Search results for "CQ"
showing 10 items of 1801 documents
Biomarkers in Community-Acquired Pneumonia (Cardiac and Non-Cardiac)
2020
Community-acquired pneumonia (CAP) remains the first cause of morbidity and mortality worldwide due to infection. Several aspects such as severity and host response are related to its clinical course and outcome. Beyond the acute implications that the infection provokes in the host, pneumonia also has long-term negative consequences. Among them, cardiovascular complications and mortality are the most outstanding. Therefore, an adequate recognition and stratification of the risk of complications and mortality is crucial. Many biomarkers have been studied for these reasons, considering that each biomarker mirrors a different aspect. Moreover, the clinical application of many of them is still …
The immune response behavior in HIV-AIDS patients treated with ozone therapy for two years
2018
HIV continues to be one of the biggest problems for the global public health. The African region is one of the most affected, accounting for almost two thirds of the new infections. Many of them are retroviral medications and multi-therapies aiming to stop the viral replication and maintaining immunological stability, which fail to guarantee the quality of life or enhance the patient's immunity
 Ozone has biological properties, among which the antimicrobial and modulatory effect on the immune response is highlighted, which makes it possible to use it in a complementary way for the treatment of these patients.
 We conducted the present study in which the effect of the ozone therapy…
Kontrastmittelverstärkte 3D-MRA der Pulmonalarterien mit integrierter paralleler Akquisitionstechnik (iPAT) bei Patienten mit CTEPH - sagittale oder …
2004
PURPOSE Comparison of two different types of contrast-enhanced 3D-MR angiography (CE-MRA) with integrated parallel acquisition technique (iPAT) in patients with chronic-thromboembolic pulmonary hypertension (CTEPH) and evaluation whether sagittal acquisition with higher resolution and minimized acquisition time is superior to common coronal orientation. MATERIALS AND METHODS CE-MRA was performed on 15 patients with CTEPH preoperatively and on 10 patients also postoperatively, while 5 other patients received only a postoperative MRA. All 30 MR studies with one coronal and two sagittal acquisitions were blindly evaluated and compared. The resolution of coronal and sagittal MRA was 1.3 x 0.6 x…
Repetition without Repetition or Differential Learning of Multiple Techniques in Volleyball?
2021
A variety of approaches have been proposed for teaching several volleyball techniques to beginners, ranging from general ball familiarization to model-oriented repetition to highly variable learning. This study compared the effects of acquiring three volleyball techniques in parallel with three approaches. Female secondary school students (N = 42
Dynamics of gut mucosal and systemic Th1/Th2 cytokine responses in interferon-gamma and interleukin-12p40 knock out mice during primary and challenge…
2009
Cryptosporidium parvum is an intracellular parasite causing enteritis which can become life-threatening in the immunocompromised host. CD4+ T cells and interferon (IFN)-gamma play dominant roles in host immune response to infection. However, effector mechanisms that are responsible for recovery from infection are poorly understood. In the present study we analyzed mice deficient in IFN-gamma or interleukin (IL)-12 in parallel to C57BL/6 wild type mice as models for murine cryptosporidiosis. Our results identified IFN-gamma as the key cytokine in the innate as well as adaptive immunity during primary and also challenge C. parvum infection. Furthermore, both Th1 and Th2 cytokines appear to co…
Immune Modulating Effects of NKT Cells in a Physiologically Low Dose Leishmania major Infection Model after αGalCer Analog PBS57 Stimulation
2014
Leishmaniasis is a parasitic infection affecting ∼12 million people worldwide, mostly in developing countries. Treatment options are limited and no effective vaccines exist to date. Natural Killer T (NKT) cells are a conserved innate-like lymphocyte population with immunomodulating effects in various settings. A number of reports state a role of NKT cells in different models of Leishmania infection. Here, we investigated the effect of NKT cells in a physiologically relevant, intradermal low dose infection model. After inoculation of 103 infectious-stage L. major, comparable numbers of skin-immigrating NKT cells in both susceptible BALB/c mice and resistant C57BL/6 mice were noted. Compared …
Harnessing dendritic cells in cancer.
2011
Dendritic cells (DCs) are central to the initiation of tumor-specific immune responses. However, the tumor microenvironment generates immunosuppressive cells and soluble mediators that compromise DC functions and limit the success of DC-based therapies. Progress in understanding DC metabolism in cancer is uncovering novel therapeutic targets that could restore DC capacity to prime T cells and trigger effective anticancer responses. Accumulating evidence also indicates that conventional chemo- and radiotherapy protocols can cause DC activation, enhance antigen cross-presentation, selectively eliminate immunosuppressive cells and revert the immunosuppression state caused by cancer, suggesting…
I testi dell'analogia: introduzione alla prima edizione americana de L'architettura della città
2012
La tradizione dell’architetto-scrittore ha molti precedenti nella storia dell’architettura italiana. Dal Rinascimento all’Ottocento era caratteristica di certi architetti il presentare le loro idee in forma di trattati sistematici. Sul modello di Vitruvio, Alberti produsse il modello rinascimentale per tale tipo di scrittura. Fu seguito dalla trattatistica di Serlio e Palladio. Serlio compose una serie di volumi che costituirono veri e propri manuali per l’architettura, iniziando dall’edificio antico sino ad arrivare a riflessioni su lavori futuri non ancora realizzati. La rilevanza di tali progetti non costruiti, destinati a diventare più importanti dei modesti progetti effettivamente real…
External knowledge sourcing for R&D activities: antecedents and implications of governance mode choice
2014
This paper investigates how internal and external factors affect the choice between alliances and joint ventures (A&JVs) and mergers and acquisitions (M&As) for the external sourcing of research and development (R&D) activities, and whether or not such a choice is really con- tingent, that is, is it the best choice in terms of its impact on firms’ innovative performance under those circumstances? We build a set of hypotheses based on both the transaction-cost theory and the resource-based view, and test them through a secondary data source analy- sis. We found that companies adopt either R&D M&A or A&JV depending on internal (e.g. resources and capabilities, innovation experience) and exter…
Adapter stabilizujący do długich preparatów mikroskopowych – budowa i zastosowanie w cyfrowym pozyskiwaniu obrazu
2018
Możliwość wykonywania, za pomocą mikrotomu typu „core--microtome”,preparatów z całych wywiertów wygenerowała problem związany ze stabilizacją preparatów podczas procesu pozyskiwania i zapis ich obrazu. Zaproponowane ostatnio dwa adaptery do długich preparatów mikroskopowych rozwiązały problem ich stabilizacji oraz umożliwiły kontrolę pozycji docelowych fragmentów w polu widzenia obiektywu. Konstrukcje te nie rozwiązują wszystkich potrzeb pojawiających się podczas pozyskiwania obrazu na potrzeby ilościowej anatomii drewna. W artykule proponujemy udoskonaloną wersję adaptera do długich preparatów mikroskopowych wychodzącą naprzeciw potrzebom użytkowników wcześniejszych wersji. Konstrukcje te …