Search results for "CONSTITUTION"
showing 10 items of 568 documents
Indulto y Poder Judicial: ¿Un instrumento para la realización de la Justicia?
2017
El indulto no es un vestigio histórico. su reconocimiento en la totalidad de los textos constitucionales de nuestra historia, advierte la existencia de una necesidad que es satisfecha por el indulto, con independencia del momento en el que se haya aplicado. el indulto ex- presa el desajuste entre la norma penal y la justicia, que solo puede tener su remedio con el otorgamiento de la gracia. Pero la admisibilidad del indulto exige el pleno so- metimiento a la ley y al principio de legalidad, desde un ejercicio restrictivo y excepcional, por tratarse de una potestad extraordinaria, pues determina una alteración de los principios constitucionales. y sólo en la medida que sea el Poder Judicial …
Ciencia de la Sostenibilidad: ¿Una nueva disciplina o un nuevo enfoque para todas las disciplinas?
2015
Al inicio de este siglo XXI comenzó a desarrollarse un nuevo dominio científico, la Ciencia de la Sostenibilidad, con el objetivo explícito de hacer frente a la actual situación de emergencia planetaria e impulsar la transición a sociedades sostenibles. Una nueva forma de hacer ciencia para un nuevo período de la historia de la humanidad, el Antropoceno, en el que el planeta está experimentando grandes cambios, debidos principalmente a la acción de los seres humanos, que amenazan la supervivencia de la propia especie humana. Nuestro propósito en este trabajo ha sido analizar en qué medida esta Ciencia de la Sostenibilidad puede realmente contribuir a la necesaria transición a la Sostenibili…
Bndocrinopathic Constitutions and Pathology of War*
1919
The clinical study of the internal secretions opens a vast field of research, so far little known, notwithstanding its great value in practical medicine. Particularly important are those states of hormonic imbalance which are at the border line between health and disease, and which represent either latent or mild endocrinopathic conditions, real endocrine diatheses or endocrinopathic temperaments. It is already understood that for each of the best known endocrine glands, in addition to frank malfunctions there must be recognized minor degrees of perturbation giving rise to the endocrinopathic habitus. To the French writers, especially Levi and Rotschild, we owe much of our knowledge of the …
Splenic Marginal Zone Lymphoma: French Registries Population-Based Treatment and Survival Analyses (2002-2014)
2020
Background. Splenic Marginal Zone Lymphoma (SMZL) is a rare indolent B-cell lymphoma characterized by a massive splenomegaly and a moderate lymphocytosis. There is no standard of care for SMZL so far. The treatment is indicated if constitutional symptoms, massive splenomegaly and/or cytopenia, after a watch and wait period that is highly variable. Rituximab with or without chemotherapy, chemotherapy, and splenectomy are valid treatment approaches. Our objectives were to describe the characteristics of the patients with SMZL retrospectively collected from a French population database, to analyze the treatments received in first line (Tt1) and in second line (Tt2) in term of efficacy, and to …
Ruxolitinib Plus Pomalidomide in Myelofibrosis: Updated Results from the Mpnsg-0212 Trial (NCT01644110)
2016
Abstract Background: Although ruxolitinib (RUX) reduces constitutional symptoms and splenomegaly in myelofibrosis (MF) therapy options for anemia are limited. In our prior MPNSG-0109 trial of pomalidomide (POM) in MF with cytopenia, anemia responses were reported in 14% and 29% of subjects receiving POM 0.5 mg/d and 2 mg/d, respectively (Schlenk RF et al., ASH 2013, abstract #2822). We designed a phase-Ib/-II combination study of RUX plus POM to evaluate synergistic effects in subjects with anemia and splenomegaly (MPNSG-0212 trial, NCT01644110; Stegelmann et al., ASH 2015, abstract #826). Study Design: Primary endpoints are response rate after 12 treatment cycles (28 days each) according t…
Physical Condition Factors that Predict a Better Quality of Life in Women with Fibromyalgia
2019
What physical qualities can predict the quality of life (QoL) in women with fibromyalgia (FM)? QoL is a very complex outcome affected by multiple comorbidities in people with fibromyalgia. This study aims to determine which physical qualities can predict the quality of life in women with FM. Also, a comparison between the physical qualities of women with FM and healthy counterparts was conducted. In total, 223 women participated in this cross-sectional study, 123 with FM, with ages ranging between 45 and 70 years. The study was conducted at several fibromyalgia associations and specialized medical units. QoL was measured as the main outcome. In addition, functional capacity, muscular streng…
CD4saurus Rex & HIVelociraptor vs. development of clinically useful immunological markers: a Jurassic tale of frozen evolution.
2011
Abstract One of the most neglected areas of everyday clinical practice for HIV physicians is unexpectedly represented by CD4 T cell counts when used as an aid to clinical decisions. All who care for HIV patients believe that CD4+ T cell counts are a reliable method to evaluate a patient immune status. There is however a fatalistic acceptance that besides its general usefulness, CD4+ T cell counts have relevant clincal and immunological limits. Shortcomings of CD4 counts appear in certain clinical scenarios including identification of immunological nonresponders, subsequent development of cancer on antiretroviral teatment, failure on tretment simplification. Historical and recently described…
Patient preferences in the treatment of hemophilia A: impact of storage conditions on product choice
2018
Bernd Tischer,1 Renato Marino,2 Mariasanta Napolitano3 1Kantar Health, Munich, Germany; 2Haemophilia and Thrombosis Centre, University Hospital of Bari, Apulia, Italy; 3University of Palermo, Reference Regional Center for Thrombosis and Hemostasis Hematology Unit, Palermo, Italy Objectives: To gain insights into the usage of factor VIII (FVIII) products by patients diagnosed with moderate/severe hemophilia A, and to assess the impact and perceived importance of product storage.Methods: In this study, 200 patients diagnosed with moderate or severe hemophilia A across seven countries participated. Data were collected via a 30-minute, face-to-face interview in six countries and via a web-based…
Guillain-Barré syndrome after orthotopic liver transplantation: A clinical manifestation of immune reconstitution inflammatory syndrome?
2018
Guillain-Barrè Syndrome, as part of the spectrum of dysimmune neuropathies, is unexpected to occur in immunocompromised hosts. We describe a clinical case of Guillain-Barrè syndrome, occurred a few weeks after a liver transplant, and we postulate that our case would satisfy all requirements to explain this peripheral nervous system complication as a clinical manifestation of an Immune reconstitution inflammatory syndrome. In this setting of liver transplantation, complicated by potentially multiple infective triggers, reduction of immunosuppression and reversal of pathogen-induced immunosuppression, through antimicrobial therapy, may have led to pro-inflammatory response. The pro-inflammato…
O poder moderador das forças armadas no Brasil. Uma leitura do General Bertholdo Klinger e da revista militar A Defeza Nacional (1913-1932)
2023
Organe des « Jeunes-Turcs », ces officiers réformateurs brésiliens partis en Allemagne entre 1906 et 1912 pour finaliser leur formation, la revue militaire A Defeza Nacional demeure aujourd’hui l’un des principaux lieux d’exposition de la doctrine des forces armées. Dirigée par Bertholdo Klinger, elle popularisa la thèse du pouvoir conservateur des militaires, moins sous l’angle constitutionnel que sous l’aspect social, du fait des interférences du « pouvoir spirituel » du positivisme comtien.