Search results for "CRS"
showing 10 items of 15 documents
Effects of a Vibro-Tactile P300 Based Brain-Computer Interface on the Coma Recovery Scale-Revised in Patients With Disorders of Consciousness
2020
Persons diagnosed with disorders of consciousness (DOC) typically suffer from motor and cognitive disabilities. Recent research has shown that non-invasive brain-computer interface (BCI) technology could help assess these patients’ cognitive functions and command following abilities. 20 DOC patients participated in the study and performed 10 vibro-tactile P300 BCI sessions over 10 days with 8–12 runs each day. Vibrotactile tactors were placed on the each patient’s left and right wrists and one foot. Patients were instructed, via earbuds, to concentrate and silently count vibrotactile pulses on either their left or right wrist that presented a target stimulus and to ignore …
Multi Parametric Advanced Research tool for meteo satellite data interfacing with space observation of Ultra High Energy Cosmic Rays.
2006
To approach the study of the cosmic rays in the energy range E > 10 20 eV, the upper end of the spectrum observed to date, with a large statistical significance (103 events/year), and hence address the solution of several astrophysical and cosmological problems related to their existence and behaviour, a new generation of experiments will probably have to be conceived and realised. They will be based on the observation and measurements of cosmic rays from space. The extremely low rate of these events (∼ 1 event/(century × km2 × sr)) imposes a very large effective area to be monitored, of the order of 105km2, as an observational requirement to meet the target statistics. The Extreme Universe…
Rationale and evidence on the use of tocilizumab in COVID-19: a systematic review
2020
Abstract Background Tocilizumab is an IL-6 receptor-blocking agent proposed for the treatment of severe COVID-19. The aim of this systematic review was to describe the rationale for the use of tocilizumab for the treatment of COVID-19 and to summarize the available evidence regarding its efficacy and safety. Methods MEDLINE, PubMed, EMBASE, pre-print repositories (bioRxiv and medRxiv) and two trial Registries were searched for studies on the use of tocilizumab in COVID-19 or SARS-CoV-2 infection, viral pneumonia, and/or sepsis until 20th June 2020. Results We identified 3 indirect pre-clinical studies and 28 clinical studies including 5776 patients with COVID-19 (13 with a comparison group,…
Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)
2020
According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored al…
Likumprojektu "Ārvalstu kontu nodokļu pienākuma izpilde (FATCA)" un "Vienotais ziņošanas standarts (CRS)" izpēte un analīze
2015
Izvairīšanās no nodokļu nemaksāšanas un „caurumu” meklēšana likumdošanā, kļūst par lielu problēmu valstu nodokļu institūcijām. Mūsdienās ar tehnoloģiju palīdzību visu var izdarīt attālināti, un tāpat arī pārvest lielus naudas līdzekļus uz „nodokļu paradīzes valstīm”. Šāda finanšu neuzrādīšana rada lielus zaudējumus valstu finanšu stāvoklim. Ar likumprojektiem FATCA un CRS globālā mērogā vēlas samazināt nodokļu apiešanu globāli. Darba mērķis ir izanalizēt un salīdzināt nodokļu likumprojektu „FATCA” un „CRS” sarežģītību un lietderību to ieviešanā, kā arī izstrādāt priekšlikumus šo likumprojektu prasību efektīvākai datu apkopošanai. Maģistra darba autors pētīja saistībā ar FATCA un CRS likumpr…
Tratamiento de las ectasias corneales asociadas a LASIK con anillos intraestromales
2022
INTRODUCCIÓN: La ectasia corneal es una de sus complicaciones más graves de la cirugía LASIK. Está asociada a un adelgazamiento y un progresivo incurvamiento corneal y los anillos intracorneales (ICRS) se han propuesto como opción terapéutica debido a que inducen un aplanamiento. OBJETIVO: Evaluar los cambios producidos por los ICRS en pacientes diagnosticados de ectasias secundarias a LASIK. MATERIAL Y MÉTODOS: Es un estudio retrospectivo donde se incluyeron 26 ojos con ectasia post-LASIK los cuales fueron tratados con ICRS tipo Ferrara (AJL, Vitoria). Se les realizó un examen refractivo (agudeza visual (AV) y la refracción subjetiva). Mediante Pentacam®HR (Oculus: OtikgerateGmbH, Wetzlar,…
Impact of Si on the high-temperature oxidation of AlCr(Si)N coatings
2022
The resistance of wear protective coatings against oxidation is crucial for their use at high temperatures. Here, three nanocomposite AlCr(Si)N coatings with a fixed Al/Cr atomic ratio of 70/30 and a varying Si-content of 0 at.%, 2.5 at.% and 5 at.% were analyzed by differential scanning calorimetry, thermogravimetric analysis and X-ray in order to understand the oxidation behavior depending on their Si-content. Additionally, a partially oxidized AlCrSiN coating with 5 at.% Si on a sapphire substrate was studied across the coating thickness by depth-resolved cross-sectional X-ray nanodiffraction and scanning trans-mission electron microscopy to investigate the elemental composition, morphol…
Desired cybersecurity skills and skills acquisition methods in the organizations
2022
Abstract:Key personnel and their competences play important roles in continuity management and improving resilience of cybersecurity in organizations. Researchers have addressed many topics and studies in the cybersecurity domain. However, relevant cybersecurity skills and acquisition of them in expertise development, have only been partially touched. If designed systematically and properly, cybersecurity training can improve cybersecurity expertise to ensure better performance in complex cybersecurity situations. More through study on the acquisition of cybersecurity skills, and work-life needs are needed. The research three questions of this study are: How do work-life representatives see…
Intranasal oxytocin decreases fear generalization in males, but does not modulate discrimination threshold
2021
Background: A previously acquired fear response often spreads to perceptually or conceptually close stimuli or contexts. This process, known as fear generalization, facilitates the avoidance of danger, and dysregulations in this process play an important role in anxiety disorders. Oxytocin (OT) has been shown to modulate fear learning, yet effects on fear generalization remain unknown. Methods: We employed a randomized, placebo-controlled, double-blind, between-subject design during which healthy male participants received either intranasal OT or placebo (PLC) following fear acquisition and before fear generalization with concomitant acquisition of skin conductance responses (SCRs). Twenty-…
GPCR Inhibition in Treating Lymphoma
2022
G protein-coupled receptors (GPCRs) are important classes of cell surface receptors involved in multiple physiological functions. Aberrant expression, upregulation, and mutation of GPCR signaling pathways are frequent in many types of cancers, promoting hyperproliferation, angiogenesis, and metastasis. Recent studies showed that alterations of GPCRs are involved in different lymphoma types. Herein, we review the synthetic strategies to obtain GPCR inhibitors, focusing on CXCR4 inhibitors which represent most of the GPCR inhibitors available in the market or under preclinical investigations for these diseases.