6533b82efe1ef96bd12945cb

RESEARCH PRODUCT

Side-Effects of High-Dose Dicloxacillin Therapy

D. HöfflerW. PrellwitzT. R. WeihrauchH. Köhler

subject

business.industryInterstitial nephritisCentral nervous systemPharmacologyCarbenicillinmedicine.diseaseDicloxacillinHemolysisPenicillinchemistry.chemical_compoundmedicine.anatomical_structureCloxacillinchemistrypolycyclic compoundsmedicineUric acidbusinessmedicine.drug

description

The limiting toxic factor in high-dose penicillin therapy seems to be the effect on the central nervous system. In comparison with other semisynthetic penicillins dicloxacillin is the most neurotoxic in rabbits, as previous studies have shown (11). In rabbits neurotoxic serum levels also produce hemolysis. Cloxacillin, oxacillin and carbenicillin showed to be less neurotoxic and did not induce hemolysis. The present study was undertaken to determine whether in high-dose dicloxacillin therapy hemolysis is likely in man and is, therefore, of clinical importance.

yearjournalcountryeditionlanguage
1976-01-01
https://doi.org/10.1007/978-1-4684-3123-0_47