Search results for "Case-Control Studies"

showing 10 items of 1567 documents

Diabetic and non-diabetic subjects with ischemic stroke: Differences, subtype distribution and outcome

2008

Abstract Background and aim Diabetes mellitus increases the risk of stroke, and pathophysiological changes of diabetic cerebral vessels may differ in comparison with non-diabetic ones; nonetheless, the clinical and prognostic profile of stroke in diabetic patients is not yet fully understood. On this basis, the aim of our study was to evaluate cerebrovascular risk factor prevalence in diabetic stroke patients in comparison with non-diabetics, to analyze whether diabetics have a different prevalence of stroke subtypes as classified by the TOAST classification, and determine whether diabetics and non-diabetics have a different prognosis. Methods and results We enrolled 102 diabetics and 204 n…

MaleTOAST ClassificationTime FactorsSettore MED/09 - Medicina InternaEndocrinology Diabetes and MetabolismMedicine (miscellaneous)Severity of Illness IndexBrain IschemiaRecurrenceRisk FactorsOdds RatioPrevalenceMedicineStrokeAged 80 and overNutrition and Dieteticsdiabetes mellituMiddle AgedPrognosisStrokeAcute DiseaseHypertensionCardiologyFemaleSettore MED/26 - NeurologiaCardiology and Cardiovascular Medicinemedicine.medical_specialtyLacunar strokeRisk AssessmentDiabetes ComplicationsTOAST classificationDiabetes mellitusInternal medicineSeverity of illnessischemic strokeHumanscardiovascular diseasesAgedbusiness.industryCase-control studyRecovery of FunctionOdds ratiomedicine.diseaseSSS*Logistic ModelsDiabetes Mellitus Type 2Case-Control StudiesPhysical therapyScandinavian Stroke ScalebusinessFollow-Up Studies
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Immuno-inflammatory activation in acute cardio-embolic strokes in comparison with other subtypes of ischaemic stroke

2009

Few studies have examined the relationship between inflammatory biomarker blood levels, cardioembolic stroke subtype and neurological deficit. So the aim of our study is to evaluate plasma levels of immuno-inflammatory variables in patients with cardio-embolic acute ischaemic stroke compared to other diagnostic subtypes and to evaluate the relationship between immuno-inflammatory variables, acute neurological deficit and brain infarct volume. One hundred twenty patients with acute ischaemic stroke and 123 controls without a diagnosis of acute ischaemic stroke were evaluated. The type of acute ischaemic stroke was classified according to the TOAST classification. We evaluated plasma levels o…

MaleTOAST Classificationmedicine.medical_specialtySettore MED/09 - Medicina InternaHeart DiseasesEmbolismInterleukin-1betaSeverity of Illness IndexBrain Ischemiacytokines stroke cardioembolicCentral nervous system diseaseBrain ischemiaDisability EvaluationPredictive Value of TestsInternal medicineSeverity of illnessmedicineHumanscardiovascular diseasesStrokeAgedAged 80 and overInterleukin-6Tumor Necrosis Factor-alphaVascular diseasebusiness.industryCerebral infarctionCase-control studyHematologyMiddle Agedmedicine.diseaseSurgeryStrokeRisk Factors inflammation cytokines Stroke Cerebral infarct cerebrovascular disease cerebrovascular accidentCase-Control StudiesLinear ModelsCardiologyFemaleSettore MED/26 - NeurologiaInflammation MediatorsbusinessBiomarkers
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Impact of periodontal treatment on the RANKL/OPG ratio in crevicular fluid.

2020

Aim Alveolar resorption is one of the most important events in periodontitis. Osteoclast activity is regulated by the ratio between receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG). The aim of this study was to evaluate changes in the RANKL/OPG ratio in crevicular fluid after periodontal treatment. Material and methods A total of 15 patients with periodontitis were included in the study group. Samples were collected from an area with active periodontitis and a healthy area. The RANKL and OPG levels were measured before and after periodontal scaling and root planing (SRP) treatment. The study group was compared to the control group, which included 10 patients without peri…

MaleTeethAlveolar Bone LossOsteoclastsPathology and Laboratory MedicineAntiplatelet TherapyVascular Medicine0302 clinical medicineScaling and root planingOral DiseasesAnimal CellsMedicine and Health SciencesProspective StudiesProspective cohort studyConnective Tissue CellsMultidisciplinarybiologyPharmaceuticsQRGingival Crevicular FluidMiddle AgedHealthy VolunteersTreatment Outcomemedicine.anatomical_structureConnective TissueRANKL030220 oncology & carcinogenesisMedicineFemaleAnatomyCellular TypesPeriodontal IndexResearch Articlemusculoskeletal diseasesmedicine.medical_specialtyScienceOral MedicineHemorrhage03 medical and health sciencesSigns and SymptomsDrug TherapyOsteoprotegerinDiagnostic MedicineOsteoclastInternal medicinemedicineHumansPeriodontitisBonePeriodontal DiseasesAgedPeriodontitisbusiness.industryRANK LigandOsteoprotegerinCase-control studyBiology and Life SciencesRANK LigandCell Biology030206 dentistrymedicine.diseaseBiological TissueEndocrinologyJawCase-Control StudiesChronic Periodontitisbiology.proteinDental ScalingbusinessDigestive SystemHeadPLoS ONE
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Dissociations and interactions between time, numerosity and space processing

2009

AbstractThis study investigated time, numerosity and space processing in a patient (CB) with a right hemisphere lesion. We tested whether these magnitude dimensions share a common magnitude system or whether they are processed by dimension-specific magnitude systems. Five experimental tasks were used: Tasks 1–3 assessed time and numerosity independently and time and numerosity jointly. Tasks 4 and 5 investigated space processing independently and space and numbers jointly. Patient CB was impaired at estimating time and at discriminating between temporal intervals, his errors being underestimations. In contrast, his ability to process numbers and space was normal. A unidirectional interactio…

MaleTime FactorsCognitive NeuroscienceMagnitude (mathematics)Experimental and Cognitive PsychologySpaceSpace (commercial competition)Neuropsychological Tests050105 experimental psychologyArticleTimeCorrelation03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineNumerosityHumans0501 psychology and cognitive sciencesArithmeticSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologica05 social sciencesInformation processingContrast (statistics)MagnitudeNumerosity adaptation effectCognitionInfarction Middle Cerebral ArteryMathematical ConceptsTime perceptionMiddle AgedNumber cognitionTime magnitude numerosity space number cognitionCase-Control StudiesSpace PerceptionTime PerceptionFemalePsychologyNeuroscience030217 neurology & neurosurgeryPsychomotor PerformanceNeuropsychologia
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Acute impact of an endurance race on cardiac function and biomarkers of myocardial injury in triathletes with and without myocardial fibrosis.

2019

Aims The aim of this study was to investigate the occurrence of myocardial injury and cardiac dysfunction after an endurance race by biomarkers and cardiac magnetic resonance in triathletes with and without myocardial fibrosis. Methods and results Thirty asymptomatic male triathletes (45 ± 10 years) with over 10 training hours per week and 55 ± 8 ml/kg per minute maximal oxygen uptake during exercise testing were studied before (baseline) and 2.4 ± 1.1 hours post-race. Baseline cardiac magnetic resonance included cine, T1/T2, late gadolinium enhancement (LGE) and extracellular volume imaging. Post-race non-contrast cardiac magnetic resonance included cine and T1/T2 mapping. Non-ischaemic my…

MaleTime FactorsEpidemiologyBlood Pressure030204 cardiovascular system & hematologyFull Research PaperVentricular Function LeftRunning0302 clinical medicineSports CardiologyCreatine Kinase MB FormAthlete's heartpost-race myocardial oedemaEdema CardiacEjection fractionTroponin TMiddle Agedddc:late gadolinium enhancementpost-race cardiac functionHypertensionCardiologyCardiology and Cardiovascular MedicineCardiomyopathiesCardiac function curveAdultmedicine.medical_specialtyAdolescentMagnetic Resonance Imaging Cinecardiac magnetic resonanceCardiac dysfunction03 medical and health sciencesYoung AdultLinear gingival erythemaTroponin TPredictive Value of TestsInternal medicinemedicineHumanscardiovascular diseasesExerciseSwimmingbusiness.industryMyocardiumT2 and T1 mapping030229 sport sciencesmedicine.diseaseFibrosisBicyclingBlood pressureAthletesCase-Control StudiesPhysical EnduranceVentricular Function RightMyocardial fibrosismyocardial fibrosisbusinessCardiac magnetic resonanceBiomarkersEuropean journal of preventive cardiology
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Autobiographical memory in Parkinson's disease: A retrieval deficit

2012

This study examined the effects of providing cues to facilitate autobiographical memory retrieval in Parkinson's disease. Previous findings have shown that individuals with Parkinson's disease retrieve fewer specific autobiographical memories than older adult controls. These findings are clinically significant since the quality of autobiographical memory is linked to identity and sense of self. In the current study, 16 older adults with Parkinson's disease without dementia and 16 matched older adult controls were given 3 min in which to recall autobiographical memories associated with five different time periods and to give each memory a short title. Participants were later asked to retriev…

MaleTime FactorsParkinson's diseaseRecallAutobiographical memoryMemory EpisodicCognitive NeuroscienceNeuropsychologyParkinson Diseasemedicine.diseaseBehavioral NeuroscienceNeuropsychology and Physiological PsychologyFree recallCase-Control StudiesMental RecallmedicineHumansDementiaFemaleChildhood memoryCuesPsychologyEpisodic memoryAgedCognitive psychologyJournal of Neuropsychology
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Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study

2013

AIM: In the context of the Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkin's Lymphoma (SETIL), the risk of childhood cancer was investigated in relation to parental occupational exposures. METHODS: All cases of childhood leukaemia and non-Hodgkin's lymphoma (NHL) in children aged 0-10 years were identified. Controls were chosen at random from the local population in each region. Parents were interviewed using a structured questionnaire. The collected data were blindly reviewed by expert industrial hygienists in order to estimate exposure to a list of agents. Statistical analyses were performed for each agent using unconditional multivariabl…

MaleToxicologyEconomicaPregnancyhemic and lymphatic diseasesEpidemiologyChildMultivariate Analysiparental exposureIncidenceLymphoma Non-HodgkinIncidence (epidemiology)Precursor Cell Lymphoblastic Leukemia-LymphomaOccupational exposureEpidemiologic StudieItalyMaternal ExposureChemical IndustryChild PreschoolPrenatal Exposure Delayed EffectsSolventPaternal ExposureFemaleSurvival AnalysiHYDROCARBONSCase-Control StudieRisk assessmentHumanmedicine.medical_specialtyLogistic ModelAdolescentSocio-culturaleContext (language use)Risk AssessmentPrenatal Exposure Delayed EffectHazardous SubstancesAge DistributionEnvironmental healthmedicineHumansSex DistributionSurvival analysisACUTE LYMPHOBLASTIC-LEUKEMIAbusiness.industryPublic Health Environmental and Occupational HealthCase-control studyAmbientalemedicine.diseaseSurvival AnalysisNon-Hodgkin's lymphomaEpidemiologic StudiesPaternal ExposureLogistic ModelssolventsHazardous SubstanceCase-Control StudiesMultivariate AnalysisbusinessOccupational and Environmental Medicine
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T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients.

2009

Summary There are increased numbers of activated T lymphocytes in the bronchial mucosa of stable chronic obstructive pulmonary disease (COPD) patients. T helper type 17 (Th17) cells release interleukin (IL)-17 as their effector cytokine under the control of IL-22 and IL-23. Furthermore, Th17 numbers are increased in some chronic inflammatory conditions. To investigate the expression of interleukin (IL)-17A, IL-17F, IL-21, IL-22 and IL-23 and of retinoic orphan receptor RORC2, a marker of Th17 cells, in bronchial biopsies from patients with stable COPD of different severity compared with age-matched control subjects. The expression of IL-17A, IL-17F, IL-21, IL-22, IL-23 and RORC2 was measure…

MaleTranslational StudiesReceptors Retinoic Acidmedicine.medical_treatmentImmunologyautoimmunity bronchial biopsies emphysema neutrophilsInflammationBronchiInterleukin-23Polymerase Chain ReactionStatistics NonparametricPulmonary Disease Chronic ObstructiveAutoimmunity bronchial biopsies emphysema neutrophils pathologymedicineInterleukin 23Immunology and AllergyHumansRNA MessengerAgedDNA PrimersCOPDAnalysis of VarianceMucous MembraneReceptors Thyroid Hormonebusiness.industryInterleukinsRespiratory diseaseInterleukin-17SmokingInterleukinT-Lymphocytes Helper-InducerMiddle AgedNuclear Receptor Subfamily 1 Group F Member 3medicine.diseaseImmunohistochemistryrespiratory tract diseasesRespiratory Function TestsCytokineCase-Control StudiesImmunologyFemaleInterleukin 17medicine.symptombusinessCD8
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Umbilical cord blood transplantation from unrelated donors in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

2014

Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; There are very few disease-specific studies focusing on outcomes of umbilical cord blood transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. We report the outcome of 45 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who underwent myeloablative single unit cord blood transplantation from unrelated donors within the GETH/GITMO cooperative group. Conditioning regimens were based on combinations of thiotepa, busulfan, cyclophospamide or fludarabine, and antithymocyte globulin. At the time of transplantation, 35 patients (78%) were in first complete remission, four (8%) …

MaleTransplantation Conditioning:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings]Leucemia-linfoma linfoblástico de células precursorasGraft vs Host Disease:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Supervivencia sin EnfermedadGastroenterology:Anatomy::Body Regions::Transplants::Allografts [Medical Subject Headings]:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents::Myeloablative Agonists [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]hemic and lymphatic diseasesMedicineCumulative incidenceTasa de SupervivenciaPhiladelphia ChromosomeChildCromosoma Filadelfia:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child::Child Preschool [Medical Subject Headings]ArticlesHematologyMiddle AgedPrecursor Cell Lymphoblastic Leukemia-LymphomaAllografts:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunosuppression::Transplantation Conditioning [Medical Subject Headings]FludarabineSurvival RateChild Preschool:Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings]:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Chromosome Aberrations::Translocation Genetic::Philadelphia Chromosome [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis::Disease-Free Survival [Medical Subject Headings]FemaleAcondicionamiento para el trasplanteCord Blood Stem Cell TransplantationTrasplante de células madre de la sangre del cordónmedicine.drugAloinjertosAdultmedicine.medical_specialtyAdolescent:Check Tags::Male [Medical Subject Headings]Cord Blood Stem Cell TransplantationPhiladelphia chromosomeEnfermedad injerto contra huéspedDisease-Free SurvivalEstudios retrospectivosInternal medicine:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings]:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]HumansPreschoolSurvival rate:Named Groups::Persons::Age Groups::Child [Medical Subject Headings]Retrospective Studies:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Survival Rate [Medical Subject Headings]business.industryUmbilical Cord Blood TransplantationEnfermedad crónicaAgonistas mieloablativosMyeloablative Agonistsmedicine.diseaseSettore MED/15SurgeryTransplantation:Diseases::Immune System Diseases::Graft vs Host Disease [Medical Subject Headings]:Diseases::Hemic and Lymphatic Diseases::Lymphatic Diseases::Lymphoproliferative Disorders::Leukemia Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma [Medical Subject Headings]:Check Tags::Female [Medical Subject Headings]Estudios de SeguimientoChronic Disease:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Cord Blood Stem Cell Transplantation [Medical Subject Headings]Adolescent; Adult; Allografts; Child; Child Preschool; Chronic Disease; Disease-Free Survival; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Male; Middle Aged; Myeloablative Agonists; Retrospective Studies; Survival Rate; Cord Blood Stem Cell Transplantation; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation ConditioningbusinessBusulfanFollow-Up Studies
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Effects of anti-cardiolipin antibodies and IVIg on annexin A5 binding to endothelial cells: implications for cardiovascular disease

2010

Anti-phospholipid antibodies (aPL), including anti-cardiolipin antibodies (aCL), are risk factors for cardiovascular disease (CVD) in the general population and in patients with the anti-phospholipid syndrome (APS; Hughes syndrome). APS may be primary but is also common in patients with systemic lupus erythematosus (SLE). The anti-coagulant protein annexin A5 (ANXA5) is implicated in CVD by interfering with phospholipids and aPL.ANXA5 binding to human umbilical venous endothelial cells (HUVECs) was determined by flow cytometry.When cells were cultured in serum from APS patients with a high aPL titre (aPL-S), binding of ANXA5 to HUVECs was reduced. Monoclonal immunoglobulin (Ig)G aPL against…

MaleUmbilical Veinsmedicine.medical_specialtyEndotheliumPopulationImmunologyImmunoglobulin Gchemistry.chemical_compoundRheumatologyReference Valuesimmune system diseasesAntiphospholipid syndromeInternal medicineCardiolipinmedicineHumansImmunology and AllergyAnnexin A5educationneoplasmsCells CulturedProbabilityeducation.field_of_studyBinding Sitesbiologybusiness.industryEndothelial CellsImmunoglobulins IntravenousGeneral MedicineAntiphospholipid SyndromeFlow Cytometrymedicine.diseaseEndocrinologymedicine.anatomical_structurechemistryCardiovascular DiseasesAntibodies AnticardiolipinCase-Control StudiesImmunoglobulin Gbiology.proteinFemaleAnti-cardiolipin antibodiesAntibodyAnnexin A5businessScandinavian Journal of Rheumatology
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