Search results for "COPD"

showing 10 items of 483 documents

Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-…

2021

Obesity has complex links to respiratory health. Mendelian randomization (MR) enables assessment of causality of body mass index (BMI) effects on airflow obstruction and mid-expiratory flow. In the adult SAPALDIA cohort, recruiting 9,651 population-representative samples aged 18–60 years at baseline (female 51%), BMI and the ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) as well as forced mid-expiratory flow (FEF25–75%) were measured three times over 20 follow-up years. The causal effects of BMI in childhood and adulthood on FEV1/FVC and FEF25–75% were assessed in predictive (BMI averaged over 1st and 2nd, lung function (LF) averaged over 2nd and 3rd fol…

Vital capacityPulmonary Disease Chronic Obstructive0302 clinical medicinePULMONARY-DISEASEMedicineLungPublic Environmental & Occupational HealthOriginal Research2. Zero hungerRISK0303 health sciencesCOPDInstrumental variableAge Factorslongitudinal cohortgenetic score3. Good healthOBESITYCohortLife course approachFemalePublic HealthPublic aspects of medicineRA1-1270Life Sciences & BiomedicineAdultbody mass index1117 Public Health and Health Services03 medical and health sciencesFEV1/FVC ratioMendelian randomizationLUNG-FUNCTION DECLINEMendelian randomizationQUALITYHumansCOPDGENOME-WIDE ASSOCIATION030304 developmental biologyScience & Technologybusiness.industryPublic Health Environmental and Occupational Healthnutritional and metabolic diseaseslung functionADULTSMendelian Randomization Analysismedicine.diseaseCross-Sectional Studies030228 respiratory systemASTHMAbusinessFOLLOW-UPBody mass indexDemographyFrontiers in Public Health
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Relationship among Body Composition, Adipocytokines, and Irisin on Exercise Capacity and Quality of Life in COPD: A Pilot Study

2022

Adipose tissue is an endocrine organ that interferes with the severity of chronic obstructive pulmonary disease (COPD). Although inflammatory markers, body composition, and nutritional status have a significant impact on pulmonary function, the real contribution of adipocytokines and myokines in COPD is still controversial. We aimed to evaluate the role played by the body composition, leptin, adiponectin, haptoglobin, and irisin on the functional exercise capacity, respiratory function, and quality of life (QoL) in COPD. In 25 COPD (20% GOLD-1; 60% GOLD-2; 20% GOLD-3) patients and 26 matched control subjects, we find that leptin, total adiponectin and haptoglobin are significantly increased…

adipocytokines; adiponectin; body composition; COPD; haptoglobin; irisin; leptin; quality of life; 6 min walking testMolecular BiologyBiochemistryBiomolecules
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Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI.

2009

Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C…

aged; analysis of variance; antigens; blood; blood cell count; body mass index; bone marrow transplantation; case-control studies; cd; chronic obstructive; chronic obstructive pulmonary disease; colony-forming units assay; creatine kinase; cytokines; endothelial cells; enzyme-linked immunosorbent assay; fat-free mass; female; humans; intercellular signaling peptides and proteins; lactate dehydrogenases; low-bmi copd; male; metabolism; methods; middle aged; normal-bmi copd; physiology; physiopathology/surgery; pulmonary disease; severity of illness index; statistics as topicMalePathologyPhysiologyStatistics as TopicCD34GastroenterologySeverity of Illness IndexBody Mass IndexPulmonary Disease Chronic Obstructiveantigenslow-bmi copdnormal-bmi copdCreatine Kinasepulmonary diseaseBone Marrow TransplantationCOPDchronic obstructiveGeneral NeuroscienceRespiratory diseaseMiddle Agedcdfat-free massHaematopoiesismedicine.anatomical_structurephysiopathology/surgeryCytokinesIntercellular Signaling Peptides and ProteinsFemalePulmonary and Respiratory Medicinemedicine.medical_specialtyEnzyme-Linked Immunosorbent Assaymacromolecular substancesSettore MED/10 - Malattie Dell'Apparato Respiratoriochronic obstructive pulmonary diseasemethodsColony-Forming Units AssayChronic obstructive pulmonary disease low-BMI COPD normal-BMI COPD fat-free massbloodAntigens CDInternal medicineSeverity of illnessmedicineHumansProgenitor cellLactate DehydrogenasesAgedAnalysis of Variancebusiness.industryCase-control studyEndothelial Cellsmedicine.diseaseBlood Cell CountCase-Control StudiesBone marrowbusinessmetabolismRespiratory physiologyneurobiology
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Airway wall thickness by HRCT in patients with COPD.

2008

airway HRCT COPD
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Oxidative Stress in COPD.

2019

Numerous studies over the years have shown that oxidative stress plays a major role in the development of the disease. Oxidative stress involvement in COPD opens up the possibility of using antioxidant therapies in the treatment of the disease. However, so far, these therapies have shown no clinical benefit indicating that more basic research efforts are needed to understand the underlying mechanisms by which oxidative stress leads to the development of COPD.

alpha-1 antitrypsin deficiency0303 health sciencesCOPDAntioxidantAlpha 1-antitrypsin deficiencybusiness.industrymedicine.medical_treatmentGeneral MedicineDiseaseBioinformaticsmedicine.diseasemedicine.disease_cause03 medical and health sciences0302 clinical medicineEditorialantioxidants030228 respiratory systemBasic researchmedicineoxidative stressCOPDbusinessOxidative stress030304 developmental biologyJournal of clinical medicine
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The asthma-COPD overlap syndrome (ACOS): hype or reality? That is, a curiosity for the media or an opportunity for physicians?

2014

Asthma-COPD Overlap Syndrome (ACOS) has been recently defined as a new pathological entity. Most studies support a large difference in the pathophysiology of bronchial asthma and chronic obstructive pulmonary disease (COPD). However, there is evidence of an increasing prevalence of patients in whom the two diseases coexist or in which one condition evolves into the other, leading to the pathological condition named ACOS. This occurs mainly in individuals with long-standing asthma, especially if also current or former-smokers. Indeed, epidemiological studies show that aging is one of the main risk factors for ACOS, creating the basis for the two entities to converge on the same subject. It i…

asthma COPD lung function airway inflammation quality of life acute exacerbations
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Beta-Blocker Use in Older Hospitalized Patients Affected by Heart Failure and Chronic Obstructive Pulmonary Disease: An Italian Survey From the REPOS…

2022

Beta (β)-blockers (BB) are useful in reducing morbidity and mortality in patients with heart failure (HF) and concomitant chronic obstructive pulmonary disease (COPD). Nevertheless, the use of BBs could induce bronchoconstriction due to β2-blockade. For this reason, both the ESC and GOLD guidelines strongly suggest the use of selective β1-BB in patients with HF and COPD. However, low adherence to guidelines was observed in multiple clinical settings. The aim of the study was to investigate the BBs use in older patients affected by HF and COPD, recorded in the REPOSI register. Of 942 patients affected by HF, 47.1% were treated with BBs. The use of BBs was significantly lower in patients with…

beta-blockersREPOSI registerCOPDheart failurebeta-blockers clinical practice COPD heart failure REPOSI registerCardiology and Cardiovascular Medicineclinical practice
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Glycoproteins In Large And Small Airways And In Lung Parenchyma Of COPD Patients

2011

chemistry.chemical_classificationPathologymedicine.medical_specialtyBPCOchemistrySmall airwaysbusiness.industryCopd patientsParenchymamedicineSettore MED/10 - Malattie Dell'Apparato RespiratoriobusinessGlycoprotein
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Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome

2021

Background and Objectives: Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are usually associated with multi-morbidity. The aim of this study was to retrospectively investigate the prevalence of comorbidities in a cohort of patients with OSAS and COPD-OSAS overlap syndrome (OS) patients and to explore differences between these two groups. Materials and Methods: Included were consecutive OS patients and OSAS patients who had been referred to our sleep laboratory, and were matched in terms of sex, age, BMI, and smoking history. Presence of comorbidities was recorded based on their medical history and after clinical and laboratory examination. Results: …

comorbiditiemedicine.medical_specialtyMedicine (General)obstructive sleep apnea syndromeComorbiditySettore MED/10 - Malattie Dell'Apparato Respiratoriooverlap syndromecomorbiditiesArticlechronic obstructive pulmonary diseaseFEV1/FVC ratioPulmonary Disease Chronic ObstructiveR5-920cardiovascular diseaseInternal medicinemedicineHumansRetrospective StudiesCOPDSleep Apnea Obstructivebusiness.industryOverlap syndromeGeneral Medicinemedicine.diseaseComorbiditynervous system diseasesRespiratory Function Testsrespiratory tract diseasesObstructive sleep apneaApnea–hypopnea indexCohortbusinessDyslipidemiaMedicina
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Safety of tiotropium and olodaterol fixed-dose combination for COPD in patients on β-blockers

2015

Introduction: The TONADO studies (NCT01431274; NCT01431287) established the efficacy and safety of a new once-daily fixed-dose combination (FDC) with tiotropium (T), a long-acting muscarinic antagonist, and olodaterol (O), a long-acting β 2 -agonist, for the treatment of COPD. This post hoc analysis evaluates T+O safety in the subgroup of patients (pts) receiving β-blockers (BBs) in these studies. Methods: These were randomised, double-blind, parallel-group, 52-week, Phase III trials comparing T+O FDC (2.5/5 µg; 5/5 µg) with the monocomponents. Adverse events (AEs) and serious AEs (SAEs) were recorded and SAEs independently adjudicated. Pooled safety data from pts receiving BBs at baseline …

congenital hereditary and neonatal diseases and abnormalitiesCOPDmedicine.medical_specialtybusiness.industryIncidence (epidemiology)Fixed-dose combinationOlodaterolMuscarinic antagonistmedicine.diseasechemistry.chemical_compoundchemistryInternal medicinePost-hoc analysisMedicineIn patientbusinessAdverse effectmedicine.drug5.1 Airway Pharmacology and Treatment
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