Search results for "COH"
showing 10 items of 8938 documents
Real-world experience with dupilumab in severe asthma: One-year data from an italian named patient program
2021
Raffaele Campisi,1 Claudia Crimi,1 Santi Nolasco,2 Bianca Beghè,3 Leonardo Antonicelli,4 Gabriella Guarnieri,5 Nicola Scichilone,6 Morena Porto,2 Luigi Macchia,7 Giulia Scioscia,8 Maria Pia Foschino Barbaro,8 Alberto Papi,9 Nunzio Crimi1,2 1Respiratory Medicine Unit, A.O.U. Policlinico “G. Rodolico -San Marco”, Catania, Italy; 2Department of Clinical and Experimental Medicine, Section of Respiratory Diseases, University of Catania, Catania, Italy; 3Respiratory Medicine Unit, Department of Medicine, University of Modena and Reggio Emilia, Modena, Italy; 4Allergy Unit, Department of Internal Medicine, Ancona University Hospital, Ancona, Italy; 5Department of Car…
COVID-19 in Severe Asthma Network in Italy (SANI) patients: Clinical features, impact of comorbidities and treatments
2020
To the Editor Since the end of February 2020 Italy, first non- Asian Country, has reported an ever increasing number of COronaVIrus Disease 19 (COVID-19) patients, which has reached over 200,000 confirmed Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infected subjects and resulted in more than 34000 deaths (data updated to June 19th, 20201).Patients with asthma are potentially more severely affected by by SARS-CoV-2 infection 2 and it is well established that respiratory viral infections are associated with severe adverse outcomes in patients with asthma, including increased risk of asthma exacerbation episodes 3. Nonetheless, according to the epidemiological studies publishe…
Omalizumab outcomes for up to 6 years in pediatric patients with severe persistent allergic asthma
2021
BACKGROUND: Various studies have assessed omalizumab outcomes in the clinical practice setting but follow-up and/or number of patients included were limited. We aim to describe the long-term outcomes of pediatric patients with severe persistent allergic asthma receiving omalizumab in the largest real-life cohort reported to date. METHODS: ANCHORS was a multicenter, observational, retrospective cohort study conducted in 25 Pediatric Allergy and Pulmonology units in Spain. We collected data of patients < 18 years and initiating omalizumab between 2006 and 2018, from the year prior to omalizumab initiation to discontinuation or last available follow-up. The primary outcome was the evolution of…
Sex differences in correlates of intermediate phenotypes and prevalent cardiovascular disease in the general population
2015
Background: There are marked sex differences in cardiovascular disease (CVD) manifestation. It is largely unknown how the distribution of CVD risk factors or intermediate phenotypes explain sex-specific differences. Methods and Results: In 5000 individuals of the population-based Gutenberg Health Study, mean age 55 ± 11 years, 51% males, we examined sex-specific associations of classical CVD risk factors with intima-media thickness, ankle-brachial index, flow-mediated dilation, peripheral arterial tonometry, echocardiographic, and electrocardiographic variables. Intermediate cardiovascular phenotypes were related to prevalent CVD [coronary artery disease, heart failure, stroke, myocardial i…
Microchimerism and multiple sclerosis: a study on the impact of the sex of offspring on clinical, radiological, and paraclinical features of maternal…
2023
Background. Multiple sclerosis (MS) is a chronic autoimmune disorder characterised by inflammation and neurodegeneration and representing one of the most common causes of neurologic disability among young adults. Over the last 40 years, several authors have confirmed the existence of fetal cells in maternal blood and their pregnancy-related origin, demonstrating that pregnancy may establish a long-term, low-grade chimeric state in women. The biological and clinical significance of fetal microchimeric cells (fMCs) in maternal health is largely unknown, although a role in autoimmune diseases have been hypothesised. Aims. The overarching aim of my PhD dissertation was to investigate the role o…
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
2009
We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10−7), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10−11). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10−15).
Trends analysis in the investigations realised from the data of the PISA Project
2016
Este estudio es parte de una investigación más amplia que pretende diseñar un modelo de análisis de evaluaciones de sistemas educativos que permita valorar su aportación para la cohesión social (Jornet, 2012). El punto de partida son investigaciones previas sobre el papel de las variables de contexto, de entrada y de proceso en las evaluaciones de sistemas educativos, que frecuentemente cuidan mucho más la justificación teórica y la calidad métrica de las variables de producto que estas otras, que finalmente ayudan a interpretar los resultados. En este caso realizamos revisión de los trabajos científico-académicos del corte empírico, publicados entre los años 2000 y 2012, que utilizan bases…
Dolor y recaída en el alcoholismo: alteraciones en la función moduladora del sistema opioide endógeno sobre el sistema dopaminérgico mesocorticolímbi…
2020
Durant els últims anys, múltiples estudis clínics i epidemiològics han revelat que la presència de dolor crònic està estretament relacionada amb el trastorn per consum d'alcohol (AUD). De fet, el dolor crònic sembla augmentar el risc de patir AUD i predir el consum excessiu d'alcohol i la recaiguda en aquells pacients amb antecedents d'abús d'alcohol. A més, s'ha informat que el dolor té un impacte negatiu en el processament motivacional i de recompensa, ja que altera la funció de sistema mesocorticolímbic (MCLS). Els receptors opioides mu (MOR) són components clau del MCLS i són essencials per al processament de recompenses tant d'estímuls naturals com de drogues d'abús, inclòs l'alcohol. …
Potential combined effects of maternal smoking and coffee intake on foetal death within the Danish National Birth Cohort
2018
Background: Several studies have linked coffee intake and smoking to foetal death, but a possible interaction between both exposures remains unknown.Methods: We studied, within the Danish National Birth Cohort, the potential interaction between smoking and coffee drinking while pregnant on the risk of foetal (early and late) death. The study included 90 086 pregnant women, with information about their smoking habit and coffee intake in early pregnancy, and several potential confounding factors. Interaction was studied by calculating both the hazard ratio (HR) in Cox's regression (linear and smoothed restricted cubic spline) and the interaction contrast ratio (ICR).Results: Women who neither…
Capitalismo e coesione sociale. Qualche considerazione sul ruolo attuale della sociologia
2015
Negli ultimi venti anni, grazie al predominio dell’ideologia della globalizzazione e dell’impresa globalizzata, imposto dai think thank del liberismo internazionale, e forse anche ad una eccessiva specializzazione delle scienze sociali, il tema delle disuguaglianze crescenti determinate dal modo di produzione capitalistico, e quello correlato dell’integrazione sociale e della coesione sociale all’interno dell’economia capitalistica, sono rimasti nella penombra dell’analisi delle scienze sociali e della sociologia (Bowles, 2009), in Italia (Gallino, 2012) più che in altri paesi, dove al contrario si assiste da molti anni ad una crescente attenzione nei confronti delle trasformazioni del capi…