Search results for "COMPUTATION"

InterLymph hierarchical classification of lymphoid neoplasms for epidemiologic research based on the WHO classification (2008): update and future dir…

2010

Abstract After publication of the updated World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues in 2008, the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph) now presents an update of the hierarchical classification of lymphoid neoplasms for epidemiologic research based on the 2001 WHO classification, which we published in 2007. The updated hierarchical classification incorporates all of the major and provisional entities in the 2008 WHO classification, including newly defined entities based on age, site, certain infections, and molecular characteristics, as well as borderline categories, early and “in situ” …

Personalized Cardiac Computational Models: From Clinical Data to Simulation of Infarct-Related Ventricular Tachycardia.

2019

In the chronic stage of myocardial infarction, a significant number of patients develop life-threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled myocardium. Radiofrequency ablation (RFA) is a common procedure to isolate reentry pathways across the infarct scar that are responsible for VT. Unfortunately, this strategy show relatively low success rates; up to 50% of patients experience recurrent VT after the procedure. In the last decade, intensive research in the field of computational cardiac electrophysiology (EP) has demonstrated the ability of three-dimensional (3D) cardiac computational models to perform in-silico EP studies. However, the personal…

Circulating irisin detection: Does it really work?

2015

The recent discovery of irisin has generated considerable interest in the scientific community. However, many studies on the biochemistry and biology of this intriguing hormone yielded controversial results in humans, which were mostly attributable to a number of drawbacks in the methods used for its detection and measurement.

Modelling cardiac mechanics of left ventricular noncompaction

2020

Left ventricular noncompaction (LVNC) can be defined as a cardiomyopathy characterised by a pattern of prominent trabecular structure and deep intertrabecular recesses, that is thought to be caused by an arrest of normal endomyocardial morphogenesis. Using patient-specific computational modelling, we assessed the cardiac mechanics of five patients with LVNC and compared myocardial stress and pump performance to those of healthy controls. Findings shown that patients with LVNC have impaired left ventricular (LV) function, making it possible that the lack of fibre shortening of noncompacted layer can determine poor heart function. Pronounced end-systolic wall stress on left ventricular wall o…

Postoperative Lens Position Preoperatively Determined by Scheimpflug Photography

1999

The position of the artificial lens has an important influence on refractive power calculation. We compared the position of the crystalline lens with that of the artificial lens after cataract surgery by means of Scheimpflug photography. A difference in position of approximately 0.8 mm in the anterior direction could be determined.

Embryologic outcome and secretome profile of implanted blastocysts obtained after coculture in human endometrial epithelial cells versus the sequenti…

2008

Objective To compare embryologic and clinical outcomes in terms of preimplantation development, implantation, pregnancy rates, and secretome profile of implanted blastocysts from the preimplantation genetic diagnosis program grown in sequential versus endometrial epithelial cell (EEC) coculture system. Design Retrospective clinical study and prospective experimental study. Setting In vitro fertilization clinical unit and university research laboratory. Intervention(s) Blastomere biopsy, embryo culture, blastocyst transfer, and protein analysis of the media conditioned from implanted embryos obtained from coculture and sequential systems. Main Outcome Measure(s) Clinical study: blastocyst, i…

Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells

2013

Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC. However, although sorafenib is well tolerated, concern for its safety has been expressed. Celecoxib (Celebrex®) is a selective cyclooxygenase-2 (COX-2) inhibitor which exhibits antitumor effects in human HCC cells. The present study examined the interaction between celecoxib and sorafenib in two human liver tumor cell lines HepG2 and Huh7. Our data showed that each inhibitor alone reduced cell growth and the combination of celecoxib with sorafenib synergistically inhibited cell growth an…

Parallel global optimization : structuring populations in differential evolution

2010

On automatic algorithm configuration of vehicle routing problem solvers

2019

Many of the algorithms for solving vehicle routing problems expose parameters that strongly influence the quality of obtained solutions and the performance of the algorithm. Finding good values for these parameters is a tedious task that requires experimentation and experience. Therefore, methods that automate the process of algorithm configuration have received growing attention. In this paper, we present a comprehensive study to critically evaluate and compare the capabilities and suitability of seven state-of-the-art methods in configuring vehicle routing metaheuristics. The configuration target is the solution quality of eight metaheuristics solving two vehicle routing problem variants.…

Interactive data-driven multiobjective optimization of metallurgical properties of microalloyed steels using the DESDEO framework

2023

Solving real-life data-driven multiobjective optimization problems involves many complicated challenges. These challenges include preprocessing the data, modelling the objective functions, getting a meaningful formulation of the problem, and supporting decision makers to find preferred solutions in the existence of conflicting objective functions. In this paper, we tackle the problem of optimizing the composition of microalloyed steels to get good mechanical properties such as yield strength, percentage elongation, and Charpy energy. We formulate a problem with six objective functions based on data available and support two decision makers in finding a solution that satisfies them both. To …