Search results for "CQ"
showing 10 items of 1801 documents
Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space
2019
Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different individuals remain poorly understood. To quantitatively describe epitope immunogenicity, here we propose a supervised machine learning framework generating probabilistic estimates of immunogenicity, termed "immunogenicity scores," based on the numerical features computed through sequence-based simulation approximating the molecular scanning process of peptides presented onto major histocompatibility complex (MHC) by the human T cell receptor (T…
γδ T Cells Cross-Link Innate and Adaptive Immunity in Mycobacterium tuberculosis Infection
2011
Protective immunity against mycobacterial infections such asMycobacterium tuberculosisis mediated by interactions between specific T cells and activated antigen presenting cells. To date, many aspects of mycobacterial immunity have shown that innate cells could be the key elements that substantially may influence the subsequent adaptive host response. During the early phases of infection, innate lymphocyte subsets play a pivotal role in this context. Here we summarize the findings of recent investigations onγδT lymphocytes and their role in tuberculosis immunity.
Investigating the professional agency of secondary school English teachers in South Korea
2020
This qualitative study examines the professional agency of secondary English teachers in Midwestern South Korea. Specifically, it investigates how secondary English teachers in South Korea understand their professional agency and what mediates their professional agency. The ecological approach in this study recognises that agency encompasses both individual and environmental dimensions and is formed through the constant interplay between the individual and the environment. The dataset for this study comprises 15 semi-structured interviews with secondary English teachers in South Korea. The thematic analysis highlights a significant gap between Korean English teachers’ espoused agency and re…
Multimodalidad e innovación metodológica en la enseñanza del inglés: el álbum ilustrado como recurso literario y visual para el desarrollo del conoci…
2020
Este artículo se centra en el proyecto de innovación 'Recursos multimodales y literacidad' (UV-SFPIE_GER18-952026) llevado a cabo en la Facultat de Magisteri de la Universitat de València durante los cursos 2017-18 y 2018-19. En consonancia con los retos de la sociedad digital del siglo XXI y con el enfoque de la pedagogía de las multiliteracidades para el desarrollo del conocimiento, proponemos la multimodalidad, y en especial, el álbum ilustrado, primero, como un recurso literario y estético clave para la formación integral de los futuros docentes de inglés como L2 y, segundo, como una plataforma interdisciplinar para la construcción de significados. Los resultados de la investigación cua…
The Use of Digital Storytelling for ESP in a Technical English Course for Aerospace Engineers.
2012
Digital Storytelling is a powerful pedagogical tool for both students and educators, which started to be used for teaching and learning purposes a few years ago, becoming more and more popular over time. The use of digital storytelling in non-specific language learning contexts has been widely explored, as shown in the literature. However, its use in technical-scientific contexts of English for Specific Purposes (ESP) has not been so widely studied. This paper explores a project of digital storytelling for ESP carried out at the Universitat Politècnica de València, in Spain. The methodology was divided into several stages: completing a pre- and a post-survey, learning about digital storytel…
Emerging Constructions in the L2 Italian Spoken by Low Literate Migrants
2019
The emergence of autonomous interlanguage constructions is widely recognised in the literature on L2 Italian. These constructions involve the overgeneralisation of functional forms learners are in the process of acquiring, e.g., siamo in siamo mangiare &lsquo
La representació conceptual del gènere. Una revisió crítica
2013
Des de la perspectiva psicolingüística, diversos treballs s’han preguntat si el gènere es representa a nivell conceptual. En el marc de les noves interpretacions de la hipòtesi del relativisme lingüístic, s’ha proposat que les diferències de gènere (masculí o femení) influencien la conceptualització. Aquest article fa una anàlisi d’alguns dels estudis de referència i argumenta que a partir d’aquests estudis no es pot concloure que el gènere tingui efectes en el pensament no lingüístic. La revisió feta indica que el gènere és una propietat lexicosemàntica dels noms i que es representa lingüísticament, la qual cosa és compatible amb la hipòtesi del Pensar per Parlar. Tanmateix, es defensa que…
L'adquisició infantil de les llengües de signes
2003
[ENG] This article offers an overview of research in sign language acquisition by children, mostly in American Sign Language. The results indicate that the developmental milestones and the linguistic errors made by children acquiring a sign language coincide with those observed in hearing children acquiring spoken languages. The visual-gestural modality is shown not to have the expected impact on the acquisition processes, which is arguably regulated by strictly linguistic principles.
Testing audiovisual comprehension tasks with questions embedded in videos as subtitles: a pilot multimethod study
2017
<p>Listening, watching, reading and writing simultaneously in a foreign language is very complex. This paper is part of wider research which explores the use of audiovisual comprehension questions imprinted in the video image in the form of subtitles and synchronized with the relevant fragments for the purpose of language learning and testing. Compared to viewings where the comprehension activity is available only on paper, this innovative methodology may provide some benefits. Among them, it could reduce the conflict in visual attention between watching the video and completing the task, by spatially and temporally approximating the questions and the relevant fragments. The technique…
Exponentiating derivations of quasi∗-algebras: possible approaches and applications
2005
The problem of exponentiating derivations of quasi∗-algebras is considered in view of applying it to the determination of the time evolution of a physical system. The particular case where observables constitute a properCQ∗-algebra is analyzed.