Search results for "COMPLEMENTARITY"

Elastic plastic analysis iterative solution

1998

The step-by-step analysis of finite element elastic plastic structures subjected to an assigned (quasi-static) loading history, is considered; it identifies with the well-known sequence of linear complementarity problems. An iterative technique devoted to solve the relevant linear complementarity problem is presented. It is based on the recursive solution of a suitable linear complementarity problem, deduced from the relevant one and easier than it. The procedure convergency is proved. Some noticing particular cases are examined. The physical meaning of the procedure is shown to be a plastic relaxation. The suitable numerical ranges for some check parameter values, to be utilized in the app…

Emergency medical triage decisions are swayed by computer-manipulated cues of physical dominance in caller’s voice

2016

AbstractIn humans as well as other animals, displays of body strength such as power postures or deep masculine voices are associated with prevalence in conflicts of interest and facilitated access to resources. We conduct here an ecological and highly critical test of this hypothesis in a domain that, on first thought, would appear to be shielded from such influences: access to emergency medical care. Using acoustic manipulations of vocal masculinity, we systematically varied the perceived level of physical dominance of mock patients calling a medical call center simulator. Callers whose voice were perceived as indicative of physical dominance (i.e. those with low fundamental and formant fr…

Operator splitting methods for American option pricing

2004

Abstract We propose operator splitting methods for solving the linear complementarity problems arising from the pricing of American options. The space discretization of the underlying Black-Scholes Scholes equation is done using a central finite-difference scheme. The time discretization as well as the operator splittings are based on the Crank-Nicolson method and the two-step backward differentiation formula. Numerical experiments show that the operator splitting methodology is much more efficient than the projected SOR, while the accuracy of both methods are similar.

Mitochondrial DNA Portrait of Latvians: Towards the Understanding of the Genetic Structure of Baltic-Speaking Populations

2005

Summary Mitochondrial DNA (mtDNA) variation was investigated in a sample of 299 Latvians, a Baltic-speaking population from Eastern Europe. Sequencing of the first hypervariable segment (HVS-I) in combination with analysis of informative coding region markers revealed that the vast majority of observed mtDNAs belong to haplogroups (hgs) common to most European populations. Analysis of the spatial distribution of mtDNA haplotypes found in Latvians, as well as in Baltic-speaking populations in general, revealed that they share haplotypes with all neighbouring populations irrespective of their linguistic affiliation. Hence, the results of our mtDNA analysis show that the previously described s…

Conformation-specific blockade of the integrin GPIIb/IIIa: a novel antiplatelet strategy that selectively targets activated platelets.

2006

Platelet activation causes conformational changes of integrin GPIIb/IIIa (α IIb β 3 ), resulting in the exposure of its ligand-binding pocket. This provides the unique possibility to design agents that specifically block activated platelets only. We used phage display of single-chain antibody (scFv) libraries in combination with several rounds of depletion/selection to obtain human scFvs that bind specifically to the activated conformation of GPIIb/IIIa. Functional evaluation of these scFv clones revealed that fibrinogen binding to human platelets and platelet aggregation can be effectively inhibited by activation-specific scFvs. In contrast to clinically used GPIIb/IIIa blockers, which ar…

Antigen-Driven T-Cell Selection in Patients with Cervical Cancer as Evidenced by T-Cell Receptor Analysis and Recognition of Autologous Tumor

2002

ABSTRACTWe characterized the T-cell receptor (TCR) repertoire in freshly harvested tumor lesions, in short-term-expanded CD4+tumor infiltrating lymphocytes (TIL) as well as in CD4+and CD8+peripheral blood lymphocytes (PBL) from three patients with cervical cancer. Skewing of the T-cell repertoire as defined by measuring the length of the complementarity-determining region 3 (CDR3) of the TCR VA and VB chains was observed in CD8+PBL, in freshly harvested tumor tissue, as well as in CD4+TIL. Comparative analysis of the TCR repertoire revealed unique monoclonal TCR transcripts within the tumor lesion which were not present in PBL, suggesting selection of TCR clonotypes due to antigenic stimula…

Cytokine profile, HLA restriction and TCR sequence analysis of human CD4+ T clones specific for an immunodominant epitope of Mycobacterium tuberculos…

2003

SUMMARY The identification of immunodominant and universal mycobacterial peptides could be applied to vaccine design and have an employment as diagnostic reagents. In this paper we have investigated the fine specificity, clonal composition and HLA class II restriction of CD4+ T cell clones specific for an immunodominant epitope spanning amino acids 91–110 of the 16-kDa protein of Mycobacterium tuberculosis. Twenty-one of the tested 28 clones had a Th1 profile, while seven clones had a Th0 profile. None of the clones had a Th2 profile. While the TCR AV gene usage of the clones was heterogeneous, a dominant TCR BV2 gene family was used by 18 of the 28 clones. The CDR3 regions of BV2+ T cell c…

COMPLEMENTARITY BETWEEN LOCAL KNOWLEDGE AND INTERNATIONALIZATION IN REGIONAL TECHNOLOGICAL PROGRESS

2006

Trade, foreign direct investment, and inter-regional R&D spillovers facilitate competition, the spread of knowledge, and the adoption of more advanced technologies, which in turn hastens total factor productivity (TFP) growth. The spread of these efficiency gains from internationalization requires a sufficient local knowledge to enable them to be adapted to the domestic productive environment. Thus, higher local knowledge and internationalization will lead to TFP growth, and the greater the complementarity between variables the higher the TFP growth. We test the complementarity hypothesis using Spanish regional data over the period 1980–1995 in which both regional local knowledge and intern…

LE AREE INTERNE PER LO SVILUPPO DEL TERRITORIO E LA COMPLEMENTARITÀ DI PROGRAMMI E STRUMENTI FRA LE POLITICHE EUROPEE DI SVILUPPO RURALE E DI COESIONE

Le Aree Interne rappresentano un tema particolarmente importante per la programmazione e la spesa dei fondi comunitari nel periodo 2014-2020 perché costituiscono il più grande esempio di complementarità fra le Politiche europee di sviluppo rurale e di coesione. Per lo sviluppo di queste Aree è stata creata una Strategia Nazionale per le Aree Interne (SNAI) che mira alla valorizzazione ed al recupero di tutti quei territori (rurali, montuosi, svantaggiati) dal carattere marginale rispetto alla disponibilità e all’offerta di servizi essenziali. La peculiarità di tale Strategia è quella di promuovere lo sviluppo di aree che sono uniformemente distribuite in tutto il comprensorio nazionale a di…

Business Sectors Involved in Social Entrepreneurship

2021

The present chapter offers detailed insights about the characteristics at a microeconomic level of four practical examples of social ventures. After providing a robust theoretical framework about the motivations, challenges and aspirations of social entrepreneurs, it is time to put into practice these conceptions through the lens of real social ventures. The literature encourages the use of case studies to connect the theory groundwork, developed in the academy, to real life. As for this call to study, the present chapter thoroughly covers the ideation and consolidation stages of the selected social ventures, which sheds light for inspiration on a context where social entrepreneurship is in…