Search results for "Cardiovascular disease"

Resistance Training Induces Antiatherogenic Effects on Metabolomic Pathways

2019

Introduction: Arising evidence suggests that resistance training has the potential to induce beneficial modulation of biomarker profile. To date, however, only immediate responses to resistance training have been investigated using high-throughput metabolomics whereas the effects of chronic resistance training on biomarker profile have not been studied in detail. Methods: A total of 86 recreationally active healthy men without previous systematic resistance training background were allocated into i) a resistance training (RT) group (n=68, age 33 ± 7 years, body mass index (BMI) 28 ± 3 kg/m2 ) and ii) a non-RT group (n=18, age 31 ± 4 years, BMI 27 ± 3 kg/m2 ). Blood samples were collected at…

Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study

2014

[Background] It is unknown whether individuals at high cardiovascular risk sustain a benefit in cardiovascular disease from increased olive oil consumption. The aim was to assess the association between total olive oil intake, its varieties (extra virgin and common olive oil) and the risk of cardiovascular disease and mortality in a Mediterranean population at high cardiovascular risk.

Cardiovascular disease: pathophysiological mechanisms

2015

OSA is a common disease that affects approximately 10% of the middle-aged population and becomes more prevalent with age. It is caused by intermittent and repetitive collapse of the UA during sleep. The main acute physiological consequences of OSA are oxygen desaturation, intrathoracic pressure changes and arousals. OSA is associated with significant cardiovascular morbidity and mortality and is an independent risk factor for CVD. The pathogenesis of CVD in OSA is not completely understood but is likely to be multifactorial, involving a diverse range of closely interrelated and detrimental intermediate mechanisms that predispose patients to atherosclerosis, including oxidative stress, sympa…

Sex differences in correlates of intermediate phenotypes and prevalent cardiovascular disease in the general population

2015

Background: There are marked sex differences in cardiovascular disease (CVD) manifestation. It is largely unknown how the distribution of CVD risk factors or intermediate phenotypes explain sex-specific differences. Methods and Results: In 5000 individuals of the population-based Gutenberg Health Study, mean age 55 ± 11 years, 51% males, we examined sex-specific associations of classical CVD risk factors with intima-media thickness, ankle-brachial index, flow-mediated dilation, peripheral arterial tonometry, echocardiographic, and electrocardiographic variables. Intermediate cardiovascular phenotypes were related to prevalent CVD [coronary artery disease, heart failure, stroke, myocardial i…

3-NPA induziert Ischämietoleranz der Rattenleber nach warmer Ischämie

2005

Until now little is known about the potential of 3-nitroproprionic acid (3-NPA) to reduce ischemia/ reperfusion injury (IRI) of the rat liver in vivo.

Association between resting blood pressure and maximal blood pressure response to exercise and arterial health

2022

We investigated the longitudinal associations of blood pressure, cardiorespiratory fitness, and arterial stiffness among children. Arterial stiffening has been repeatedly shown to be a cardiovascular mortality predictor and can be observed early in childhood. As such, it is crucial to understand whether a child’s blood pressure, fitness level, and body composition can predict early signs of atherosclerosis and arterial stiffening. The current study examined the relationship between blood pressure, cardiorespiratory fitness, and arterial stiffness over time in children, using data from the Physical and Nutrition in Children (PANIC) Study. It is a physical and dietary intervention study condu…

Longitudinal and cross-sectional associations of adherence to 24-hour movement guidelines with cardiometabolic risk

2022

This study aimed to examine 1) adherence to 24-hour movement guidelines over a 2-year follow-up in children aged 6-8 years and 2) association of this adherence with cardiometabolic risk factors. Physical activity and sleep were assessed by a monitor combining heart rate and accelerometry measurements. Screen time was reported by the parents. Body fat percentage, waist circumference, blood glucose, serum insulin, plasma lipids and blood pressure were assessed, and a cardiometabolic risk score was calculated using z-scores. Children were classified as meeting the guidelines if they had on average ≥60min/day of moderate-to-vigorous physical activity during the valid days; ≤120min/day of screen…

Decompressive Craniectomy Improves QTc Interval in Traumatic Brain Injury Patients

2020

Background: Traumatic brain injury (TBI) is commonly associated with cardiac dysfunction, which may be reflected by abnormal electrocardiograms (ECG) and/or contractility. TBI-related cardiac disorders depend on the type of cerebral injury, the region of brain damage and the severity of the intracranial hypertension. Decompressive craniectomy (DC) is commonly used to reduce intra-cranial hypertension (ICH). Although DC decreases ICH rapidly, its effect on ECG has not been systematically studied. The aim of this study was to analyze the changes in ECG in patients undergoing DC. Methods: Adult patients without previously known cardiac diseases treated for isolated TBI with DC were studied. EC…

Wytyczne PTL/KLRWP/PTK/PTDL/PTD/PTNT diagnostyki i leczenia zaburzeń lipidowych w Polsce 2021

2021

Diagnosis and prognosis of cardiovascular diseases by means of texture analysis in magnetic resonance imaging

2017

Cardiovascular diseases constitute the leading global cause of morbidity and mortality. Magnetic resonance imaging (MRI) has become the gold standard technique for the assessment of patients with myocardial infarction. However, limitations still exist thus new alternatives are open to investigation. Texture analysis is a technique that aims to quantify the texture of the images that are not always perceptible by the human eye. It has been successfully applied in medical imaging but applications to cardiac MRI (CMR) are still scarce. Therefore, the purpose of this thesis was to apply texture analysis in conventional CMR images for the assessment of patients with myocardial infarction, as an …