Search results for "Cardiovascular diseases."

showing 10 items of 2156 documents

Hypoplasia of the posterior mitral valve leaflet: Don't forget to look beyond the mitral valve.

2020

Hypoplasia of the posterior mitral valve leaflet (PMVL) is a very rare finding in adulthood and can coexist with other congenital heart defects. In this image, a transesophageal echocardiography (TOE) carried out on a 59-year-old woman with a 2-month history of dyspnea revealed a hypoplastic PMVL causing severe mitral regurgitation associated with a secundum-type atrial septal defect (ASD) with left-to-right shunting. This case demonstrates how essential 3-dimensional TOE is for a comprehensive assessment of the mitral valve and to improve the diagnostic accuracy of concomitant congenital heart abnormalities.

Adultmedicine.medical_specialtyHeart malformationDiagnostic accuracy030204 cardiovascular system & hematologyHeart Septal Defects AtrialPosterior mitral valve leaflet03 medical and health sciences0302 clinical medicineMitral valveInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingcardiovascular diseases030212 general & internal medicineMitral regurgitationMitral Valve Prolapsebusiness.industryMitral Valve InsufficiencyMiddle Agedmedicine.diseaseHypoplasiaShuntingmedicine.anatomical_structurecardiovascular systemCardiologyMitral ValveFemaleCardiology and Cardiovascular MedicinebusinessEchocardiography TransesophagealEchocardiography (Mount Kisco, N.Y.)REFERENCES
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The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage

2021

Spontaneous intracerebral hemorrhage (ICH) causes, besides the primary brain injury, a secondary brain injury (SBI), which is induced, amongst other things, by oxidative stress (OS) and inflammation, determining the patient’s outcome. This study aims to assess the impact of OS in plasma and cerebrospinal fluid (CSF) on clinical outcomes in patients with ICH. A total of 19 ICH (volume &gt

Adultmedicine.medical_specialtyInflammationmedicine.disease_causeBiochemistryGastroenterologyMicrobiologyArticlecerebrospinal fluidSuperoxide dismutasechemistry.chemical_compoundCerebrospinal fluidInternal medicineMalondialdehydemedicineHumansoxidative stresscardiovascular diseasesMolecular Biologyneurological outcomeCerebral Hemorrhagechemistry.chemical_classificationIntracerebral hemorrhageGlutathione Peroxidasebiologybusiness.industryGlutathione peroxidaseGlutathioneMiddle AgedMalondialdehydemedicine.diseaseintracerebral hemorrhageQR1-502nervous system diseaseschemistrybiology.proteinmedicine.symptombusinessOxidative stressoxidative stress markersBiomolecules
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Cardiac manifestations of Anderson-Fabry disease in heterozygous females.

2002

AbstractObjectivesWe sought to define the prevalence of cardiac involvement in female patients with Anderson–Fabry disease (AFD).BackgroundAnderson–Fabry disease is a rare inborn X-linked lysosomal storage disorder. Globotriaosylceramide (Gb3), the major substrate of the deficient α-galactosidase A enzyme, accumulates progressively in vulnerable cells, including the cardiovascular system. It has been believed that heterozygous females have less cardiac involvement than hemizygous males with AFD.MethodsWe performed two-dimensional echocardiographic examinations of female patients heterozygous for AFD.ResultsSince 1997, a total of 55 female patients (mean age, 39.6 years; range, 6.1 to 70.8 y…

Adultmedicine.medical_specialtyPediatricsHeterozygoteendocrine system diseasesHeart diseaseAdolescentSystoleHeart Valve DiseasesDiseaseVentricular Dysfunction LeftFemale patientotorhinolaryngologic diseasesmedicinePrevalenceHumanscardiovascular diseasesProspective StudiesSystoleProspective cohort studyChildneoplasmsAgedVascular diseasebusiness.industryAge FactorsMiddle Agedmedicine.diseaseFabry diseasehumanitiesSurgeryPedigreeAnderson-Fabry DiseaseEchocardiographyFabry Diseaselipids (amino acids peptides and proteins)FemaleHypertrophy Left VentricularCardiology and Cardiovascular MedicinebusinessJournal of the American College of Cardiology
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Micro-albuminuria as a predictor of cardiovascular damage in essential hypertension

1989

Adultmedicine.medical_specialtyPhysiologybusiness.industryBlood PressureMiddle AgedPrognosisEssential hypertensionmedicine.diseaseBlood Pressure MonitorsCircadian RhythmCardiovascular DiseasesEchocardiographyInternal medicineHypertensionMicro albuminuriaInternal MedicineCardiologyAlbuminuriaHumansMedicineCardiology and Cardiovascular MedicinebusinessGlomerular Filtration RateJournal of Hypertension
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Cardiovascular Benefits of Group Sport Interventions: Importance of Improved Fitness in Risk Reduction

2018

BACKGROUND: Physical inactivity is a leading risk factor for cardiovascular disease worldwide. Group sport participation offers a unique, engaging approach for delivering physical activity interventions, but its overall effect on cardiometabolic risk factors is unclear. OBJECTIVE: To estimate the pooled effects of community-based, recreational-level group sports on cardiometabolic risk factors and fitness parameters among adults. METHODS AND RESULTS: We systematically searched electronic databases for English articles reporting the effectiveness of recreational-level group sports, published between January 1, 1965 and January 17, 2017. We extracted baseline and end of intervention means for…

Adultmedicine.medical_specialtyPsychological interventiongroup sportliikunta030204 cardiovascular system & hematologyArticleReduction (complexity)03 medical and health sciences0302 clinical medicinemedicineHumansExerciseinterventionsinterventiorisk reductionbusiness.industryta3142riskitekijät030229 sport sciencesGeneral MedicinebenefitsfitnessCardiovascular Diseasessydän- ja verisuonitauditcardiovascular systemPhysical therapybusinessRisk Reduction BehaviorSportsMayo Clinic Proceedings
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Difference in body weight between American and Italian women with polycystic ovary syndrome: influence of the diet.

2003

BACKGROUND The study aim was to determine differences in body mass in two populations of women (USA and Italy) with polycystic ovary syndrome (PCOS), and to assess the effect of diet on body mass and cardiovascular risk factors. METHODS Pools of women with PCOS from the USA (n = 343) and Italy (n = 301), seen between 1993 and 2001, were available for assessment. From these populations, 20 women who were seen consecutively in 2001 at each site had detailed analyses of diet and cardiovascular risk factors. RESULTS In the entire group, American women had a significantly higher body mass compared with Italian women (P < 0.01). Also, the 20 women consecutively evaluated in the USA had a signific…

Adultmedicine.medical_specialtySaturated fatBody Mass Indexchemistry.chemical_compoundInsulin resistanceRisk FactorsInternal medicinemedicineHyperinsulinemiaHumansRisk factorTriglyceridesbusiness.industryCholesterolRehabilitationBody WeightCholesterol HDLFatty AcidsObstetrics and Gynecologymedicine.diseaseObesityPolycystic ovaryDietary FatsUnited StatesDietEndocrinologyReproductive MedicinechemistryItalyCardiovascular DiseasesFemaleInsulin ResistancebusinessBody mass indexPolycystic Ovary SyndromeHuman reproduction (Oxford, England)
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How should we manage atherogenic dyslipidemia in women with polycystic ovary syndrome?

2007

Despite their young age, women with polycystic ovary syndrome (PCOS) have increased cardiovascular risk. Besides normal concentrations of low-density lipoprotein (LDL) cholesterol, dyslipidemia is very common and includes elevated triglyceride levels and low high-density lipoprotein cholesterol concentrations. Recent findings also showed that women with PCOS have qualitative LDL alterations, with increased levels of atherogenic small, dense LDL particles. Such lipid abnormalities constitute a common form of dyslipidemia, the so-called atherogenic lipoprotein phenotype (ALP), associated with a greater cardiovascular risk. Weight reduction and increased physical activity may constitute first-…

Adultmedicine.medical_specialtySettore MED/09 - Medicina Interna10265 Clinic for Endocrinology and Diabetology610 Medicine & healthRisk AssessmentSeverity of Illness IndexSettore MED/13 - Endocrinologiachemistry.chemical_compoundWeight lossInternal medicinemedicineHumansatherosclerosis high-density lipoprotein cholesterol polycystic ovary syndrome small and dense low-density lipoprotein triglyceridesDyslipidemiasTriglyceridebusiness.industryCholesterolCholesterol HDLnutritional and metabolic diseasesObstetrics and Gynecology2729 Obstetrics and GynecologyCholesterol LDLmedicine.diseaseAtherosclerosisPrognosisPolycystic ovaryMetforminEndocrinologyTreatment OutcomechemistryCardiovascular Diseaseslipids (amino acids peptides and proteins)Drug Therapy CombinationFemaleControlled Clinical Trials as Topicmedicine.symptomHydroxymethylglutaryl-CoA Reductase InhibitorsbusinessPioglitazoneDyslipidemiamedicine.drugLipoproteinPolycystic Ovary Syndrome
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Atherogenic forms of dyslipidaemia in women with polycystic ovary syndrome.

2009

OBJECTIVE: Dyslipidaemia is very common in patients with polycystic ovary syndrome (PCOS) but, beyond plasma lipids, atherogenic lipoprotein (Lp) and apolipoprotein (apo) alterations are still ill defined. DESIGN: We measured concentrations of apoB, Lp(a) and small, dense low-density lipoprotein (LDL) in 42 patients with PCOS [age: 28 +/- 7 years, body mass index (BMI): 27 +/- 5 kg/m(2)] vs. 37 age- and BMI-matched healthy controls. METHODS: Elevated Lp(a) levels considered were those > 30 mg/dl while elevated apoB concentrations were those > 100 g/l. RESULTS: Polycystic ovary syndrome showed increased triglycerides levels (p = 0.0011) and lower high-density lipoprotein (HDL)-cholesterol co…

Adultmedicine.medical_specialtySettore MED/09 - Medicina InternaApolipoprotein B10265 Clinic for Endocrinology and Diabetology610 Medicine & health2700 General MedicineSettore MED/13 - EndocrinologiaBody Mass Indexchemistry.chemical_compoundYoung AdultRisk FactorsInternal medicinemedicinedyslipidemia lipoproteins polycystic ovary syndromeHumansProspective cohort studyApolipoproteins BDyslipidemiasbiologyCholesterolbusiness.industryVascular diseaseCase-control studynutritional and metabolic diseasesGeneral MedicineCholesterol LDLmedicine.diseasePolycystic ovaryEndocrinologychemistry10036 Medical ClinicCardiovascular DiseasesCase-Control Studiesbiology.proteinlipids (amino acids peptides and proteins)FemalebusinessBody mass indexLipoproteinLipoprotein(a)Polycystic Ovary SyndromeInternational journal of clinical practice
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Differences in dyslipidemia between American and Italian women with polycystic ovary syndrome.

2008

Abstract BACKGROUND: Dyslipidemia is a common metabolic complication in polycystic ovary syndrome (PCOS). The aim of this study was to determine if differences exist in dyslipidemia in women with PCOS from different ethnic and geographical backgrounds. METHODS: This retrospective study evaluated the serum fasting lipid profiles of 106 women with PCOS from the United States and 108 women with PCOS from Italy evaluated at endocrinology clinics. RESULTS: American women had higher mean body mass index than Italian women (36.1+/-8.6 vs 28.1+/-5.8 kg/m2, p<0.01). Low HDL-cholesterol was the most prevalent lipid abnormality in both populations. U.S. women had higher mean levels of serum total chol…

Adultmedicine.medical_specialtySettore MED/09 - Medicina InternaEndocrinology Diabetes and MetabolismEthnic groupPhysiologySettore MED/13 - EndocrinologiaBody Mass IndexCohort StudiesEndocrinologyRisk FactorsmedicinePrevalenceHumansObesityPCOS Hyperandrogenism Cardiovascular risk dyslipidemia LDL-cholesterolDyslipidemiasRetrospective StudiesGynecologybusiness.industryRetrospective cohort studyOverweightmedicine.diseaseObesityPolycystic ovarySettore MED/40 - Ginecologia E OstetriciaLipidsConfidence intervalUnited StatesItalyCardiovascular DiseasesFemalebusinessBody mass indexDyslipidemiaCohort studyPolycystic Ovary SyndromeJournal of endocrinological investigation
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Fluctuation of the left ventricular ejection fraction in patients with HER2-positive early breast cancer treated by 12 months of adjuvant trastuzumab.

2018

Abstract Background Cardiac toxicity with a decrease of the left ventricular ejection fraction (LVEF) is the main side effect induced by trastuzumab. This study reports the fluctuation of LVEF over the 12 months of adjuvant trastuzumab in PHARE trial (NCT00381901). Methods LVEF assessment was performed every 3 months while patients received trastuzumab and after completion of treatment over the first 2 years and then every 6 months afterwards. The fluctuations of LVEF over time were described and a logistic regression model was performed investigating associated factors to LVEF perfect recovery at baseline value. Results A total of 1631 patients who received 12 months of trastuzumab from PH…

Adultmedicine.medical_specialtySide effectReceptor ErbB-2medicine.medical_treatmentBreast Neoplasms030204 cardiovascular system & hematologyVentricular Function Left03 medical and health sciences0302 clinical medicineBreast cancerAntineoplastic Agents ImmunologicalTrastuzumabInternal medicinemedicineHumansIn patientcardiovascular diseasesCardiotoxicityEjection fractionbusiness.industryGeneral MedicineMiddle AgedTrastuzumabmedicine.diseaseCardiotoxicityStandard errorChemotherapy AdjuvantEchocardiography030220 oncology & carcinogenesiscardiovascular systemCardiologySurgeryFemalebusinessAdjuvantcirculatory and respiratory physiologymedicine.drugFollow-Up StudiesBreast (Edinburgh, Scotland)
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