Search results for "CONCISE"
showing 7 items of 7 documents
Diastereoselective synthesis of 6-functionalized 4-aryl-1,3-oxazinan-2-ones and their application in the synthesis of 3-aryl-1,3-aminoalcohols and 6-…
2010
Abstract Halocyclocarbamation of benzyl N -(1-phenyl-3-butenyl)carbamates afforded 6-functionalized 4-aryl-1,3-oxazinan-2-ones with moderate to excellent diastereoselectivity depending on the N -substituent. Importantly, in contrast to reported cyclocarbamations of homoallylic carbamates, which are generally trans -diastereoselective, cyclization of N -unsubstituted Cbz-protected homoallylamines led to cis -1,3-oxazinan-2-ones, predominantly. The use of N -benzylated and in situ prepared N -silylated derivatives resulted however in trans -selectivity. Transition states are proposed to explain the stereochemical influence of the N -substituent on the cyclocarbamations. The functionalized 1,3…
No primary association between LMP2 polymorphisms and extraspinal manifestations in spondyloarthropathies
1997
OBJECTIVE—To investigate the potential role of the HLA-linked LMP2 (low molecular weight protein) gene polymorphisms in conjunction with DR4 and DR7 on extraspinal disease manifestations in HLA-B27 positive patients with spondyloarthropathy. METHODS—172 patients with spondyloarthropathy, 46 healthy, HLA-B27 positive blood donors, and 99 unrelated controls were typed for HLA-class I and II antigens. LMP2 alleles were determined by polymerase chain reaction and subsequent restriction enzyme digestion. RESULTS—There were statistically non-significant increases of DR4 and DR7 in spondyloarthropathy subjects. However these differences did not relate to specific extraspinal manifestations. There …
Long term structural effects of combination therapy in patients with early rheumatoid arthritis: five year follow up of a prospective double blind co…
2003
Objective: To evaluate whether early combined therapy with methotrexate (MTX) and sulfasalazine (SSZ) during the first year in early rheumatoid arthritis (RA) induces long term beneficial effects, compared with monotherapy, when the further treatment strategy is a free choice. Methods: Study design: five year multicentre prospective longitudinal trial. Participants: 146/205 patients with RA previously included in a one year prospective randomised trial comparing the effects of treatment with MTX, SSZ, or a combination of both. Criteria for inclusion: patients with early RA (⩽1 year duration). Follow up: between the end of years 1 and 5, patients were followed up and treated by their own rhe…
Communication role on perception and beliefs of EU citizens about science
2020
Este documento presenta un conjunto de recomendaciones basadas en el conocimiento de las consultas públicas de CONCISE. Los puntos se enumeran según los diferentes destinatarios: comunicadores científicos, responsables políticos, científicos y público en general. El principal objetivo de CONCISE es determinar el papel que desempeña la comunicación científica en la formación de creencias, percepciones y conocimientos sobre cuestiones científicas. Para lograr este objetivo, CONCISE llevó a cabo cinco consultas públicas en Lisboa (Portugal), Valencia (España), Vicenza (Italia), Trnava (Eslovaquia) y Lodz (Polonia) con la participación de cerca de 500 ciudadanos. Esto permitió al consorcio reco…
La détermination passive et quelques thématisations particulières en anglais médical
1997
À partir d’exemples caractéristiques issus d’un corpus de 2 115 structures passives tirées de la revue britannique The Lancet, j’ai réalisé une classification originale de ces diathèses passives en trois grandes catégories, à savoir la détermination passive simple, la détermination passive complexe et la détermination passive tronquée. Après avoir précisé en quoi ces opérations de détermination correspondaient à une stratégie énonciative particulière — qu’elle soit réfléchie ou spontanée — mise en œuvre par les médecins, j’ai analysé quelques formes extrêmes, ou déterminations particulières, notamment celles présentées sous la forme d’adjectifs composés. Thanks to 2,115 passive structures c…
El papel que desempeña la comunicación de la ciencia en la opinión de la ciudadanía europea
2020
El documento recoge las recomendaciones políticas recomendadas a partir de los resultados de investigación del proyecto europeo H2020 CONCISE. En este proyecto se llevaron a cabo cinco consultas ciudadanas, en cinco ciudades europeas de España, Italia, Eslovaquia, Portugal y Polinia), en las que participaron alrededor de 100 ciudadanos en cada una de ellas, para hablar sobre ciencia. Concretamente a los ciudadanos se les preguntó cómo se informaban y en qué fuentes o canales confiaban más para informarse de temas como las vacunas, el cambio climático, las medicinas complementarias o alternativas, y los organismos modificados genéticamente. Los debates arrojaron información muy valiosa para …
Etanercept maintains the clinical benefit achieved by infliximab in patients with rheumatoid arthritis who discontinued infliximab because of side ef…
2007
Objective: To evaluate the efficacy of switching to etanercept treatment in patients with rheumatoid arthritis who already responded to infliximab, but presented side effects. Methods: Charts of 553 patients with rheumatoid arthritis were retrospectively reviewed to select patients who responded to the treatment with infliximab and switched to etanercept because of occurrence of adverse effects. Clinical data were gathered during 24 weeks of etanercept treatment and for the same period of infliximab treatment before infliximab was stopped. Disease Activity Score computed on 44 joints (DAS-44), erythrocyte sedimentation rate (ESR) 1st hour, Visual Analogue Scale (VAS) of pain, Health Assessm…