Search results for "Caliza"
showing 10 items of 656 documents
Localización y convicción en las alucinaciones auditivas en psicosis
2017
La tesis doctoral, en su introducción presenta una reseña histórica del concepto de alucinación y su desarrollo en la práctica clínica a través del tiempo hasta la actualidad. Después de la introducción, se muestra una propuesta de clasificación de las alucinaciones teniendo en cuenta diversos criterios, en los que se han basado clasificaciones anteriores. 1. Alucinaciones orgánicas 2. Alucinaciones no orgánicas 3. Pseudoalucinaciones 4. Clasificación de las alucinaciones según su modalidad sensorial (independientemente de que sean orgánicas o no orgánicas) Posteriormente y ya con carácter más concreto, el desarrollo del presente trabajo se centra en el fenómeno pseudoalucinatorio, motivo p…
A Deletion of the Nuclear Localization Signal Domain in the Fus Protein Induces Stable Post-stress Cytoplasmic Inclusions in SH-SY5Y Cells
2021
Mutations in Fused-in-Sarcoma (FUS) gene involving the nuclear localization signal (NLS) domain lead to juvenile-onset Amyotrophic Lateral Sclerosis (ALS). The mutant protein mislocalizes to the cytoplasm, incorporating it into Stress Granules (SG). Whether SGs are the first step to the formation of stable FUS-containing aggregates is still unclear. In this work, we used acute and chronic stress paradigms to study the SG dynamics in a human SH-SY5Y neuroblastoma cell line carrying a deletion of the NLS domain of the FUS protein (homozygous: ΔNLS–/–; heterozygous: ΔNLS+/–). Wild-type (WT) cells served as controls. We evaluated the subcellular localization of the mutant protein through immuno…
Unveiling the Unexpected Reactivity of Electrophilic Diazoalkanes in [3+2] Cycloaddition Reactions within Molecular Electron Density Theory
2021
The [3+2] cycloaddition (32CA) reactions of strongly nucleophilic norbornadiene (NBD), with simplest diazoalkane (DAA) and three DAAs of increased electrophilicity, have been studied within the Molecular Electron Density Theory (MEDT) at the MPWB1K/6-311G (d,p) computational level. These pmr-type 32CA reactions follow an asynchronous one-step mechanism with activation enthalpies ranging from 17.7 to 27.9 kcal·
1988 06. Documentos del Vº Congreso del PSPV-PSOE. El proyecto de la mayoría. Valencia, 3-5 de junio 1988
2014
1988 06. Documentos del Vº Congreso del PSPV-PSOE. El proyecto de la mayoría. Valencia, 3-5 de junio 1988. Los documentos del 5º congreso del PSPV-PSOE que se recogen son: Informe sobre modificación del artículo 14 de los estatutos del PSPV-PSOE aprobados en el 4º congreso. Propuesta de reducir las 36 comarcas actuales a 21 en las Resoluciones del 5º Congreso. Estatutos. Guía orgánica del PSPV-PSOE, y las resoluciones del congreso. Censo de militantes. Dossier de prensa del congreso.
Auxiliaries
2014
The prototypical auxiliary in Ancient Greek is eimí “to be”, which is involved in some participial periphrases conveying aspectual value and variously interacting with the synthetic forms within the inflectional paradigm. However, many other verbs are involved in the Greek periphrastic constructions, although their status as auxiliaries is still a matter of debate. Resent research in grammaticalization allows to describe the entire range of such verbs in prototypical terms, that is, as a coherent category which includes more central and peripheral, i.e. less grammaticalized members.
Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C
2020
Macroautophagy is a conserved degradative process for maintaining cellular homeostasis and plays a key role in aging and various human disorders. The microtubule-associated protein 1A/1B light chain 3B (MAP1LC3B or LC3B) is commonly analyzed as a key marker for autophagosomes and as a proxy for autophagic flux. Three paralogues of the LC3 gene exist in humans: LC3A, LC3B and LC3C. The molecular function, regulation and cellular localization of LC3A and LC3C have not been investigated frequently, even if a similar function to that described for LC3B appears likely. Here, we have selectively decapacitated LC3B by three separate strategies in primary human fibroblasts and analyzed the evoked e…
Impediments to localization agenda : humanitarian space in the Rohingya response in Bangladesh
2022
The article spotlights the impediments of the localization agenda in the Rohingya response in Bangladesh through the notion of humanitarian space. The Rohingyas rely entirely on material aid and humanitarian services in the camps, mainly stemming from international actors committed to the localization agenda, which, however, has not been effectively implemented. Drawing on the definition of humanitarian space as an arena, we investigate the main negotiations within humanitarian space in the Rohingya response and how they impede the realization of the localization agenda. We conducted secondary data analysis on reports published by organizations involved and validated the findings with ten t…
The influence of high pressure processing on antimutagenic activities of fruit and vegetable juices
1997
Abstract In model experiments using the Salmonella/reversion assay (Ames test) and the carcinogen 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ), antimutagenic activities against IQ had been detected in about 70% of 62 fruit and vegetable species [Edenharder, Kurz, John, Burgard and Seeger (1994) Fd Chem. Toxic. 32, 443–459]. However, thermal stability of the antimutagenic factors varied considerably. As hydrostatic pressure is an alternative to heat in food processing and preservation, homogenates of 14 fruit and vegetable species were exposed to different pressures and temperatures. According to the response of the antimutagenic potential, three groups of produce could be identified: (a) m…
Cellular and Subcellular Localization of Peroxidase Isoenzymes in Plants and Cell Suspension Cultures from Lupinus polyphyllus
1989
Abstract , leaf protoplasts and cell suspension cultures of Lupinus polyphyllus and isolated vacuoles were studied for cellular and subcellular localization of peroxidase isoenzymes. Isoelectric focusing revealed 16 peroxidase isoenzymes. The basic peroxidase isoenzymes are predominantly localized in the vacuole and, to a minor degree, unbound in the intercellular space. The acidic isoenzymes are cell wall-bound in plants and not detectable in suspension-cultured cells. Large amounts (up to 11.0 U/ml) of a single basic isoenzyme are detectable in the spent medium of cell suspension cultures.
Subcellular distribution of calpain-1 and calpain-2 as a key event for calpain-mediated functions in physiological and neoplastic mammary models
2019
Calpains are a family of calcium-dependent proteases, which modulate their substrates rather than degrade them in such a way that modifies them. Calpains deregulations have been determined as an aggravating factor of different diseases, including cancer. Nevertheless, there are no clear records about the particular contribution of each calpain isoform in physiological processes and how these isoforms are deregulated in pathological conditions. In vivo, each calpain isoform recognizes specific proteins as substrates, and it has been suggested that calpains subcellular localization might determine their substrate recognition, and consequently their functions. In the present study we have expl…