Search results for "CREATINE"
showing 10 items of 213 documents
Mood profile of an America's Cup team: relationship with muscle damage and injuries.
2010
Purpose: To describe the mood profile of an America’s Cup sailing team during competition and to evaluate the influence of previous injuries occurrence and intensity of physical work on the boat upon mood state. Relationships between mood domains and metabolic markers of muscle damage were also investigated. Methods: A descriptive study was conducted on an America’s Cup yachting race crew comprising 21 male sailors (mean T SD; age = 27.6 T 8.5 yr, weight = 89.3 T 24.9 kg, BMI = 26.5 T 6.9 kgImj2). All measurements were collected during the Louis Vuitton Cup 2007 in Valencia, Spain. The POMS test and creatine kinase (CK) serum activity were measured and correlated. Sailors were grouped accor…
Recovery after Heavy Resistance Exercise and Skeletal Muscle Androgen Receptor and Insulin-Like Growth Factor-I Isoform Expression in Strength Traine…
2011
The effects of heavy resistance exercise on skeletal muscle androgen receptor (AR) protein concentration and mRNAs of AR, insulin-like growth factor-I (IGF)-IEa, and mechano growth factor (MGF) expression were examined from biopsies of vastus lateralis (VL) muscle before and 48 hours after heavy resistance exercise (5 × 10 repetition maximum [RM] leg press and 4 × 10RM squats) in 8 adult strength trained men. The present exercise induced an acute decrease in maximal isometric force and increased serum total testosterone (T) and free testosterone (FT) concentrations. During 2 recovery days, maximal isometric force and subjective perception of physical fitness remained significantly lowered, …
Muscle damage induced by stretch-shortening cycle exercise
1998
Strenuous stretch-shortening cycle exercise was used as a model to study the leakage of proteins from skeletal muscle.The analysis included serum levels of creatine kinase (S-CK), myoglobin (S-Mb), and carbonic anhydrase (S-CA III). Blood samples from power- (N=11) and endurance-trained (N=10) athletes were collected before, 0, and 2 h after the exercise, which consisted of a total of 400 jumps.The levels of all determined myocellular proteins increased immediately after the exercise (P0.05-0.001) among both subject groups. In the endurance group, the protein levels increased (P0.05-0.001) further during the following 2 h after the exercise, and the ratio of S-CA III and S-Mb decreased (P0.…
Acute and prolonged reduction in joint stiffness in humans after exhausting stretch-shortening cycle exercise.
2002
The purpose of the present study was to examine the acute and long-term fatigue effects of exhausting stretch-shortening cycle (SSC) exercise on the stiffness of ankle and knee joints. Five subjects were fatigued on a sledge apparatus by 100 maximal rebound jumps followed by continuous submaximal jumping until complete exhaustion. Neuromuscular fatigue ef- fects were examined in submaximal hopping (HOP) and in maximal drop jumps (DJ) from 35 (DJ35) and 55 cm (DJ55) heights on a force plate. Additional force and reflex measurements were made using an ankle ergom- eter. Jumping tests and ankle ergometer tests were car- ried out before, immediately after, 2 h (2H), 2 days and 7 days (7D) after…
Application of C1-Esterase Inhibitor During Reperfusion of Ischemic Myocardium
2001
Background—Complement activation during reperfusion of ischemic myocardium augments myocardial injury, and complement inhibition with C1-esterase inhibitor (C1-INH) at the time of reperfusion exerts marked cardioprotective effects in experimental studies. Application of C1-INH in newborns, however, was recently reported to have dangerous and even lethal side effects. This study addresses the essential role of dosage in studies using C1-INH.Methods and Results—Cardioprotection by C1-INH was examined in a pig model with 60 minutes of coronary occlusion followed by 120 minutes of reperfusion. C1-INH was administered intravenously 5 to 10 minutes before coronary reperfusion without heparin at a…
Efficacy and safety of bempedoic acid for the treatment of hypercholesterolemia: A systematic review and meta-analysis
2020
Background Bempedoic acid is a first-in-class lipid-lowering drug recommended by guidelines for the treatment of hypercholesterolemia. Our objective was to estimate its average effect on plasma lipids in humans and its safety profile. Methods and findings We carried out a systematic review and meta-analysis of phase II and III randomized controlled trials on bempedoic acid (PROSPERO: CRD42019129687). PubMed (Medline), Scopus, Google Scholar, and Web of Science databases were searched, with no language restriction, from inception to 5 August 2019. We included 10 RCTs (n = 3,788) comprising 26 arms (active arm [n = 2,460]; control arm [n = 1,328]). Effect sizes for changes in lipids and high-…
Protective action of 1,3-butanediol in cerebral ischemia. A neurologic, histologic, and metabolic study.
1987
1,3-Butanediol (BD) is converted in the body to β-hydroxybutyrate, and previous studies have shown that hyperketonemia had beneficial effects in experimental models of generalized hypoxia. The aim of this study was to determine if BD would reduce brain damage following cerebral ischemia. A transient forebrain ischemia of 30-min duration was induced by the four-vessel occlusion technique in control and BD-treated rats (25 mmol/kg, i.p.; 30 min prior to ischemia). BD treatment led to significant improvement of neurologic deficit during the 72-h recovery period and reduced neuronal damage in the striatum and cortex but not in the CA1 sector of the hippocampus. Evaluation of cerebral energy me…
Metabolomic analysis of long-term spontaneous exercise in mice suggests increased lipolysis and altered glucose metabolism when animals are at rest
2014
Exercise has been associated with several beneficial effects and is one of the major modulators of metabolism. The working muscle produces and releases substances during exercise that mediate the adaptation of the muscle but also improve the metabolic flexibility of the complete organism, leading to adjustable substrate utilization. Metabolomic studies on physical exercise are scarce and most of them have been focused on the effects of intense exercise in professional sportsmen. The aim of our study was to determine plasma metabolomic adaptations in mice after a long-term spontaneous exercise intervention study (18 mo). The metabolic changes induced by long-term spontaneous exercise were su…
SERUM CREATINE KINASE LEVEL IN AMYOTROPHIC LATERAL SCLEROSIS: A USEFUL DIAGNOSTIC AID?
2008
...
Heterogeneous response to differentiation induction with different polar compounds in a clonal rat rhabdomyosarcoma cell line (BA-HAN-1C)
1989
The clonal rat rhabdomyosarcoma cell line BA-HAN-1C was tested for its susceptibility to differentiation induction with different polar compounds. This cell line is composed of proliferating mononuclear tumour cells, some of which spontaneously fuse to form terminally differentiated postmitotic myotube-like giant cells. Exposure of BA-HAN-1C cells to dimethylsulphoxide (DMSO), hexamethylene bisacetamide (HMBA), sodium butyrate (NaBut) and N-monomethylformamide (NMF) resulted in a significant inhibition of proliferation (P less than 0.001) and in a simultaneous increase in differentiation. The response was most pronounced after exposure to NMF as evidenced by a marked increase in the creatin…