Search results for "CQ"
showing 10 items of 1801 documents
A way to screen for suffering in palliative care
1997
We report a new tool for screening the suffering of terminally ill patients in a palliative care service. We systematically asked 371 terminal oncological and AIDS patients on 665 different occasions, “How long did yesterday seem to you?”; we then asked them to assess their current condition. The simple answer about subjective length of time correlated well with subjective suffering in approximately half the patients. Thus it may be a good starting point for future assessment and more extensive explorations.
NUTRITION AND CANCER
1969
The last decades have seen the identification of a number of drugs targeting oncogene pathways, therefore contributing to moving the cancer therapy field toward precision medicine. However, existing and acquired resistance to targeted therapies represent major obstacles against their long-term effectiveness. In fact, the initial efficacy of targeted therapies is often limited to a portion of the patient population and is frequently followed by the acquisition of drug-resistant disease.
L’acqua tra natura e artificio nella cultura del giardino europeo dei secoli XVIII e XIX, dal Landscape garden al Picturesque garden
2010
L’acqua, protagonista del giardino sin dalle sue origini, nella storia del giardino e del paesaggio, ha da sempre rivestito un ruolo fondamentale sia per il suo valore scenografico che per il suo valore altamente simbolico. A partire dalla prima metà del XVIII, con il tramontare del giardino formale, cui si sostituisce il giardino paesistico di origine anglosassone, l’acqua resta una componente fondamentale all’interno della progettazione dei giardini, ma assume un ruolo diverso: messe al bando le forme regolari e le rigide simmetrie, con la nascita del giardino paesistico l’acqua è «disegnata» in forme libere e, trasformandosi in lago o stagno, sembra voler riacquistare la sua forma origin…
Increased ventilation by fish leads to a higher risk of parasitism
2014
Background: Fish are common intermediate hosts of trematode cercariae and their gills can potentially serve as important sites of penetration by these larval stages. We experimentally tested the hypothesis that volume of ventilation flow across the gills contributes to acquisition of these parasites by fish. We manipulated the intensity of ventilation by using different oxygen concentrations. Methods: Juvenile Oncorhynchus mykiss were individually exposed for 10 minutes to a standard dose of Diplostomum pseudospathaceum cercariae at three levels of oxygen concentration, 30, 60 and 90%. Ventilation amplitude (measured as a distance between left and right operculum), operculum beat rate, and …
Gillis van Coninxloo, in G. C. SCIOLLA (a cura di), Cielo terra e acque: il paesaggio nella pittura fiamminga e olandese tra Cinquecento e Seicento, …
2006
Gillis van Coninxloo, in G. C. SCIOLLA (a cura di), Cielo terra e acque: il paesaggio nella pittura fiamminga e olandese tra Cinquecento e Seicento, Torino, Elede, 2006 p. 35-133
Early steps in the European eel (Anguilla anguilla)–Vibrio vulnificus interaction in the gills: Role of the RtxA13 toxin
2015
Vibrio vulnificus is an aquatic gram-negative bacterium that causes a systemic disease in eels called warm-water vibriosis. Natural disease occurs via water born infection; bacteria attach to the gills (the main portal of entry) and spread to the internal organs through the bloodstream, provoking host death by haemorrhagic septicaemia. V.vulnificus produces a toxin called RtxA13 that hypothetically interferes with the eel immune system facilitating bacterial invasion and subsequent death by septic shock. The aim of this work was to study the early steps of warm-water vibriosis by analysing the expression of three marker mRNA transcripts related to pathogen recognition (tlr2 and tlr5) and in…
Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4
2012
Ingestion of wheat, barley, or rye triggers small intestinal inflammation in patients with celiac disease. Specifically, the storage proteins of these cereals (gluten) elicit an adaptive Th1-mediated immune response in individuals carrying HLA-DQ2 or HLA-DQ8 as major genetic predisposition. This well-defined role of adaptive immunity contrasts with an ill-defined component of innate immunity in celiac disease. We identify the α-amylase/trypsin inhibitors (ATIs) CM3 and 0.19, pest resistance molecules in wheat, as strong activators of innate immune responses in monocytes, macrophages, and dendritic cells. ATIs engage the TLR4–MD2–CD14 complex and lead to up-regulation of maturation markers a…
Foreign Investment, Strategic Assets and National Security (Table of Contents)
2018
At the time of a paradigm change Foreign Investment, Strategic Assets and National Security is a timely analysis of the changing attitude towards foreign investment in major economies, namely the United States of America, the People’s Republic of China, Australia, Canada, and Germany, France and the United Kingdom as representatives of the European Union. Foreign investment has grown steadily for decades and the de-regulation of international trade and investment was a widely accepted trend, particularly in developed countries. Increasingly, however, this development is encountered by opposition. Globalisation and socio-economic effects of mergers and acquisitions of domestic firms by forei…
Designing and Evaluating Online Language Learning Materials for Higher Education
2011
Nowadays, finding, choosing and developing or adapting materials is a very important component of education as well as a key element for the success of the whole learning process. A language teacher is also a materials developer and the materials development process should aim at ensuring that local needs and wants do not dictate decisions and that important learning principles are not forgotten. In the case of materials for Computer-Assisted Language Learning (CALL), a very thorough and pedagogically-sound set of guidelines should be followed prior to the design of the materials. Following that, a careful evaluation should take place so as to guarantee that those guidelines have been follo…
PEMBELAJARAN BAHASA BERBASIS LINGKUNGAN SEBAGAI UPAYA MEMBANGUN KECERDASAN EKOLOGIS
2018
The paper gives a conditional understanding about the importance of environmental-based learning to establish ecological intelligence. Environmental-based anguage learning is an effort to increase knowledge and understanding aiming at giving critical understanding to the community learners in order to build ecological intelligence for human sake.Environmental preservation effort through the texts in language learning representatively gives a picture of how rich human knowledge about the nature is. Thus, it is worth that through formal and non-formal education which are the basis for intellectual community, environmental-based learning is integrated in language learning. This is reasonable s…