Search results for "COUNT"
showing 10 items of 5058 documents
Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells
2003
AbstractCoupling of ovalbumin (OVA) to anti–DEC-205 monoclonal antibody (mAb) (αDEC) induced the proliferation of OVA-specific T cells in vivo. Expansion was short-lived, caused by dendritic cells (DCs), and rendered T cells anergic thereafter. Phenotypic analysis revealed the induction of CD25+/CTLA-4+ T cells suppressing proliferation and interleukin-2 (IL-2) production of effector CD4+ T cells. The findings were supported by 2 disease models: (1) CD4+ T-cell–mediated hypersensitivity reactions were suppressed by the injection of αDEC-OVA and (2) the application of hapten-coupled αDEC-205 reduced CD8+ T-cell–mediated allergic reactions. Thus, targeting of antigens to immature DCs through …
Monitoring of anti-vaccine CD4 T cell frequencies in melanoma patients vaccinated with a MAGE-3 protein.
2005
Abstract Quantitative evaluation of T cell responses of patients receiving antitumoral vaccination with a protein is difficult because of the large number of possible HLA-peptide combinations that could be targeted by the response. To evaluate the responses of patients vaccinated with protein MAGE-3, we have developed an approach that involves overnight stimulation of blood T cells with autologous dendritic cells loaded with the protein, sorting by flow cytometry of the T cells that produce IFN-γ, cloning of these cells, and evaluation of the number of T cell clones that secrete IFN-γ upon stimulation with the Ag. An important criterion is that T cell clones must recognize not only stimulat…
Credit risk transmission in the European banking sector: the case of the subprime and Eurozone debt crises
2014
El objetivo del presente trabajo es analizar en profundidad la transmisión del riesgo de crédito, aproximado por los CDS spreads, en el sector bancario europeo durante el periodo 2006-2012, intentando dar respuesta a diversas cuestiones: (i) ¿existe evidencia de transmisión del riesgo de crédito entre las entidades financieras europeas de la Eurozona y las que no pertenecen a dicha zona?, (ii) ¿es esta transmisión bidireccional o unidireccional?, (iii) concretamente, ¿qué países han liderado dicha transmisión?, y (iv) ¿cómo se ha visto afectada dicha transmisión con las recientes crisis financieras? Los resultados indican un cambio significativo en la transmisión del riesgo de crédito con e…
Volatility spillovers in the European bank CDS market
2015
From the 2007 subprime crisis to the recent Eurozone debt crisis,the banking industry has experienced terrible financial instabilitywith increasing volatility levels of bank default probability. UsingEuropean CDS spreads data from January 2006 to March 2013, thispaper sheds light on the impact of three recent significant events ofcredit risk volatility transmission between, firstly, Eurozone andnon-Eurozone banks, and then between distressed peripheral andcore countries inside the Eurozone. We employ an asymmetricmultivariate BEKK model to measure cross-market volatility spil-lovers. We find that both recent crises are distinct episodes. Theglobal financial crisis that originated outside Eu…
Tirdzniecības atvērtības ietekme uz ekonomikas izaugsmi, CAE valstu empīriskais pētījums
2021
Darba mērķis ir izpētīt tirdzniecības atvērtības ietekmi uz ekonomikas izaugsmi, izmantojot 16 Centrālās un Austrumeiropas valstu paneļa datus 2010. – 2019. gadā, salīdzinot 4 dažādus tirdzniecības atvērtības rādītājus. Apvienotie OLS un fiksētie efekti tiek izmantoti kā primārie novērtētāji, un noturības analīzei tiek izmantots sistēmas GMM tests. Apkopoto OLS un fiksēto šķērsgriezumu regresiju iegūtie rezultāti parāda, ka dažādos tirdzniecības atvērtības mērījumos tirdzniecības atvērtība pozitīvi un ļoti nozīmīgi ietekmē ekonomikas izaugsmi. GMM sistēmas testi parāda tirdzniecības atvērtības negatīvo ietekmi uz ekonomikas izaugsmi, bet nozīmīgumu ieguva tikai divi atvērtības rādītāji.
Perspectives for CNO neutrino detection in Borexino
2018
International audience; Borexino measured with unprecedented accuracy the fluxes of solar neutrinos emitted at all the steps of the pp fusion chain. Still missing is the measurement of the flux of neutrinos produced in the CNO cycle. A positive measurement of the CNO neutrino flux is of fundamental importance for understanding the evolution of stars and addressing the unresolved controversy on the solar abundances. The measurement of the CNO neutrino flux in Borexino is challenging because of the low intensity of this component (CNO cycle accounts for about 1% of the energy emitted by Sun), the lack of prominent spectral features and the presence of background sources. The main background c…
“Judicial Independence vs. Judicial Accountability. Judicial Selection Models for Constitutional Courts. A comparative analysis”
2012
Abstract La cronaca politica degli ultimi anni riporta un numero rilevante di confronti, dal tono più o meno conflittuale, tra le istituzioni politiche e quelle giurisdizionali. Di particolare rilevanza è che tale sorta di opposizione tra giustizia e politica coinvolga non solo l’operato delle magistrature ordinarie ma anche quello delle Corti costituzionali: le supreme garanti e guardiane di quei principi sui quali dovrebbe fondarsi l’intero ordinamento. A dispetto di ciò, esistono importanti occasioni in cui le autorità politiche e quelle giurisdizionali intrecciano i loro interessi, ed una di queste è proprio il momento in cui vengono reclutati i giudici costituzionali. Tuttavia, se…
Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study
2015
Globally, there is substantial concern regarding the challenges of treating complex drug resistance patterns in multidrug resistant tuberculosis cases. Utilising data from three different settings (Estonia, Latvia, Romania) we sought to contrast drug susceptibility profiles for multidrug resistant tuberculosis cases, highlight the difficulties in designing universal regimen, and inform future regimen selection. Demographic and microbiological surveillance data for multidrug resistant tuberculosis cases from 2004-13 were analysed. High levels of additional resistance to currently recommended second line drugs were seen in all settings, with extensive variability between countries. Accurate d…
Epidemiology and surveillance of human (neuro)cysticercosis in Europe: is enhanced surveillance required?
2020
To report on relevant national surveillance systems of (N)CC and taeniasis (the infection with the adult tapeworm) in the European Union/European Economic Area and to assess the magnitude of (N)CC occurrence by retrieving information on cases for the period 2000-2016.(N)CC cases were retrieved via national reporting systems, a systematic literature search, contact with clinicians and a search for relevant 'International Statistical Classification of Diseases and Related Health Problems' (ICD)-based data.Mandatory notification systems for (N)CC were found in Hungary, Iceland and Poland. Ten cases were reported in Poland and none in Hungary and Iceland. Through the systematic literature revie…
Lipid-lowering therapy use in primary and secondary care in Central and Eastern Europe: DA VINCI observational study.
2021
Abstract Background and aims Central and Eastern Europe (CEE) is a largely understudied region, despite having the highest cardiovascular disease mortality in Europe. This analysis aimed to assess the proportion of patients in CEE who achieved their LDL-C goals based on individual cardiovascular risk recommended by the 2016 and 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines. Methods The DA VINCI study was a cross-sectional observational study of primary and secondary prevention patients receiving lipid-lowering therapy across Europe between June 2017 and November 2018. Results In total, 2154 patients were enrolled from the Czech Republic (n = 509…