Search results for "COD"
showing 10 items of 2985 documents
Relevancia clínica de la selectividad de los inhibidores del cotransportador sodio-glucosa tipo 2
2016
Selectivity is the property of a drug to preferentially bind to a biological structure. Most drugs can bind and stimulate or inhibit more than one system. Therefore, it is important that they are selective for the intended site and that the doses used do not have effects on other sites, which could provoke adverse reactions. Selectivity is assessed through in vitro experiments on organs or isolated cells. If the aim is to compare drugs, the experiment should be conducted in the same tissue and with the same design. Even so, the results cannot be directly extrapolated to clinical practice due to the influence of pharmacokinetic properties, which allow an adequate dose of the drug to reach th…
Influence of Pigmentation on the Codeine Content of Hair Fibers in Guinea Pigs
1997
Tortoise shell guinea pigs (n = 7) were administered codeine (1 mg/mL codeine-base) in their drinking water for 3 weeks. Black, reddish-brown and white hair was collected separately from each animal before and after treatment. The hair samples were analyzed by GC/MS. The experiment showed positive results for all hair fibers with large individual variability of drug incorporation. Low drug intake resulted in small differences of the drug content in hair fibers different in color, whereas in cases of high drug intake a strong influence of hair pigmentation on the analytical results was observed. The highest drug content was always found in black hair samples, non-pigmented hair showed the lo…
Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells
2012
PLoS one 7(7), e40853 (2012). doi:10.1371/journal.pone.0040853
Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay
2014
The presence in the mRNA of premature stop codons (PTCs) results in protein truncation responsible for several inherited (genetic) diseases. A well-known example of these diseases is cystic fibrosis (CF), where approximately 10% (worldwide) of patients have nonsense mutations in the CF transmembrane regulator (CFTR) gene. PTC124 (3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)-benzoic acid), also known as Ataluren, is a small molecule that has been suggested to allow PTC readthrough even though its target has yet to be identified. In the lack of a general consensus about its mechanism of action, we experimentally tested the ability of PTC124 to promote the readthrough of premature termination c…
Embedded Model Control and dynamic simulation
2006
Embedded model control (EMC) is and end-to-end control technology addressed to industrial engineers and centered on the embedded model, a stylized discrete-time state equation of the whole plant, including environment, communication and computing resources. The embedded model, which is the core of the control unit, is derived and validated from a fine model of the plant which is implemented as a simulator code. The latter acts as a faithful and friendly test-bench where assessing control units before they are loaded into target processor. The paper illustrates the requirements and architecture of the EMC simulator under continuous improvement. A case study closes the paper.
Vector representation of non-standard spellings using dynamic time warping and a denoising autoencoder
2017
The presence of non-standard spellings in Twitter causes challenges for many natural language processing tasks. Traditional approaches mainly regard the problem as a translation, spell checking, or speech recognition problem. This paper proposes a method that represents the stochastic relationship between words and their non-standard versions in real vectors. The method uses dynamic time warping to preprocess the non-standard spellings and autoencoder to derive the vector representation. The derived vectors encode word patterns and the Euclidean distance between the vectors represents a distance in the word space that challenges the prevailing edit distance. After training the autoencoder o…
Trading off accuracy for efficiency by randomized greedy warping
2016
Dynamic Time Warping (DTW) is a widely used distance measure for time series data mining. Its quadratic complexity requires the application of various techniques (e.g. warping constraints, lower-bounds) for deployment in real-time scenarios. In this paper we propose a randomized greedy warping algorithm for finding similarity between time series instances. We show that the proposed algorithm outperforms the simple greedy approach and also provides very good time series similarity approximation consistently, as compared to DTW. We show that the Randomized Time Warping (RTW) can be used in place of DTW as a fast similarity approximation technique by trading some classification accuracy for ve…
"Table 2" of "Study of the Leptonic Decays of the $Z^0$ Boson"
1990
No t-channel subtraction. Statistical errors only.
"Table 1" of "Study of the Leptonic Decays of the $Z^0$ Boson"
1990
E+ E- final state is t-channel subtracted.
A quasi chemistry-transport model mode for EMAC
2010
Abstract. A quasi chemistry-transport model mode (QCTM) is presented for the numerical chemistry-climate simulation system ECHAM/MESSy Atmospheric Chemistry (EMAC). It allows for a quantification of chemical signals through suppression of any feedback between chemistry and dynamics. Noise would otherwise interfere too strongly. The signal is calculated from the difference of two QCTM simulations, a reference simulation and a sensitivity simulation. In order to avoid the feedbacks, the simulations adopt the following offline chemical fields: (a) offline mixing ratios of radiatively active substances enter the radiation scheme, (b) offline mixing ratios of nitric acid enter the scheme for re-…