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6533b872fe1ef96bd12d3922

RESEARCH PRODUCT

Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells

Carsten Müller-tidowFlorian H HeidelThomas KindlerThomas FischerMarie-christine WagnerTina M. SchnöderDaniel B. LipkaDaniel B. LipkaMarek DziadoszMirle SchemionekMirle SchemionekJunia V. MeloJunia V. MeloSteffen KoschmiederSteffen Koschmieder

subject

Drugs and DevicesDrug Research and DevelopmentTime Factorsmedicine.drug_classChronic Myeloid LeukemiaIntracellular Spacelcsh:MedicineApoptosisPharmacologyPiperazinesTyrosine-kinase inhibitorHematologic Cancers and Related DisordersCell Line TumorLeukemia Myelogenous Chronic BCR-ABL Positivehemic and lymphatic diseasesLeukemiasmedicineHumansAnnexin A5Proto-Oncogene Proteins c-abllcsh:ScienceProtein Kinase InhibitorsMyeloproliferative DisordersMultidisciplinaryABLDose-Response Relationship DrugCaspase 3Chemistrylcsh:RBiological activityImatinibHematologyrespiratory tract diseasesDasatinibKineticsPyrimidinesImatinib mesylatePharmacodynamicsBenzamidesImatinib MesylateMedicineATP-Binding Cassette Transporterslcsh:QDrug Screening Assays AntitumorSignal transductionIntracellularResearch ArticleSignal Transductionmedicine.drug

description

PLoS one 7(7), e40853 (2012). doi:10.1371/journal.pone.0040853

yearjournalcountryeditionlanguage
2012-07-01
https://dx.doi.org/10.18154/rwth-conv-074285
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