Search results for "CQ"

Anti-inflammatory Therapies for Cardiovascular Disease: Signaling Pathways and Mechanisms

2019

Cardiovascular diseases (CVD) are the clinical manifestation of atherosclerosis, a chronic inflammatory disease promoted by several risk factors such as dyslipidemia, type 2 diabetes mellitus, hypertension, and smoking. Acute CVD events are the result of an unresolved inflammatory chronic state that promotes the rupture of unstable plaque lesions. Of note, the existing intensive therapies modify risk factors but do not prevent life-threatening recurrent ischemic events in high-risk patients, who have a residual inflammatory risk displayed by increased C-reactive protein (CRP) levels. Better understanding of the role of innate and adaptive immunity in plaque development and rupture has led t…

Augmenting the algorithm: emerging human-in-the-loop work configurations

2020

Abstract How do configurations of humans and algorithms evolve as firms adopt artificial intelligence (AI) capabilities, and what are the implications for work and organization? We explored these questions through a two-year long case study of an organization in the international maritime trade that introduced automated algorithmic support for data analysis and prediction work. Drawing on a human–machine configuration perspective, we found that humans and the algorithm were configured and reconfigured in multiple ways over time as the organization dealt with the introduction of algorithmic analysis. In contrast to replacing human work, the emergent configurations required new roles and redi…

A practical framework for data management processes and their evaluation in population-based medical registries.

2013

We present a framework for data management processes in population-based medical registries. Existing guidelines lack the concreteness we deem necessary for them to be of practical use, especially concerning the establishment of new registries. Therefore, we propose adjustments and concretisations with regard to data quality, data privacy, data security and registry purposes.First, we separately elaborate on the issues to be included into the framework and present proposals for their improvements. Thereafter, we provide a framework for medical registries based on quasi-standard-operation procedures.The main result is a concise and scientifically based framework that tries to be both broad a…

Content Code Blurring: A New Approach to Content Extraction

2008

Most HTML documents on the world wide web contain far more than the article or text which forms their main content. Navigation menus, functional and design elements or commercial banners are typical examples of additional contents. Content extraction is the process of identifying the main content and/or removing the additional contents. We introduce content code blurring, a novel content extraction algorithm. As the main text content is typically a long, homogeneously formatted region in a web document, the aim is to identify exactly these regions in an iterative process. Comparing its performance with existing content extraction solutions we show thatfor most documents content code blurrin…

Expression and function of micro-RNAs in immune cells during normal or disease state.

2008

Micro-RNAs (miRNAs) are 19-24 nucleotide long non-coding RNAs that posttranscriptionally modulate gene expression. They are found in almost all species: viruses, plants, nematodes, fly, fish, mouse, human, and are implicated in a wide array of cellular and developmental processes. Microarray-based miRNA profiling brought to the discovery of miRNAs specific to different hematopoietic lineages. Furthermore, the functional assays performed in tissue cultures to discover miRNAs involved in immune responses in combination with the reports of miRNA-transgenic or miRNA -knockout mouse models has helped elucidating the miRNA roles in the development and function of immune system. Abnormal patterns …

Changes in CD4+ cells’ miRNA expression following exposure to HIV-1

2010

Background: Micro RNAs (miRNAs) inhibit HIV-1 expression by either modulating host innate immunity or by directly interfering with viral mRNAs. Here, we investigated the miRNA profile that discriminates different classes of HIV-1-infected patients from multiple-exposed uninfected individuals. Methods: The expression levels of 377 miRNAs were selectively analysed in CD4+ cells isolated from whole blood of HIV-1 elite LTNP (eLTNP), naive, and multiply exposed uninfected individuals (MEUs). MiRNA extraction was performed by the mir Vana™ miRNA Isolation Kit (Ambion), and their expression was subsequently examined by real-time PCR-based arrays. The expression of miRNAs was also determined in pr…

Network of Cells and Mediators of Innate and Adaptive Cutaneous Immunity

2017

The skin is a major surface organ that translates external signals from the environment into local and systemic immune responses. As such, it is also strongly involved in fighting against cutaneous pathogens transmitted by arthropod vectors to the host. By harboring various skin-resident as well as highly motile immune cells and unique molecules, the skin orchestrates resulting immune responses against pathogens. Only an understanding of the complexity of skin immunity will lead to a better assessment of vector-induced alterations of resulting antipathogen immunity.

The Fundamentals of T‐cell Lymphocyte Biology

2021

Human GITR Ligand Is Expressed on Tumor Cells and Reduces Cytokine Production and Cellular Cytotoxicity of NK Cells Identified to Express GITR.

2005

Abstract Members of the tumor necrosis factor (TNF) superfamily mediate multiple cellular functions including cellular proliferation, differentiation, and cell death. Human Glucocorticoid-induced TNF Receptor (GITR) has been shown to be expressed on T cells, is upregulated following activation and mediates costimulatory signals. The human GITR ligand (GITRL) has been reported to be expressed on antigen presenting cells and various healthy nonlymphoid tissues including small intestine, ovary, testis, kidney and endothelial cells. We analyzed multiple tumor cell lines of hematopoietic and epithelial origin as well as of germ cell lineage and various gliomas by RT-PCR and FACS analysis. Both G…

Microgravity-induced alterations in signal transduction in cells of the immune system

2010

Since decades it is known that the activity of cells of the immune system is severely dysregulated in microgravity, however, the underlying molecular aspects have not been elucidated yet. The identification of gravity-sensitive molecular mechanisms in cells of the immune system is an important and indispensable prerequisite for the development of counteractive measures to prevent or treat disturbed immune cell function of astronauts during long-term space missions. Moreover, their sensitivity to altered gravity renders immune cells an ideal model system to understand if and how gravity on Earth is required for normal mammalian cell function and signal transduction. We investigated the effec…