Search results for "CRS"

showing 10 items of 15 documents

GPCR Inhibition in Treating Lymphoma

2022

G protein-coupled receptors (GPCRs) are important classes of cell surface receptors involved in multiple physiological functions. Aberrant expression, upregulation, and mutation of GPCR signaling pathways are frequent in many types of cancers, promoting hyperproliferation, angiogenesis, and metastasis. Recent studies showed that alterations of GPCRs are involved in different lymphoma types. Herein, we review the synthetic strategies to obtain GPCR inhibitors, focusing on CXCR4 inhibitors which represent most of the GPCR inhibitors available in the market or under preclinical investigations for these diseases.

CXCR4G protein-coupled receptorsDLBCLOrganic ChemistryDrug DiscoverylymphomaMCLBiochemistryGPCRs

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Rationale and evidence on the use of tocilizumab in COVID-19: a systematic review

2020

Abstract Background Tocilizumab is an IL-6 receptor-blocking agent proposed for the treatment of severe COVID-19. The aim of this systematic review was to describe the rationale for the use of tocilizumab for the treatment of COVID-19 and to summarize the available evidence regarding its efficacy and safety. Methods MEDLINE, PubMed, EMBASE, pre-print repositories (bioRxiv and medRxiv) and two trial Registries were searched for studies on the use of tocilizumab in COVID-19 or SARS-CoV-2 infection, viral pneumonia, and/or sepsis until 20th June 2020. Results We identified 3 indirect pre-clinical studies and 28 clinical studies including 5776 patients with COVID-19 (13 with a comparison group,…

Coronavirus COVID-19 Pneumonia SARS-CoV-2 TocilizumabGCA Giant cell arteritispJIA Pediatric juvenile idiopathic arthritislaw.inventionchemistry.chemical_compound0302 clinical medicineRandomized controlled triallawMedicine030212 general & internal medicineClinical efficacyCPAP Continuous positive airway pressureCOVID-19 Coronavirus disease 2019IDSA Infectious Diseases Society of AmericaRA Rheumatoid arthritisTocilizumabIMV Invasive mechanical ventilationsJIA Juvenile idiopathic arthritisAIFA Agenzia Italiana del FarmacoPulmonary and Respiratory Medicinemedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MEDLINEAntibodies Monoclonal HumanizedNIH U.S. National Institutes of HealthArticleWHO World Health OrganizationSIMIT Italian Society of Infectious and Tropical disease03 medical and health sciencesTocilizumabARDS Acute respiratory distress syndromeAnimalsHumansIn patientIntensive care medicineTocilizumab ; COVID-19 ; Pneumonia ; SARS-CoV-2 ; Coronaviruslcsh:RC705-779business.industryCRS CAR-T cell-induced cytokine release syndromeInterleukin-6SARS-CoV-2NIV Noninvasive mechanical ventilationTNF Tumor necrosis factorCOVID-19Pneumonialcsh:Diseases of the respiratory systemCOVID-19 Drug TreatmentClinical trialCoronavirus030228 respiratory systemchemistrybusinessICTRP International Clinical Trials Registry PlatformPulmonology

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Does doing good do well? An investigation into the relationship between consumer buying behavior and CSR

2022

Corporate Social Responsibility (CSR) has emerged globally as an important field of study as corporations increasingly recognize the positive consequences of ethical behavior in their business operations. However, despite a growing body of literature, results and definitions remain somewhat contradictory and fractured. Taking a marketing business ethics perspective, this article examines the influence of CSR in firms and its impact on consumer buying behavior through a systematic examination of state of the art literature over the past two decades (2000–2020). Our review identifies a theoretical connection between CSR initiatives and positive consumer reaction yet a lack of material relevan…

Economics and Econometricscorporate social responsibilitybusiness.industryField (Bourdieu)Economic growth development planningconsumer purchase behaviorUNESCO::CIENCIAS ECONÓMICASEthical behaviorbusiness ethicsPublic relationsRegional economics. Space in economicsCorporate Social Responsibility; CSR; responsibility; responsibility; business ethics; ethical consumerism; consumer purchase behaviorHT388HD72-88Corporate social responsibilityresponsibilityBusinessethical consumerism;Ethical consumerismBusiness ethicscsrethical consumerismCRSEconomic research - Ekonomska istraživanja

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Tratamiento de las ectasias corneales asociadas a LASIK con anillos intraestromales

2022

INTRODUCCIÓN: La ectasia corneal es una de sus complicaciones más graves de la cirugía LASIK. Está asociada a un adelgazamiento y un progresivo incurvamiento corneal y los anillos intracorneales (ICRS) se han propuesto como opción terapéutica debido a que inducen un aplanamiento. OBJETIVO: Evaluar los cambios producidos por los ICRS en pacientes diagnosticados de ectasias secundarias a LASIK. MATERIAL Y MÉTODOS: Es un estudio retrospectivo donde se incluyeron 26 ojos con ectasia post-LASIK los cuales fueron tratados con ICRS tipo Ferrara (AJL, Vitoria). Se les realizó un examen refractivo (agudeza visual (AV) y la refracción subjetiva). Mediante Pentacam®HR (Oculus: OtikgerateGmbH, Wetzlar,…

ICRS:CIENCIAS MÉDICAS ::Cirugía ::Cirugía ocular [UNESCO]:CIENCIAS MÉDICAS ::Ciencias clínicas::Oftalmología [UNESCO]anillos intraestromalesectasias secundarias a LASIKUNESCO::CIENCIAS MÉDICAS ::Ciencias clínicas::OftalmologíaLASIKUNESCO::CIENCIAS MÉDICAS ::Cirugía ::Cirugía ocularectasia corneal

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Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)

2020

According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored al…

ISAR International Severe Asthma RegistrySHARPPediatricsSevere asthmaSA severe asthmaBiologics Oral corticosteroids Real-life Registr Severe asthmaOmalizumabforced expiratory volume in the 1st secondFood &ampGrading of Recommendations Assessmentchronic rhinosinusitis with nasal polyposisFEV1chemistry.chemical_compound0302 clinical medicineQuality of lifeEMAReal WorldEuropean Medicines AgencyBiologics; Oral corticosteroids; Real-life; Registr; Severe asthmaOral corticosteroidsFDA Food & Drug AdministrationImmunology and Allergy030223 otorhinolaryngologySevere Heterogeneous Asthma Research collaborationmusculoskeletal neural and ocular physiologyReal-lifeCRSwNPOCSsBenralizumabDupilumabCRSwNP chronic rhinosinusitis with nasal polyposisGRADESHARP Severe Heterogeneous Asthma Research collaboration Patient-centredSevere Asthma Network in ItalyFDAmedicine.drugPulmonary and Respiratory Medicinelcsh:Immunologic diseases. Allergymedicine.medical_specialtyDrug AdministrationGINA Global Initiative for AsthmaRW Real WorldImmunologymacromolecular substancesRWSettore MED/10 - Malattie Dell'Apparato RespiratorioBiologicsInternational Severe Asthma RegistryISAR03 medical and health sciencesSADisease registrySARP Severe Asthma Research ProgramPatient-centredmedicineAsthmabusiness.industrySettore MED/09 - MEDICINA INTERNASANI Severe Asthma Network in ItalySANIBiological productmedicine.diseaseOCSs Oral CorticoSteroidsGINASARPSevere Asthma Research ProgramFEV1 forced expiratory volume in the 1st second030228 respiratory systemchemistrynervous systemRegistrEMA European Medicines AgencyDevelopment and EvaluationSevere asthma Biologics Oral corticosteroids Real-life Registrbusinesslcsh:RC581-607Global Initiative for AsthmaMepolizumabGRADE Grading of Recommendations Assessment Development and Evaluation

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CCDC 1047644: Experimental Crystal Structure Determination

2017

Related Article: Michael Mirion, Lars Andernach, Caroline Stobe, Joaquin Barjau, Dieter Schollmeyer, Till Opatz, Arne Lützen, Siegfried R. Waldvogel|2015|Eur.J.Org.Chem.|2015|4876|doi:10.1002/ejoc.201500600

Space GroupCrystallographyCrystal SystemCrystal Structure(5aSR7RS8aRS8cRS13bSR)-Ethyl-247101213b15-heptamethyl-568-trioxa-(benzo[h]-(benzo[b]furo)[23-b]-[4.3.3]propellan)-14-eneCell ParametersExperimental 3D Coordinates

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CCDC 1047645: Experimental Crystal Structure Determination

2017

Space GroupCrystallographyCrystal SystemCrystal Structure(5aSR8aRS8cRS13bSR)-24101213b15-Hexamethyl-568-trioxa-spiro[cyclohexakis(benzo[h](benzo[b]furo)[23-b]-[4.3.3]propellan)]-14-eneCell ParametersExperimental 3D Coordinates

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CCDC 1047647: Experimental Crystal Structure Determination

2017

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(5aSR8aRS8cRS13bSR)-8-Aza-56-dioxa-24101213b15-hexamethyl-N-phenyl-(benzo[h]-(benzo[b]furo)[23-b]-[4.3.3]propellan)-14-ene-7-oneExperimental 3D Coordinates

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Impact of Si on the high-temperature oxidation of AlCr(Si)N coatings

2022

The resistance of wear protective coatings against oxidation is crucial for their use at high temperatures. Here, three nanocomposite AlCr(Si)N coatings with a fixed Al/Cr atomic ratio of 70/30 and a varying Si-content of 0 at.%, 2.5 at.% and 5 at.% were analyzed by differential scanning calorimetry, thermogravimetric analysis and X-ray in order to understand the oxidation behavior depending on their Si-content. Additionally, a partially oxidized AlCrSiN coating with 5 at.% Si on a sapphire substrate was studied across the coating thickness by depth-resolved cross-sectional X-ray nanodiffraction and scanning trans-mission electron microscopy to investigate the elemental composition, morphol…

TechnologyThermogravimetric analysisSTRESSMaterials sciencePolymers and PlasticsAnnealing (metallurgy)Materials SciencenanomateriaalitOxideTHERMAL-STABILITYMaterials Science Multidisciplinaryengineering.materialoxidation behaviourchemistry.chemical_compoundDifferential scanning calorimetryCoatingResidual stressMaterials ChemistrykomposiititpinnoitteetScience & TechnologyAlCrSiNNanocompositenanocompositeMechanical EngineeringhapettuminenMetals and AlloysMECHANICAL-PROPERTIESEVOLUTIONcross-sectional X-ray nanodiffractionALChemical engineeringchemistryMechanics of MaterialsCeramics and CompositesengineeringMetallurgy & Metallurgical EngineeringAtomic ratioALCRN COATINGSRESISTANCEBEHAVIORSYSTEMNANOCOMPOSITE COATINGScathodic arcJournal of Materials Science & Technology

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Multi Parametric Advanced Research tool for meteo satellite data interfacing with space observation of Ultra High Energy Cosmic Rays.

2006

To approach the study of the cosmic rays in the energy range E > 10 20 eV, the upper end of the spectrum observed to date, with a large statistical significance (103 events/year), and hence address the solution of several astrophysical and cosmological problems related to their existence and behaviour, a new generation of experiments will probably have to be conceived and realised. They will be based on the observation and measurements of cosmic rays from space. The extremely low rate of these events (∼ 1 event/(century × km2 × sr)) imposes a very large effective area to be monitored, of the order of 105km2, as an observational requirement to meet the target statistics. The Extreme Universe…

cosmic raysrays UHECRsenergy

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