Search results for "COMB"
showing 10 items of 7115 documents
Adjunctive Brivaracetam in Older Patients with Focal Seizures: Evidence from the BRIVAracetam add‑on First Italian netwoRk Study (BRIVAFIRST).
2022
BACKGROUND: The management of epilepsy in older adults has become part of daily practice because of an aging population. Older patients with epilepsy represent a distinct and more vulnerable clinical group as compared with younger patients, and they are generally under-represented in randomized placebo-controlled trials. Real-world studies can therefore be a useful complement to characterize the drug's profile. Brivaracetam is a rationally developed compound characterized by high-affinity binding to synaptic vesicle protein 2A and approved as adjunctive therapy for focal seizures in adults with epilepsy. OBJECTIVE: The aim of this study was to assess the 12-month effectiveness and tolerabil…
Synthesis and characterization of complexes of trialkyl- and triarylphosphine gold(I) with thiolated purines and pyrimidines. A class of bifunctional…
1991
Abstract New complexes of the type R 3 PAuL or (R 3 PAu) 2 (μ-L) where R=ethyl or phenyl and L=6-thioguanine, 2, 6- dithioxanthine, 2, 4-dithiouracil and/or dithioerythritol have been prepared. These complexes have been identified by using elemental analysis, 1 H, 13 C and 31 P NMR spectroscopy. The structures have been proposed based on these spectroscopic studies. Sulfur appears to be the binding site in disubstituted complexes of 2, 4-dithiouracil and 1, 4-dithioerythritol, while the phosphine gold( I ) moieties appear to be S and N bonded in 2, 6-dithioxanthine and 6-thioguanine. The potential use of these complexes as antitumor drugs is discussed.
ChemInform Abstract: Synthesis of the New Ring System 6,8-Dihydro-5H-pyrrolo[3,4-h]quinazoline.
2009
Abstract A convenient synthesis of the pyrrolo[3,4- h ]quinazoline ring system is reported. Our synthetic approach consisted of the annelation of a pyrimidine ring to an isoindole moiety using tetrahydroisoindole-4-ones as building blocks. The antiproliferative activity of the new compounds was investigated and one of them showed antitumor activity against all the 59 tested cell lines at micromolar concentrations (1.46–18.4 μM).
Design of new DNA-interactive agents by molecular docking and QSPR approach
2010
The design of new series of pyrrolo-pyrimidine derivatives, further annelated with a third heterocycle of different size, which also present several chain shape moieties of variable length and with different physico-chemical character, is reported. In this contribution we showed that the combination of docking-based and QSPR-based methods could lead to good models for ligand-DNA interaction prediction. By means of these computational approaches on 360 proposed inhibitors, we were able to select the most promising candidates as DNA-interactive drugs potentially endowed with antitumor activity.
The HCV Sicily Network: A web-based model for the management of HCV chronic liver diseases
2016
Epidemiological studies report that in Sicily reside about 30,000 citizens with a diagnosis of chronic hepatitis due to HCV. The availability of direct antiviral action (DAA) is a real therapeutic breakthrough, but the high cost of the therapeutic regimes limits their use and forced the National Health System to establish clinical priority for the treatment.The HCV Sicily Network is a web-based model of best medical practice, which was designed to improve the management and the treatment of HCV chronic hepatitis and cirrhosis. The network includes 41 centers and 84 gastroenterologists or infectivologists connected by a web platform that recorder the diagnosis and the clinic priority for the…
Análisis de señales biomédicas para aplicación de terapias en la fibrilación ventricular cardiaca
2017
La muerte súbita es una muerte natural, inesperada y rápida en un tiempo límite de 24 horas después del comienzo de un proceso patológico. Las causas más comunes de la muerte súbita son las enfermedades Cardiovasculares (ECV) que resultan estar entre las principales causas de muerte en todo el mundo. En 2012, la Organización Mundial de la Salud (OMS) registró 17,5 millones de muertes por ECV, que representan el 31 % de todas las muertes registradas en el mundo . Una de las enfermedades cardiovasculares con mayor mortalidad es la Fibrilación Ventricular (FV), que es una arritmia cardíaca producida por una actividad eléctrica desorganizada del corazón. Durante la FV, los ventrículos se contra…
Multiple normalized solutions for a Sobolev critical Schrödinger-Poisson-Slater equation
2021
We look for solutions to the Schr\"{o}dinger-Poisson-Slater equation $$- \Delta u + \lambda u - \gamma (|x|^{-1} * |u|^2) u - a |u|^{p-2}u = 0 \quad \text{in} \quad \mathbb{R}^3, $$ which satisfy \begin{equation*} \int_{\mathbb{R}^3}|u|^2 \, dx = c \end{equation*} for some prescribed $c>0$. Here $ u \in H^1(\mathbb{R}^3)$, $\gamma \in \mathbb{R},$ $ a \in \mathbb{R}$ and $p \in (\frac{10}{3}, 6]$. When $\gamma >0$ and $a > 0$, both in the Sobolev subcritical case $p \in (\frac{10}{3}, 6)$ and in the Sobolev critical case $p=6$, we show that there exists a $c_1>0$ such that, for any $c \in (0,c_1)$, the equation admits two solutions $u_c^+$ and $u_c^-$ which can be characterized respectively…
Lipschitz-type conditions on homogeneous Banach spaces of analytic functions
2017
Abstract In this paper we deal with Banach spaces of analytic functions X defined on the unit disk satisfying that R t f ∈ X for any t > 0 and f ∈ X , where R t f ( z ) = f ( e i t z ) . We study the space of functions in X such that ‖ P r ( D f ) ‖ X = O ( ω ( 1 − r ) 1 − r ) , r → 1 − where D f ( z ) = ∑ n = 0 ∞ ( n + 1 ) a n z n and ω is a continuous and non-decreasing weight satisfying certain mild assumptions. The space under consideration is shown to coincide with the subspace of functions in X satisfying any of the following conditions: (a) ‖ R t f − f ‖ X = O ( ω ( t ) ) , (b) ‖ P r f − f ‖ X = O ( ω ( 1 − r ) ) , (c) ‖ Δ n f ‖ X = O ( ω ( 2 − n ) ) , or (d) ‖ f − s n f ‖ X = O ( ω …
Binary Hamming codes and Boolean designs
2021
AbstractIn this paper we consider a finite-dimensional vector space $${\mathcal {P}}$$ P over the Galois field $${\text {GF}}(2),$$ GF ( 2 ) , and the family $${\mathcal {B}}_k$$ B k (respectively, $${\mathcal {B}}_k^*$$ B k ∗ ) of all the k-sets of elements of $$\mathcal {P}$$ P (respectively, of $${\mathcal {P}}^*= {\mathcal {P}} \setminus \{0\}$$ P ∗ = P \ { 0 } ) summing up to zero. We compute the parameters of the 3-design $$({\mathcal {P}},{\mathcal {B}}_k)$$ ( P , B k ) for any (necessarily even) k, and of the 2-design $$({\mathcal {P}}^{*},{\mathcal {B}}_k^{*})$$ ( P ∗ , B k ∗ ) for any k. Also, we find a new proof for the weight distribution of the binary Hamming code. Moreover, we…
Linear and cyclic radio k-labelings of trees
2007
International audience; Motivated by problems in radio channel assignments, we consider radio k-labelings of graphs. For a connected graph G and an integer k ≥ 1, a linear radio k-labeling of G is an assignment f of nonnegative integers to the vertices of G such that |f(x)−f(y)| ≥ k+1−dG(x,y), for any two distinct vertices x and y, where dG(x,y) is the distance between x and y in G. A cyclic k-labeling of G is defined analogously by using the cyclic metric on the labels. In both cases, we are interested in minimizing the span of the labeling. The linear (cyclic, respectively) radio k-labeling number of G is the minimum span of a linear (cyclic, respectively) radio k-labeling of G. In this p…