Search results for "Carbenicillin"

showing 3 items of 3 documents

Antibiotic Resistance of Gram Negatives isolates from loggerhead sea turtles (Caretta caretta) in the central Mediterranean Sea

2009

Previous studies on fish and marine mammals support the hypothesis that marine species harbor antibiotic resistance and therefore may serve as reservoirs for anti biotic-resistance genetic determinants. The aim of this study was to assess the resistance to antimicrobial agents of Gram negative strains isolated from loggerhead sea turtles (Caretta caretta). Oral and cloacal swabs from 19 live-stranded loggerhead sea turtles, with hooks fixed into the gut, were analyzed. The antimicrobial resistance of the isolates to 31 antibiotics was assessed using the disk-diffusion method. Conventional biochemical tests identified Citrobacter spp., Proteus spp., Enterobacter spp., Escherichia spp., Provi…

Antibiotic resistanceAquatic ScienceBiologySettore MED/42 - Igiene Generale E ApplicataOceanographyProvidenciaLoggerhead sea turtleMicrobiologyCloacal bacteriaAntibiotic resistanceMorganellaDrug Resistance Multiple BacterialGram-Negative BacteriaMediterranean SeamedicineAnimalsAntibiotic resistance; Antimicrobials; Loggerhead sea turtle; Caretta caretta; Cloacal bacteria; Mediterranean seaCitrobacterMDR Gram negatives Caretta caretta antibiotic resistanceCaretta carettaAntimicrobialsProvidencia rettgeriCarbenicillinbiology.organism_classificationPollutionAnti-Bacterial AgentsTurtlesCitrobacter freundiiLoggerhead sea turtlebacteriahuman activitiesWater Pollutants ChemicalEnvironmental Monitoringmedicine.drugMarine Pollution Bulletin
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�ber die Neurotoxizit�t von Carbenicillin

1974

Die neurotoxische Wirkung von Carbenicillin wurde am wachen Kaninchen untersucht. Die Neurotoxizitat wurde bestimmt anhand von EEG-Veranderungen wie Spikes, Polyspikes and Spike-wave-Paroxysmen. Den Tieren wurden 2,4 g/kg Carbenicillin uber 50 min intravenos infundiert. Bis 2 Std nach Infusionsbeginn wurden zu bestimmten Zeitpunkten die Carbenicillinblutspiegel gemessen. Spikes als erstes neurotoxisches Symptom waren regelmasig bei Blutspiegeln von 3252±186 µg/ml zu beobachten. Nach Carbenicillin waren die toxischen Veranderungen wesentlich ausgepragter als nach Ampicillin, jedoch deutlich geringer als nach Penicillin G. Diese Ergebnisse stehen im Einklang mit den in klinischen Fallberichte…

Gynecologymedicine.medical_specialtybusiness.industryDrug DiscoverymedicineMolecular MedicineGeneral MedicineCarbenicillinbusinessGenetics (clinical)medicine.drugKlinische Wochenschrift
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Side-Effects of High-Dose Dicloxacillin Therapy

1976

The limiting toxic factor in high-dose penicillin therapy seems to be the effect on the central nervous system. In comparison with other semisynthetic penicillins dicloxacillin is the most neurotoxic in rabbits, as previous studies have shown (11). In rabbits neurotoxic serum levels also produce hemolysis. Cloxacillin, oxacillin and carbenicillin showed to be less neurotoxic and did not induce hemolysis. The present study was undertaken to determine whether in high-dose dicloxacillin therapy hemolysis is likely in man and is, therefore, of clinical importance.

business.industryInterstitial nephritisCentral nervous systemPharmacologyCarbenicillinmedicine.diseaseDicloxacillinHemolysisPenicillinchemistry.chemical_compoundmedicine.anatomical_structureCloxacillinchemistrypolycyclic compoundsmedicineUric acidbusinessmedicine.drug
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