programming method to generate code from different abstraction levels (from the problem space to the solution space),…