Search results for "CTL"
showing 10 items of 521 documents
The Effects of Tamoxifen on Plasma Lipoprotein(a) Concentrations: Systematic Review and Meta-Analysis
2017
Introduction: Tamoxifen is a selective estrogen receptor modulator widely used in the treatment of breast cancer. Tamoxifen therapy is associated with reduced circulating low-density lipoprotein cholesterol and increased triglycerides, but its effects on other lipids are less-well studied. Aims: We aimed to investigate the effect of tamoxifen on circulating concentrations of lipoprotein(a) (Lp(a)) through systematic review and meta-analysis of available randomized controlled trials (RCTs) and observational studies. Methods: This study was registered in the PROSPERO database (CRD42016036890). Scopus, Medline and EMBASE were searched from inception until 22nd March 2016 to identify studies in…
Is there any place for PD-1/CTLA-4 inhibitors combination in the first-line treatment of advanced NSCLC?—A trial-level meta-analysis in PD-L1 selecte…
2021
BACKGROUND: The advent of immuno-oncology (IO) represented a breakthrough in non-small cell lung cancer (NSCLC) therapy over the last few years. However, establishing the optimal therapeutic options among programmed death-ligand 1 (PD-L1) selected subgroups still addresses an unmet need in the clinical setting. METHODS: We performed a systematic review and finally included eleven first-line randomized controlled trials to compare efficacy and safety outcomes among first-line IO treatment strategies versus standard platinum-based chemotherapy (CT) according to PD-L1 expression level (<1%, 1–49%, ≥50%). Pooled hazard ratios (HRs) and risk ratios (RRs) for progression-free survival (PFS), over…
The Peregrine soliton in nonlinear fibre optics
2010
International audience; The Peregrine soliton is a localized nonlinear structure predicted to exist over 25 years ago, but not so far experimentally observed in any physical system. It is of fundamental significance because it is localized in both time and space, and because it defines the limit of a wide class of solutions to the nonlinear Schrödinger equation (NLSE). Here, we use an analytic description of NLSE breather propagation to implement experiments in optical fibre generating femtosecond pulses with strong temporal and spatial localization, and near-ideal temporal Peregrine soliton characteristics. In showing that Peregrine soliton characteristics appear with initial conditions th…
Polarization modulation instability in a Manakov fiber system
2015
International audience; The Manakov model is the simplest multicomponent model of nonlinear wave theory: It describes elementary stable soliton propagation and multisoliton solutions, and it applies to nonlinear optics, hydrodynamics, and Bose-Einstein condensates. It is also of fundamental interest as an asymptotic model in the context of the widely used wavelength-division-multiplexed optical fiber transmission systems. However, although its physical relevance was confirmed by the experimental observation of Manakov (vector) solitons in a planar waveguide in 1996, there have in fact been no quantitative experiments confirming its validity for nonlinear dynamics other than soliton formatio…
Peregrine soliton generation and breakup in standard telecommunications fiber
2011
International audience; We present experimental and numerical results showing the generation and breakup of the Peregrine soliton in standard telecommunications fiber. The impact of non-ideal initial conditions is studied through direct cut back measurements of the longitudinal evolution of the emerging soliton dynamics, and is shown to be associated with the splitting of the Peregrine soliton into two subpulses, with each subpulse itself exhibiting Peregrine soliton characteristics. Experimental results are in good agreement with simulations.
Analysis and design of elastic plastic structures subjected to dynamic loads
In the last decades, the concept of “optimization” has reached considerable value in many different fields of scientific research and, in particular, it has assumed great importance in the field of structural mechanics. The present study describes and shows the scientific path followed in the three years of doctoral studies. The state of the art concerning the optimization of elastic plastic structures subjected to quasi-static loads was already well established at the beginning of the Ph.D. course. Actually, it was already faced the study of structures subjected to quasi-static cyclic loads able to ensure different structural behaviors in relation to different intensity levels of the appli…
CTLA4-Linked Autoimmunity in the Pathogenesis of Endometriosis and Related Infertility: A Systematic Review
2022
Several studies, although with conflicting results, have sought to determine the concentration of soluble CTLA4 antigens in peripheral blood plasma and peritoneal fluid in patients with endometriosis-related infertility. A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) through a search of the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library, Health Technology Assessment Database and Web of Science, and Clinical Trials research register. We included observational or prospective human and animal studies with any features related to endometriosis and/or infertility studies involving CTLA4-rel…
Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells.
2010
Abstract Cross-presentation of soluble Ag on MHC class I molecules to naive CD8 T cells by liver sinusoidal endothelial cells (LSECs) leads to induction of T cell tolerance that requires interaction between coinhibitory B7-H1 on LSECs and programmed cell death-1 on CD8 T cells. In this study, we investigate whether cross-presentation of high as well as low Ag concentrations allowed for LSEC-induced tolerance. Ag concentration directly correlated with the cross-presentation capacity of murine LSECs and thus strength of TCR stimulation. Although LSEC cross-presentation at low-Ag concentrations resulted in tolerance, they induced differentiation into effector T cells (CTL) at high-Ag concentra…
"Table 2" of "Comprehensive measurements of $t$-channel single top-quark production cross sections at $\sqrt{s} = 7$ TeV with the ATLAS detector"
2021
Detailed list of the contribution of each source of uncertainty to the total uncertainty on the measured values of $\sigma(tq)$, $\sigma(\bar{t}q)$, $R_t$, and $\sigma(tq+\bar{t}q)$. The evaluation of the systematic uncertainties has a statistical uncertainty of $0.3\,\%$. Uncertainties contributing less than $1.0\,\%$ are marked with "$<1$" in the paper. To provide numerical values for this table in HEPdata, these uncertainties are approximated with $\pm 0.5\,\%$. This approximation is applied to all measurements for the following uncertainties$:$ JES statistical, JES physics modeling, JES mixed detector and modeling, JES close-by-jets, JES pileup, $b$-JES, jet vertex fraction, mistag e…
"Table 4" of "Comprehensive measurements of $t$-channel single top-quark production cross sections at $\sqrt{s} = 7$ TeV with the ATLAS detector"
2021
Parametrization factors for the $m_{t}$ dependence [see Eq. (4) in the paper] of $\sigma(tq)$, $\sigma(\bar tq)$, and $\sigma(t q+\bar t q)$.