Search results for "COPI"
showing 10 items of 2618 documents
Biologic effects of ultrasound on liver cells of rat embryos.
1987
Experiments on the biologic effects of ultrasound (US) were carried out on rat embryos exposed for 120 s to a US beam showing features similar to those already employed for diagnostic purposes. Electron microscopic investigation of the liver parenchyma of rat embryos confirmed results obtained from adult guinea pigs with the same duration of exposure, i.e. diffuse vacuolization of cytoplasma and varying degrees of mitochondrial damage.
Quantitative bioluminescence imaging--a method for the detection of metabolite distributions in frozen tissues
1994
A novel technique allows for measurement of metabolite distributions in tissue cryosections at a microscopic level using bioluminescence, single photon imaging, and computerized image analysis. Metabolites, such as ATP, glucose and lactate are registered in absolute concentration units, and the respective images can be correlated with each other and with histological structures by specific algorithms. One striking difference between malignant tumors and normal tissue is the pronounced heterogeneity of metabolite distributions in malignancies contrasted by rather homogeneous patterns obtained in many normal organs. The heterogeneous distribution of metabolites in solid tumors reflects the ch…
Diagnosing early Barrett’s neoplasia and oesophageal squamous cell neoplasia by bioimpedance spectroscopy in human tissue
2013
Background: Detection of early oesophageal cancer in surrounding normal tissue can be challenging, but detection is essential to determine the subsequent treatment. Dysplastic tissue can be detected by using electrical impedance spectroscopy (EIS). Objective: The aim of the present study was to evaluate the feasibility and value of EIS in the diagnosis of oesophageal neoplasia. Methods: This prospective ex-vivo study included 23 patients with early oesophageal cancer (17 with Barrett’s cancer and six with early squamous cell cancer). Immediately after endoscopic resection, the electrical properties of the resected specimens were investigated using a pencil probe (5 mm in diameter, frequency…
Möglichkeiten und Grenzen der Mikrogefäßdarstellung
2005
Vessel systems and the microvascular unit may be studied by a variety of morphological techniques which enable improved structure-function analyses. Two-dimensional light and electron microscopic sectioning techniques with and without specific markers are complemented by 3D vascularisation and perfusion study techniques. Static ex vivo modalities still prevail, however, the future will be dominated by intravital high-resolution techniques.
Residential greenness-related DNA methylation changes
2021
Abstract Background Residential greenness has been associated with health benefits, but its biological mechanism is largely unknown. Investigation of greenness-related DNA methylation profiles can contribute to mechanistic understanding of the health benefits of residential greenness. Objective To identify DNA methylation profiles associated with greenness in the immediate surroundings of the residence. Methods We analyzed genome-wide DNA methylation in 1938 blood samples (982 participants) from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). We estimated residential greenness based on normalized difference vegetation index at 30 × 30 m cell (green3…
Incidence of neuronal ceroid-lipofuscinoses in West Germany: Variation of a method for studying autosomal recessive disorders
1992
The incidence of neuronal ceroid-lipofuscinoses (NCL) in West Germany was determined using a novel method which is applicable to other autosomal recessively inherited diseases. Questionnaires were sent to all pediatric departments (answer rate 189/276, 68%), schools for the blind (39/46, 85%), and neuropathological institutes (15/22, 68%). Diagnoses were accepted only when based on firm clinical and/or electron microscopic criteria; 207 such identified patients were sorted according to year of birth. Plotting the cumulative number of new cases per year against the year of birth resulted in a slightly S-shaped curve. Before the year 1962, the curve is relatively flat, probably due to ineffic…
Swallowing evaluation with videofluoroscopy in the paediatric population
2017
Valutazione della funzione deglutitoria in videofluoroscopia nei pazienti pediatrici.I disturbi della deglutizione in età pediatrica possono essere dovuti a diverse cause, dalla condizione di prematurità e patologie malformative sino al reflusso gastro-esofageo o a patologie infettive od infiammatorie del primo tratto gastroenterico. Nei neonati il processo della deglutizione è involontario e basato su meccanismi riflessi. In seguito, nell’ infanzia, la fase orale diventa volontaria , mentre le fasi faringea ed esofagea rimangono involontarie. I disordini della deglutizione possono severamente compromettere le capacità respiratorie e l’apporto nutrizionale dei pazienti pediatrici. La videof…
Victimization at school: relationship of parenting and functional-dysfunctional developmental variables
2015
El presente estudio tiene como principal objetivo analizar elpapel diferencial de la crianza (apoyo y comunicación versus control), devariables funcionales del desarrollo (empatía y mecanismos de afrontamientofuncionales) y las variables disfuncionales (inestabilidad emocional yafrontamiento improductivo) en la victimización ocurrida en el entorno escolar,o por el contrario, con el apego entre pares. Participaron en el estudio418 alumnos, 224 chicas y 194 chicos adolescentes, entre 13 y 14 años,escolarizados en los niveles de 3º y 4º curso de Educación SecundariaObligatoria. Para analizar estas relaciones se llevó a cabo un modelo deecuaciones estructurales EQS. Los resultados obtenidos mue…
Illness perception, mood and coping strategies in allergic rhinitis: are there differences among ARIA classes of severity?
2014
Background: This study was designed to assess if illness perception, mood state and coping strategies differ according to allergic rhinitis (AR) persistence and severity. Methods: Illness perception, mood profiles, coping behaviors and rhinitis symptoms were assessed by means of validated tools inpatients classified according to the Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines. Results: Two hundred and thirty-one patients underwent data analysis. No difference in age, sex, socio-economic status, smoking habits was detected comparing patients according to AR severity, duration or 4 ARIA classes. Patients with intermittent AR reported higher scores than those with persistent A…
Über neue elektronenmikroskopische Befunde zur peripheren vegetativen Synapse am mesenterialen Lymphgefäss vom Meerschweinchen (Cavia porcellus)
1965
Electron microscopic investigations of innervation of the mesenteric lymphatic vessels ofCavia porcellus demonstrate that, besides membrane contacts between Axon and smooth muscle cell, a local direct plasmatic connection from the nature of synapses between the nerve and the effector cell have to be considered. From this study it has been concluded that also this neuromuscular junction is a transitoric structure and not a static connection comparable to the synapses in the motor end-plate of the striated muscle.