Search results for "CSF"

showing 8 items of 48 documents

The reconstructive role of TachoSil in neurosurgery

2016

Abstract Hemorrhages, cerebrospinal fluid (CSF) fistula and infections are the most challenging post-operative complications in Neurosurgery [1–5]. Fibrin sealant agents have been developed with the aim to provide efficient hemostasis and safe dural closure [3,6–14]. In this study we report our initial experience using TachoSil® (haemostatic surgical patch; Nycomed, Linz, Austria) in achieving hemostasis and CSF leakage repair during cranio-cerebral procedures [15–18]. We describe and show the unique features of this fibrin sealant, pioneered with stunning success in many surgical procedures known to be at high risk of peri- and postoperative bleeding (i.e. nephrectomies, pulmonary lobectom…

medicine.medical_specialtyFistulalcsh:Surgery030204 cardiovascular system & hematologylcsh:RC346-429Fibrin03 medical and health sciences0302 clinical medicineMedicineCsf leakagelcsh:Neurology. Diseases of the nervous systembiologySettore MED/27 - Neurochirurgiabusiness.industrylcsh:RD1-811TachoSilSurgical proceduresmedicine.diseaseTachosilSurgeryHemostasisbiology.proteinSurgeryDural closureNeurology (clinical)Neurosurgerybusiness030217 neurology & neurosurgeryInterdisciplinary Neurosurgery
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The Quest for Predictors of Shunt-Dependent Chronic Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage: Toward a Tailored Approach for Permanent …

2021

AdultAneurysmal subarachnoid hemorrhage Cerebrospinal fluid (CSF) output External ventricular drainage Hydrocephalus Adult Cerebrospinal Fluid Shunts Chronic Disease Aged Humans Hydrocephalus Ventriculoperitoneal Shunt Predictive Value of Tests Middle Aged Subarachnoid Hemorrhage Risk Assessment Prognosis Treatment OutcomeCerebrospinal fluid (CSF) output2019-20 coronavirus outbreakmedicine.medical_specialtySubarachnoid hemorrhageCoronavirus disease 2019 (COVID-19)Aneurysmal subarachnoid hemorrhageSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Risk AssessmentVentriculoperitoneal ShuntPredictive Value of TestsmedicineHumansAgedbusiness.industryExternal ventricular drainageMiddle AgedSubarachnoid Hemorrhagemedicine.diseasePrognosisChronic hydrocephalusCerebrospinal Fluid ShuntsHydrocephalusShunt (medical)SurgeryTreatment OutcomeChronic DiseaseSurgeryNeurology (clinical)businessHydrocephalus
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Dynamics of a financial market index after a crash

2002

We discuss the statistical properties of index returns in a financial market just after a major market crash. The observed non-stationary behavior of index returns is characterized in terms of the exceedances over a given threshold. This characterization is analogous to the Omori law originally observed in geophysics. By performing numerical simulations and theoretical modelling, we show that the nonlinear behavior observed in real market crashes cannot be described by a GARCH(1,1) model. We also show that the time evolution of the Value at Risk observed just after a major crash is described by a power-law function lacking a typical scale.

Statistics and ProbabilityStatistical Finance (q-fin.ST)Index (economics)Actuarial scienceStatistical Mechanics (cond-mat.stat-mech)EconophysicsScale (ratio)Autoregressive conditional heteroskedasticityFinancial marketFOS: Physical sciencesQuantitative Finance - Statistical FinanceCrashFunction (mathematics)Condensed Matter PhysicsFOS: Economics and businessEconophysicsFinancial marketsCrashesValue at RiskEconometricsEconomicsCondensed Matter - Statistical MechanicsValue at riskPhysica A: Statistical Mechanics and its Applications
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Clinical Use of κ Free Light Chains Index as a Screening Test for Multiple Sclerosis.

2020

Abstract Objective To assess the usefulness of the κ free light chain index (κFLCi) as a screening test to identify patients with suspected MS. Methods The study included 56 patients with a request to test for oligoclonal bands (OCBs). OCBs were detected by isoelectric focusing, followed by immunofixation. Cerebrospinal fluid (CSF) and serum κFLC were measured by a turbidimetric assay. Also, the κFLC index (κFLCi) was calculated. Results CSF κFLC levels and κFLCi were significantly higher in patients with multiple sclerosis (MS) than in patients with other neurological diseases (NDs; P < .001 and P < .001, respectively). At the cutoff value of 2.9, the κFLCi detected MS with s…

ImmunofixationAdultMale030213 general clinical medicinemedicine.medical_specialtyMultiple SclerosisScreening testClinical BiochemistryκFLCCSFfree light chainImmunoglobulin light chainGastroenterologySensitivity and Specificity03 medical and health sciences0302 clinical medicineCerebrospinal fluidInternal medicinemedicineHumansMass ScreeningAgedOCBbiologybusiness.industryIsoelectric focusingMultiple sclerosisBiochemistry (medical)Middle AgedκFLC indexmedicine.diseaseFree Light Chainmultiple sclerosibiology.proteinbiomarkerBiomarker (medicine)FemaleImmunoglobulin Light Chainsbusiness030217 neurology & neurosurgeryBiomarkersLaboratory medicine
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CSF HOMOCYSTEINE LEVELS IN AMYOTROPHC LATERAL SCLEROSIS

2008

CSF HOMOCYSTEINEA MYOTROPHC LATERAL SCLEROSISSettore MED/26 - Neurologia
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CSF homocysteine levels in Amyotrophic Lateral Sclerosis

2008

CSF ALS
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Neurogranin as a Novel Biomarker in Alzheimer's Disease

2020

Abstract Background In this study, we investigated the possible role of 2 novel biomarkers of synaptic damage, namely, neurogranin and α-synuclein, in Alzheimer disease (AD). Methods The study was performed in a cohort consisting of patients with AD and those without AD, including individuals with other neurological diseases. Cerebrospinal fluid (CSF) neurogranin and α-synuclein levels were measured by sensitive enzyme-linked immunosorbent assays (ELISAs). Results We found significantly increased levels of CSF neurogranin and α-synuclein in patients with AD than those without AD. Neurogranin was correlated with total tau (tTau) and phosphorylated tau (pTau), as well as with cognitive declin…

MaleOncologymedicine.medical_specialtyClinical BiochemistryDiseaseSensitivity and SpecificityCerebrospinal fluidAlzheimer DiseaseInternal medicineHumansMedicineNeurograninCognitive declineAgedRetrospective StudiesReceiver operating characteristicbusiness.industryBiochemistry (medical)Area under the curveMiddle Agedmedicine.diseaseCSF biomarker neurogranin synapsis synaptic loss α-synucleinalpha-SynucleinBiomarker (medicine)FemaleNeurograninAlzheimer's diseasebusinessBiomarkers
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Critical success factors for business intelligence system implementation

2017

Business intelligence (BI) eli liiketoimintatiedon hallinta auttaa organisaatioita tekemään parempia päätöksiä nopeammin. BI-järjestelmä voidaan nähdä sarjana työkaluja, teknologioita ja ohjelmistoja, jotka tukevat päätöksentekoa. Nämä järjestelmät ovat monimutkaisia ja niiden käyttöönotto sisältää suuria riskejä sekä vaatii paljon aikaa, rahaa ja vaivaa. Tämän vuoksi on tärkeää tunnistaa tekijät, jotka ovat tärkeitä käyttöönoton onnistumisen takaamiseksi. Tämä tutkielma keskittyi tunnistamaan BI-järjestelmän käyttöönoton kriittiset menestystekijät ja ymmärtämään miksi juuri nämä tekijät ovat tärkeitä. Menestystekijät löydettiin ja niitä analysoitiin hyödyntämällä olemassaolevaa kirjallisuu…

Business IntelligenceCritical Success FactorsBICSFimplementationmenestystekijätkäyttöönotto
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