Search results for "Dicloxacillin"
showing 2 items of 2 documents
Cerebral toxicity of penicillins in relation to their hydrophobic character
1975
The neurotoxic effects of ticarcillin, methicillin, phenthicillin, oxacillin, cloxacillin and dicloxacillin were studied in the conscious rabbit. During and after intravenous administration of 1.2 and 2.4 g/kg, resp., over 50 min the blood concentrations of the drugs were determined and the neurotoxicity assessed by continuous recording of the electroencephalogram. The hydrophobia of the penicillins was characterized by determination of their partition coefficients between isobutanol and buffer solution pH 7.4. The penicillins showed quite different neurotoxic properties. A close correlation (r = 0.928) was found between the neurotoxic potency of the penicillins and their partition coeffici…
Side-Effects of High-Dose Dicloxacillin Therapy
1976
The limiting toxic factor in high-dose penicillin therapy seems to be the effect on the central nervous system. In comparison with other semisynthetic penicillins dicloxacillin is the most neurotoxic in rabbits, as previous studies have shown (11). In rabbits neurotoxic serum levels also produce hemolysis. Cloxacillin, oxacillin and carbenicillin showed to be less neurotoxic and did not induce hemolysis. The present study was undertaken to determine whether in high-dose dicloxacillin therapy hemolysis is likely in man and is, therefore, of clinical importance.