Search results for "CTB"

showing 3 items of 13 documents

Cholera-Like Enterotoxins and Regulatory T cells

2010

Cholera toxin (CT) and the heat-labile enterotoxin of E. coli (LT), as well as their non toxic mutants, are potent mucosal adjuvants of immunization eliciting mucosal and systemic responses against unrelated co-administered antigens in experimental models and in humans (non toxic mutants). These enterotoxins are composed of two subunits, the A subunit, responsible for an ADP-ribosyl transferase activity and the B subunit, responsible for cell binding. Paradoxically, whereas the whole toxins have adjuvant properties, the B subunits of CT (CTB) and of LT (LTB) have been shown to induce antigen specific tolerance when administered mucosally with antigens in experimental models as well as, rece…

Cholera ToxinHealth Toxicology and Mutagenesismedicine.medical_treatmentBacterial Toxinslcsh:MedicineEnterotoxinReviewBiologyToxicologymedicine.disease_causeT-Lymphocytes Regulatoryregulatory T cellsMicrobiologyImmune toleranceAutoimmune DiseasesEnterotoxinsImmune systemAntigenAdjuvants ImmunologicmedicineImmune ToleranceAnimalsHumansAntigen-presenting cellEscherichia coli Proteinslcsh:RCholera toxinCTBIn vitroLTBImmunologyAdjuvantheat-labile enterotoxin of E. colicholera-like enterotoxinsToxins
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2018

The pre-supplementary motor area (pre-SMA) is engaged in speech comprehension under difficult circumstances such as poor acoustic signal quality or time-critical conditions. Previous studies found that left pre-SMA is activated when subjects listen to accelerated speech. Here, the functional role of pre-SMA was tested for accelerated speech comprehension by inducing a transient "virtual lesion" using continuous theta-burst stimulation (cTBS). Participants were tested (1) prior to (pre-baseline), (2) 10 min after (test condition for the cTBS effect), and (3) 60 min after stimulation (post-baseline) using a sentence repetition task (formant-synthesized at rates of 8, 10, 12, 14, and 16 syllab…

medicine.medical_specialtySpeech perceptionRepetition (rhetorical device)Supplementary motor areaGeneral Neurosciencemedia_common.quotation_subject05 social sciencesCTBSContext (language use)Audiology050105 experimental psychologyTask (project management)03 medical and health sciences0302 clinical medicinemedicine.anatomical_structurePerceptionotorhinolaryngologic diseasesmedicine0501 psychology and cognitive sciencesPsychology030217 neurology & neurosurgerySentencemedia_commonFrontiers in Neuroscience
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Parietal Cortex Connectivity as a Marker of Shift in Spatial Attention Following Continuous Theta Burst Stimulation

2021

Non-invasive brain stimulation is a useful tool to probe brain function and provide therapeutic treatments in disease. When applied to the right posterior parietal cortex (PPC) of healthy participants, it is possible to temporarily shift spatial attention and mimic symptoms of spatial neglect. However, the field of brain stimulation is plagued by issues of high response variability. The aim of this study was to investigate baseline functional connectivity as a predictor of response to an inhibitory brain stimulation paradigm applied to the right PPC. In fourteen healthy adults (9 female, aged 24.8 ± 4.0 years) we applied continuous theta burst stimulation (cTBS) to suppress activity in the …

non-invasive brain stimulationneuroplasticityCTBSPosterior parietal cortexNeurosciences. Biological psychiatry. NeuropsychiatryStimulationElectroencephalographyInhibitory postsynaptic potentialBehavioral Neurosciencespatial attentionNeuroplasticitymedicineBiological PsychiatryOriginal ResearchResting state fMRImedicine.diagnostic_testbusiness.industryfunctional connectivityPsychiatry and Mental healthNeuropsychology and Physiological PsychologyNeurologyBrain stimulationbusinessNeuroscienceelectroencephalographyRC321-571NeuroscienceFrontiers in Human Neuroscience
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