Search results for "COMPUTATION"
showing 10 items of 7362 documents
Deciphering genomic heterogeneity and the internal composition of tumour activities through a hierarchical factorisation model
2021
Genomic heterogeneity constitutes one of the most distinctive features of cancer diseases, limiting the efficacy and availability of medical treatments. Tumorigenesis emerges as a strongly stochastic process, producing a variable landscape of genomic configurations. In this context, matrix factorisation techniques represent a suitable approach for modelling such complex patterns of variability. In this work, we present a hierarchical factorisation model conceived from a systems biology point of view. The model integrates the topology of molecular pathways, allowing to simultaneously factorise genes and pathways activity matrices. The protocol was evaluated by using simulations, showing a hi…
Avaluació psicomètrica de l'estimació en numeració i càlcul a l'educació primària
2006
L'estimació en numeració i càlcul ha pres rellevància en les dues darreres dècades per la seva importància i necessitat social i, per aquest motiu, ha estat progressivament inclosa en els currículums de matemàtiques de l'educació obligatòria. Tanmateix, el treball de l'estimació a l'aula es veu reduït freqüentment a les tècniques d'arrodoniment i els alumnes no es mostren hàbils a l'hora de desenvolupar estratègies d'estimació o de decidir quan un càlcul estimat és adient per a una situació problemàtica. En aquest article es presenta un test adreçat a estudiar els processos utilitzats en tasques d'estimació en numeració i càlcul per infants que han acabat l'educació primària. S'explica el m…
A computation study to evaluate indoor gamma dose-rate on the basis of outdoor measurements
2006
A tribute to Massimo Lanza de Cristoforis
2020
It is with great pleasure that we dedicate the special issue Functional Analytic Methods in Partial Differential Equations of Complex Variables and Elliptic Equations to the 60th birthday of Massim...
Genetic structure and differentiation from early bronze age in the mediterranean island of sicily: Insights from ancient mitochondrial genomes
2022
Sicily is one of the main islands of the Mediterranean Sea, and it is characterized by a variety of archaeological records, material culture and traditions, reflecting the history of migrations and populations’ interaction since its first colonization, during the Paleolithic. These deep and complex demographic and cultural dynamics should have affected the genomic landscape of Sicily at different levels; however, the relative impact of these migrations on the genomic structure and differentiation within the island remains largely unknown. The available Sicilian modern genetic data gave a picture of the current genetic structure, but the paucity of ancient data did not allow so far to make p…
Large numbers of cold positronium atoms created in laser-selected Rydberg states using resonant charge exchange
2016
Lasers are used to control the production of highly excited positronium atoms (Ps*). The laser light excites Cs atoms to Rydberg states that have a large cross section for resonant charge-exchange collisions with cold trapped positrons. For each trial with 30 million trapped positrons, more than 700 000 of the created Ps* have trajectories near the axis of the apparatus, and are detected using Stark ionization. This number of Ps* is 500 times higher than realized in an earlier proof-of-principle demonstration (2004 Phys. Lett. B 597 257). A second charge exchange of these near-axis Ps* with trapped antiprotons could be used to produce cold antihydrogen, and this antihydrogen production is e…
Cytotoxicity of 35 medicinal plants from Sudan towards sensitive and multidrug-resistant cancer cells
2015
Abstract Background Cancer is a complex disease with multiple genetic and epigenetic alterations. Since decades, the hallmark of cancer therapy is chemotherapy. Cytotoxic drugs erase rapidly dividing cells without sufficient differentiation between normal and cancerous cells resulting in severe side effects in normal tissues. Recently, strategies for cancer treatment focused on targeting specific proteins involved in tumor growth and progression. The present study was designed to investigate the cytotoxicity of 65 crude extracts from 35 Sudanese medicinal plants towards various cancer cell lines expressing molecular mechanisms of resistance towards classical chemotherapeutics (two ATP-bindi…
Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics
2021
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Theoretical study of photoinduced ring-isomerization in the 1,2,4-oxadiazole series
2004
Abstract A theoretical study of photoinduced ring-isomerization of 3-amino-5-methyl- and 3-amino-5-phenyl-1,2,4-oxadiazoles is reported. The results well agree with the reported experimental data: in particular, they explain the ring-photoisomerization into the corresponding 2-amino-1,3,4-oxadiazoles through a ring contraction-ring expansion route; moreover, the occurrence of competing pathways involving both the ring contraction and the internal cyclization–isomerization mechanism during irradiation of the 5-alkyl substituted substrates in the presence of a base has been also substantiated.