Search results for "CPB"

Successful aerobic bioremediation of groundwater contaminated with higher chlorinated phenols by indigenous degrader bacteria

2018

The xenobiotic priority pollutant pentachlorophenol has been used as a timber preservative in a polychlorophenol bulk synthesis product containing also tetrachlorophenol and trichlorophenol. Highly soluble chlorophenol salts have leaked into groundwater, causing severe contamination of large aquifers. Natural attenuation of higher-chlorinated phenols (HCPs: pentachlorophenol + tetrachlorophenol) at historically polluted sites has been inefficient, but a 4-year full scale in situ biostimulation of a chlorophenol-contaminated aquifer by circulation and re-infiltration of aerated groundwater was remarkably successful: pentachlorophenol decreased from 400 μg L−1 to <1 μg L−1 and tetrachlorophen…

Tokamak cooling systems and power conversion system options

2022

DEMO will be a fusion power plant demonstrating the integration into the grid architecture of an electric utility grid. The design of the power conversion chain is of particular importance, as it must adequately account for the specifics of nuclear fusion on the generation side and ensure compatibility with the electric utility grid at all times. One of the special challenges the foreseen pulsed operation, which affects the operation of the entire heat transport chain. This requires a time-dependant analysis of different concept design approaches to ensure proof of reliable operation and efficiency to obtain nuclear licensing. Several architectures of Balance of Plant were conceived and dev…

Progress in the design development of EU DEMO helium-cooled pebble bed primary heat transfer system

2019

Abstract In the frame of the activities promoted and encouraged by the EURO-fusion Power Plant Physics and Technology (PPPT) department aimed at developing the EU-DEMO fusion reactor, strong emphasis has been recently posed to the whole Balance of Plant (BoP) which represents the set of systems devoted to convert the plasma generated thermal power into electricity and to deliver it to the grid. Among these systems, a very important role is played by the Breeding Blanket (BB) Primary Heat Transfer System (PHTS) as it is responsible to extract more than 80% of the fusion plasma power. In this framework, University of Palermo, Ansaldo Nucleare and CREATE have focused their work to improve ther…

Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis

2018

Abstract: Chemotherapy is currently the only effective approach to treat all forms of leishmaniasis. However, its effectiveness is severely limited due to high toxicity, long treatment length, drug resistance, or inadequate mode of administration. As a consequence, there is a need to identify new molecular scaffolds and targets as potential therapeutics for the treatment of this disease. We report a small series of 1,2‐substituted‐1H‐benzo[d]imidazole derivatives (9ad) showing affinity in the submicromolar range (Ki = 0.150.69 μM) toward Leishmania mexicanaCPB2.8ΔCTE, one of the more promising targets for antileishmanial drug design. The compounds confirmed activity in vitro against intrace…

Pre-conceptual design of EU DEMO balance of plant systems: Objectives and challenges

2021

Abstract The European Research Roadmap to the Realisation of Fusion Energy foresees that the DEMO reactor is going to succeed ITER in the pathway towards the exploitation of nuclear fusion, achieving long plasma operation time, demonstrating tritium self-sufficiency and producing net electric output on an industrial scale. Therefore, its design must be more oriented towards the Balance of Plant (BoP) than it is in ITER. Since the early pre-conceptual phase of the DEMO project, emphasis has been laid on identifying the main requirements affecting the overall architecture of the BoP. For instance, specific efforts and proper solutions have been envisaged to cope with the pulsed nature of the …

Preliminary design of EU DEMO helium-cooled breeding blanket primary heat transfer system

2018

Abstract The European DEMO conceptual design foresees four Breeding Blanket (BB) concepts that rely on different cooling and breeding technologies. As DEMO has been conceived to deliver net electricity to the grid, the choice of the blanket coolant plays a pivotal role in the reactor design having a strong influence on plant operation, safety and maintenance. Moreover, the machine pulsed operation makes the BB Primary Heat Transfer System (PHTS) the main hub of the DEMO Balance of Plant (BoP). Within this framework, a study has been carried out to design the Ex-Vessel PHTS of the Helium-Cooled Pebble Bed (HCPB) BB concept. The paper describes criteria and rationale followed with the aim to …

Design and development of hyaluronan-functionalized polybenzofulvene nanoparticles as CD44 receptor mediated drug delivery system

2017

A tri-component polymer brush (TCPB), composed of a polybenzofulvene copolymer bearing low molecular weight hyaluronic acid (HA) on the surface of its cylindrical brush-like backbone and oligo-PEG fractions, was employed in the preparation of 350 nm nanostructured drug delivery systems capable of delivering the anticancer drug doxorubicin. The obtained drug delivery systems were characterized on the basis of drug loading and release, dimensions and zeta potential, morphology and in vitro cell activity, and uptake on three different human cell lines, namely the bronchial epithelial 16HBE, the breast adenocarcinoma MCF-7, and the colon cancer HCT116 cells. Finally, the ability of doxorubicin…

Thermo-mechanical experiment and analysis on an HCPB-TBM mock-up

2008

A constitutive model for the thermo-mechanical behaviour of fusion-relevant pebble beds and its application to the simulation of HELICA mock-up exper…

2007

Abstract Within the framework of the R&D activities promoted by EFDA on the Helium-Cooled Pebble Bed Test Blanket Module to be irradiated in ITER, attention has been focused on the modelling of the thermo-mechanical behaviour of both beryllium and lithiated ceramic pebble beds that are envisaged to be used respectively as neutron multiplier and tritium breeder. This behaviour depends, mainly, on the reactor-relevant conditions, the pebble sizes and the breeder cell geometries and a general constitutive model has not yet been validated, especially for fusion-relevant applications. ENEA-Brasimone and the Department of Nuclear Engineering (DIN) of the University of Palermo have performed inten…

What Is the Role of Minimally Invasive Mitral Valve Surgery in High-Risk Patients? A Meta-Analysis of Observational Studies

2016

Background. Minimally invasive valve surgery is related to certain better postoperative outcomes. We aimed to assess the role of minimally invasive mitral valve surgery in high-risk patients. Methods. A systematic literature review identified eight studies of which seven fulfilled criteria for metaanalysis. Outcomes for a total of 1,254 patients (731 were conventional standard sternotomy and 523 were minimally invasive mitral valve surgery) were submitted to meta-analysis using random effects modeling. Heterogeneity and subgroup analysis with quality scoring were assessed. The primary end point was early mortality. Secondary end points were intraoperative and postoperative outcomes and long…