Search results for "Cases"

Oxidative stress and antioxidant response in fibroblasts from Werner and Atypical Werner Syndromes

2014

Werner Syndrome (WS, ICD-10 E34.8, ORPHA902) and Atypical Werner Syndrome (AWS, ICD-10 E34.8, ORPHA79474) are very rare inherited syndromes characterized by premature aging. While approximately 90% of WS individuals have any of a range of mutations in theWRN gene, there exists a clinical subgroup in which the mutation occurs in the LMNA/C gene in heterozygosity. Although both syndromes exhibit an age-related pleiotropic phenotype, AWS manifests the onset of the disease during childhood, while major symptoms in WS appear between the ages of 20 and 30. To study the molecular mechanisms of progeroid diseases provides a useful insight into the normal aging process. Main changes found were the d…

Repair of oxidatively generated DNA damage in Cockayne syndrome

2013

Defects in the repair of endogenously (especially oxidatively) generated DNA modifications and the resulting genetic instability can potentially explain the clinical symptoms of Cockayne syndrome (CS), a hereditary disease characterized by developmental defects and neurological degeneration. In this review, we describe the evidence for the involvement of CSA and CSB proteins, which are mutated in most of the CS patients, in the repair and processing of DNA damage induced by reactive oxygen species and the implications for the induction of cell death and mutations. Taken together, the data demonstrate that CSA and CSB, in addition to their established role in transcription-coupled nucleotide…

Alla ricerca dei fattori rilevanti nell’adozione dei sistemi di gestione della performance nelle amministrazioni pubbliche territoriali. L’analisi di…

2013

La ricerca scientifica ha dimostrato che la gestione della performance nelle amministrazioni pubbliche sta oggi spostando il proprio focus dalla mera attività di raccolta e rendicontazione di dati alla generazione di informazioni atte a supportare la formulazione di decisioni. L’analisi comparativa dei casi di studio analizzati in questo articolo mira ad identificare i fattori critici sottostanti alla progettazione e all’utilizzo dei sistemi di gestione della performance nelle amministrazioni regionali. Da questa analisi emerge che alcune variabili risultano essenziali ai fini di un’efficace adozione dei sistemi di performance management. Tra queste variabili sono annoverabili: il ruolo del…

Senataxin defective in ataxia oculomotor apraxia type 2 is involved in the defence against oxidative DNA damage

2007

Adefective response to DNA damage is observed in several human autosomal recessive ataxias with oculomotor apraxia, including ataxia-telangiectasia. We report that senataxin, defective in ataxia oculomotor apraxia (AOA) type 2, is a nuclear protein involved in the DNA damage response. AOA2 cells are sensitive to H2O2, camptothecin, and mitomycin C, but not to ionizing radiation, and sensitivity was rescued with full-length SETX cDNA. AOA2 cells exhibited constitutive oxidative DNA damage and enhanced chromosomal instability in response to H2O2. Rejoining of H2O2-induced DNA double-strand breaks (DSBs) was significantly reduced in AOA2 cells compared to controls, and there was no evidence fo…

Regulation of human inducible nitric oxide synthase expression by an upstream open reading frame.

2019

Abstract The human inducible nitric oxide synthase (iNOS) gene contains an upstream open reading frame (uORF) in its 5′-untranslated region (5′-UTR) implying a translational regulation of iNOS expression. Transfection experiments in human DLD-1 cells revealed that the uORF although translatable seems not to inhibit the translation start at the bona fide ATG. Our data clearly show that human iNOS translation is cap-dependent and that the 5′-UTR of the iNOS mRNA contains no internal ribosome entry site. Translation of the bona fide coding sequence is most likely mediated by a leaky scanning mechanism. The 5′-UTR is encoded by exon 1 and exon 2 of the iNOS gene with the uORF stop codon located…

[Ordenanza, 1817-03-08]

Ordinacions fetes per Pere terç, rey d'Aragó

Ms Títol obtingut de la rúbrica (f. 1r) Col·lació: Paper, f. 5 (paper) + 184 (1 f. original sense numerar) + 4 (paper) ; foliació original amb numeració romana ; reclams horitzontals als f. 14v, 28v, 48v, 72v, 98v, 138v, 170v i 128v, manquen al f. 118v, 154v i 142v ; signatures de quadern als f. 15r, 29r, 73r, 119v, 155r, 171r i 183r, manquen les corresponens als quaderns que comencen als f. 1r, 49r, 99r i 139r Composició: Escrit a línia tirada Escriptura: Gòtica cursiva. Anotacions marginals de diverses mans entre les quals es pot identificar l'autògrafa del rei Pere el Cerimoniós i la de Pere Miquel Carbonell, arxiver reial Decoració: Caplletres en blau i roig i rúbriques en tinta vermell…

Space (Cases)

2014

De Montaigne a Lope: distintos resultados de una misma decisión

2009

This essay presents the initial hypothesis of the diversity of cases shown by Lope de Vega’s theatre, that multiply perspectives and different endings from the same basic types of conflicts and designs, and tries to verify them with contemporary thought. This diversity is related with a certain type of discourse that has begun to spread out in the very beginning of the Renaissance and was gradually displacing the pre-eminence of universal principles (neo-platonic, or neoaristotelic and scholastic) for an invitation to casuistic analysis, an ethical modality applied that chose the concrete analysis of the concrete situation in front of the universally required dogmas. A type of discourse tha…

Cytosolic RIG-I–like helicases act as negative regulators of sterile inflammation in the CNS

2011

The action of cytosolic RIG-I-like helicases (RLHs) in the CNS during autoimmunity is largely unknown. Using a mouse model of multiple sclerosis, we found that mice lacking the RLH adaptor IPS-1 developed exacerbated disease that was accompanied by markedly higher inflammation, increased axonal damage and elevated demyelination with increased encephalitogenic immune responses. Furthermore, activation of RLH ligands such as 5'-triphosphate RNA oligonucleotides decreased CNS inflammation and improved clinical signs of disease. RLH stimulation repressed the maintenance and expansion of committed T(H)1 and T(H)17 cells, whereas T-cell differentiation was not altered. Notably, T(H)1 and T(H)17 s…