Search results for "COMB"

PEG 400/Cerium Ammonium Nitrate Combined with Microwave-Assisted Synthesis for Rapid Access to Beta-Amino Ketones. An Easy-to-Use Protocol for Discov…

2018

Compound libraries are important requirement in target-based drug discovery. In the present work, a small focused compound library based on β-aminoketone scaffold has been prepared combining microwave-assisted organic synthesis (MAOS) with polymer-assisted solution phase synthesis (PASPS) and replacing reaction workup standard purification procedures with solid phase extraction (SPE). Specifically, the effects of solvent, such as dioxane, dimethylformamide (DMF), polyethylene glycol 400 (PEG 400), temperature, irradiation time, stoichiometric ratio of reagents, and catalysts (HCl, acetic acid, cerium ammonium nitrate (CAN)) were investigated to maximize both conversion and yield. The optimi…

Isoxazolo[5,4-e]isoindole a new ring system with potent antitumor activity

2011

On the Almost Everywhere Convergence of Multiple Fourier-Haar Series

2019

The paper deals with the question of convergence of multiple Fourier-Haar series with partial sums taken over homothetic copies of a given convex bounded set $$W\subset\mathbb{R}_+^n$$ containing the intersection of some neighborhood of the origin with $$\mathbb{R}_+^n$$ . It is proved that for this type sets W with symmetric structure it is guaranteed almost everywhere convergence of Fourier-Haar series of any function from the class L(ln+L)n−1.

Frames and weak frames for unbounded operators

2020

In 2012 G\u{a}vru\c{t}a introduced the notions of $K$-frame and of atomic system for a linear bounded operator $K$ in a Hilbert space $\mathcal{H}$, in order to decompose its range $\mathcal{R}(K)$ with a frame-like expansion. In this article we revisit these concepts for an unbounded and densely defined operator $A:\mathcal{D}(A)\to\mathcal{H}$ in two different ways. In one case we consider a non-Bessel sequence where the coefficient sequence depends continuously on $f\in\mathcal{D}(A)$ with respect to the norm of $\mathcal{H}$. In the other case we consider a Bessel sequence and the coefficient sequence depends continuously on $f\in\mathcal{D}(A)$ with respect to the graph norm of $A$.

Structure of locally convex quasi C * -algebras

2008

There are examples of C*-algebras A that accept a locally convex *-topology τ coarser than the given one, such that Ã[τ] (the completion of A with respect to τ) is a GB*-algebra. The multiplication of A[τ] may be or not be jointly continuous. In the second case, Ã[*] may fail being a locally convex *-algebra, but it is a partial *-algebra. In both cases the structure and the representation theory of Ã[τ] are investigated. If Ã+ τ denotes the τ-closure of the positive cone A+ of the given C*-algebra A, then the property Ā+ τ ∩ (-Ā+ τ) = {0} is decisive for the existence of certain faithful *-representations of the corresponding *-algebra Ã[τ]

Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29

2002

Abstract ERp29 is a soluble protein localized in the endoplasmic reticulum (ER) of eukaryotic cells, which is conserved in all mammalian species. The N-terminal domain of ERp29 displays sequence and structural similarity to the protein disulfide isomerase despite the lack of the characteristic double cysteine motif. Although the exact function of ERp29 is not yet known, it was hypothesized that it may facilitate folding and/or export of secretory proteins in/from the ER. ERp29 is induced by ER stress, i.e. accumulation of unfolded proteins in the ER. To gain an insight into the mechanisms regulating ERp29 expression we have cloned and characterized the rat ERp29 gene and studied in details …

Variations of selective separability II: Discrete sets and the influence of convergence and maximality

2012

A space $X$ is called selectively separable(R-separable) if for every sequence of dense subspaces $(D_n : n\in\omega)$ one can pick finite (respectively, one-point) subsets $F_n\subset D_n$ such that $\bigcup_{n\in\omega}F_n$ is dense in $X$. These properties are much stronger than separability, but are equivalent to it in the presence of certain convergence properties. For example, we show that every Hausdorff separable radial space is R-separable and note that neither separable sequential nor separable Whyburn spaces have to be selectively separable. A space is called \emph{d-separable} if it has a dense $\sigma$-discrete subspace. We call a space $X$ D-separable if for every sequence of …

Existence de points fixes enlacés à une orbite périodique d'un homéomorphisme du plan

1992

Let f be an orientation-preserving homeomorphism of the plane such that f-Id is contracting. Under these hypotheses, we establish the existence, for every periodic orbit, of a fixed point which has nonzero linking number with this periodic orbit.

Łojasiewicz exponents, the integral closure of ideals and Newton polyhedra

2003

We give an upper estimate for the Łojasiewicz exponent $\ell(J,I)$ of an ideal $J\subseteq A(K^{n})$ with respect to another ideal I in the ring $A(K^{n})$ of germs analytic functions $f$ : $(K^{n},\mathrm{O})\rightarrow K$ , where $K=C$ or $R$ , using Newton polyhedrons. In particular, we give a method to estimate the Łojasiewicz exponent $\alpha_{0}(f)$ of a germ $f\in A(K^{n})$ that can be applied when $f$ is Newton degenerate with respect to its Newton polyhedron.

Development of polypeptide-based therapeutics for the treatment of castration resistant prostate cancer

2019

El cáncer de próstata (CaP) es el segundo cáncer más frecuente en los hombres. Los estudios han establecido el gen de fusión (T2E) compuesto por TMPRSS2 (serina proteasa dependiente de andrógenos) y ERG (factor de transcripción de la familia ETS) como un biomarcador potencial de CaP. La progresión en el CaP incluye tanto el receptor de andrógenos (AR) como el receptor del factor de crecimiento de insulina 1 (IGF-1R), y el tratamiento con un anticuerpo anti-IGF-1R (AVE1642) ha demostrado un gran potencial en el tratamiento de los pacientes con CaP T2E-positivos. Por ello, el desarrollo de terapias personalizadas basadas en polímeros terapéuticos puede favorecer el tratamiento de CaP para un …