Search results for "CONTRACT"
showing 10 items of 1719 documents
Selective chiral inhibition of Ca2+ entry promoted by bisbenzyltetrahydroisoquinolines in rat uterus.
1992
Abstract The effects of diltiazem and six bisbenzyltetrahydroisoquinoline alkaloids (antioquine, 7-O-methylantioquine, dimethylantioquine, monterine, granjine and cordobimine) were studied in rat isolated uterus in order to clarify the mechanisms of their relaxant actions. All the compounds tested completely relaxed KCl-induced contractions and totally or partially inhibited oxytocin-induced rhythmic contractions. Only alkaloids with absolute configurations (1R,1′S or 1R,1′R) acted intracellularly, promoting relaxation of contractile responses induced by oxytocin in a Ca2+-free medium, as does papaverine. Alkaloids of the antioquine series (1S,1′R) selectively inhibited Ca2+ entry. The grea…
Effects of sulphonylureas on spontaneous motility and induced contractions in rat isolated uterus
1986
Abstract To clarify the action of sulphonylureas on calcium, the effect of tolbutamide and ghbenclamide has been investigated on a Ca-dependent process, the contractile activity of uterine smooth muscle. Both sulphonylureas antagonized the contractions evoked by CaCl2 in a non-competitive manner when the uterus was maintained in depolarizing solution and did not affect the spontaneous contractions of rat uterus. The capacity of tolbutamide and ghbenclamide to relax vanadate-induced contraction of rat uterus in Ca-free medium suggests that sulphonylureas may have an intracellular site of action related to cytosolic free Ca levels, or effect a reduction in Ca action.
Relaxation induced by N-terminal fragments of chromogranin A in mouse gastric preparations.
2007
Abstract A definitive role for chromogranin A (CGA)-derived fragments in the control of the gastrointestinal smooth muscle contractility has not been yet established. The purpose of the present study was to evaluate, in vitro , the effects of the recombinant vasostatin 1–78 (VS-1), CGA 7–57 and CGA 47–66 on the mouse gastric mechanical activity, recording the changes of intraluminal pressure. VS-1, CGA 7–57 and CGA 47–66 produced concentration-dependent relaxations. Mouse anti-vasostatin-1 monoclonal antibody 5A8, recognising the region 53–57, abolished the relaxation induced by VS-1, indicating the specificity of the effect. The relaxation was significantly reduced by tetrodotoxin (TTX), b…
Muscle function in monozygotic female twin pairs discordant for hormone replacement therapy
2011
Introduction: Postmenopausal monozygotic twin pairs discordant for hormone replacement therapy (HRT) provide an advantageous study design controlling for genetic background for elucidating the relationships between aging, sex hormone levels, muscle strength, contractile capacity, and fatigability. Methods: Thirteen postmenopausal monozygotic twin pairs discordant for HRT were measured for maximal voluntary torque (MVC) and twitch characteristics using electrical stimulation before and after intermittent dynamic plantarflexor exercise until exhaustion. Results: Peak twitch torque was 32% higher in HRT users than in their non-HRT, genetically identical sisters (P = 0.002), but MVC did not dif…
Union representation and prevention of occupational risks during the crisis: impact and limits
2019
La investigación que presentamos estudia el impacto de la intervención sindical en materia de salud laboral, en lo que se refiere tanto a la gestión preventiva y creación de una cultura participativa como en los procesos de vigilancia y control de las condiciones de trabajo. A tal efecto, se han consultado las principales encuestas nacionales e internacionales sobre gestión de riesgos laborales en las empresas, analizando los datos más relevantes en base a modelos de regresión logística y lineal, lo que ha permitido constatar que la representación sindical de los trabajadores en la empresa (generalista y especializada) correlaciona positivamente con el desarrollo de las principales dimensio…
Attività extralavorativa durante l'infortunio, obblighi contrattuali e doveri di correttezza e buona fede
2021
Il contributo, a partire da una pronuncia del Tribunale di Roma, affronta la questione della legittimità del licenziamento per giusta causa di un lavoratore, che svolga attività lavorativa presso terzi o extra lavorativa, quando sia infortunato e perciò assente dal lavoro. The essay deals with the legitimacy of dismissal for cause, starting from a decision of the Court of Rome. It’s about an employee who carries out other work or does some extracurriculars, when he is out sick.
Sécurité juridique et relations commerciales internationales
2006
Colloque des 26 et 27 octobre 2006; National audience
Los Derechos Humanos en la Filosofía Analítica: Ronald Dworkin
2013
Este artículo atiende la manera en que Ronald Dworkin –como H. L. A. Hart y John Rawls, a quienes él sigue– enuncia el fundamento de los derechos humanos. Cierta presencia de iusnaturalismo en ese fundamento es señalado por Dworkin, Hart y Rawls y ellos buscan cuáles serían los derechos naturales del hombre (uno de ellos dice que sería la libertad y los otros dos dicen que sería la igualdad), i.e., ellos son derechos que no pueden depender de un contrato social porque ellos son primeros para estos y son presupuestos; debido a esto, ellos no pueden depender de la sola positivación. Hay, entonces, un iusnaturalismo escondido o latente en el fundamento de los derechos humanos como derechos mor…
Fixed point results for α-implicit contractions with application to integral equations
2016
Recently, Aydi et al. [On fixed point results for α-implicit contractions in quasi-metric spaces and consequences, Nonlinear Anal. Model. Control, 21(1):40–56, 2016] proved some fixed point results involving α-implicit contractive conditions in quasi-b-metric spaces. In this paper we extend and improve these results and derive some new fixed point theorems for implicit contractions in ordered quasi-b-metric spaces. Moreover, some examples and an application to integral equations are given here to illustrate the usability of the obtained results.
Il contratto a termine nelle fondazioni liriche
2020
The discipline of the fixed term contracts in opera foundations has been repeatedly modified in the last years. The attempts of the legislator to avoid the application of ordinary rules to these subjects has been nullified by the European Court of Justice. It has been therefore introduced a new regulation, that applies to these contracts some of the limits provided for in EU Directive 1999/70, but not the sanction of the conversion of the fixed term contract into a contract of indeterminate duration, in case of violation of the above mentioned limits. The workers have rights only to a monetary compensation, that can be considered an effective protection to unlawful use of flexible contracts.