Search results for "Cases"
showing 10 items of 124 documents
The elemental role of iron in DNA synthesis and repair
2017
Iron is an essential redox element that functions as a cofactor in many metabolic pathways. Critical enzymes in DNA metabolism, including multiple DNA repair enzymes (helicases, nucleases, glycosylases, demethylases) and ribonucleotide reductase, use iron as an indispensable cofactor to function. Recent striking results have revealed that the catalytic subunit of DNA polymerases also contains conserved cysteine-rich motifs that bind iron–sulfur (Fe/S) clusters that are essential for the formation of stable and active complexes. In line with this, mitochondrial and cytoplasmic defects in Fe/S cluster biogenesis and insertion into the nuclear iron-requiring enzymes involved in DNA synthesis a…
“Curious Victories”: The Famous Murder Case of Maria Barbella and Italian-American Women in the Press Between the 1890s and 1910s
2019
Immigrant women during the period of mass migration received little public attention. However, when some of them became protagonists in sensational murder cases, they burst into the public sphere. Analyzing the representation of Maria Barbella's trial in the mainstream, yellow and the Italian-American press shows how some of these invisible women were able to assert themselves in the public sphere and achieve a degree of agency despite their tragic circumstances. These women, represented as degenerate and genetically inferior in the early coverage of their cases and trials, were, over time, essentially rehabilitated in the press as “proper” American subjects as a result of the convergence o…
DELL’UTRI E CONTRADA “GEMELLI DIVERSI”: È LA REVISIONE EUROPEA LO STRUMENTO DI OTTEMPERANZA ALLE SENTENZE CEDU
2017
La Cassazione nega l’origine giurisprudenziale del concorso esterno in associazione mafiosa e individua il rimedio della revisione europea per l’attuazione della decisione CEDU nei confronti di soggetti in posizioni simili a quella di Contrada. Il percorso offre l’occasione per riflettere sulla connotazione “oggettiva” della prevedibilità e sull’uguaglianza di trattamento dei condannati. Italian supreme Court denies that the origin of external participation in mafia-type criminal association lies in case law and envisages the European review as the tool to comply with ECtHR judgements in similar cases to that of Contrada. This jurisprudence provides a proper opportunity for an in-depth exam…
Identifying opportunities for AI applications in healthcare — Renewing the national healthcare and social services
2018
A vast variety of artificial intelligence techniques have been deployed to specific healthcare problems during the last thirty years with varying levels of success while there is a shortage of systematic matching of AI capabilities with the breadth of application opportunities. In this paper, we describe the process of identifying opportunities for deploying artificial intelligence to healthcare and social services on regional and national levels in Finland. The project involved a large number of stakeholders from a variety of backgrounds ranging from governmental agencies to entrepreneurs. The process described includes idea generation of an application or solution and its elaboration in w…
Lexical verbs in a medical case-report wordlist
2018
Clinical case reports or clinical cases (CRs) are, perhaps, the most widely read text type in medicine, since they contain a detailed description of the patient’s medical history and symptoms and thus furnish ample teaching material for physicians-in-training. For non-native speakers of English in medicine, autonomous learning is often restricted because of a lack of medical lexicon, poor academic vocabulary, and weak lexical verb use. Here, we present the results of an investigation of lexical verbs: their distribution, classification, and contextual use in the different sections of the genre CRs. We suggest that lexical verbs with contextual use should be included in medical dictionaries …
Expression inactivation of SMARCA4 by microRNAs in lung tumors
2014
SMARCA4 is the catalytic subunit of the SWI/SNF chromatin-remodeling complex, which alters the interactions between DNA and histones and modifies the availability of the DNA for transcription. The latest deep sequencing of tumor genomes has reinforced the important and ubiquitous tumor suppressor role of the SWI/SNF complex in cancer. However, although SWI/SNF complex plays a key role in gene expression, the regulation of this complex itself is poorly understood. Significantly, an understanding of the regulation of SMARCA4 expression has gained in importance due to recent proposals incorporating it in therapeutic strategies that use synthetic lethal interactions between SMARCA4-MAX and SMAR…
Neuroblastoma after Childhood: Prognostic Relevance of Segmental Chromosome Aberrations, ATRX Protein Status, and Immune Cell Infiltration
2014
AbstractNeuroblastoma (NB) is a common malignancy in children but rarely occurs during adolescence or adulthood. This subgroup is characterized by an indolent disease course, almost uniformly fatal, yet little is known about the biologic characteristics. The aim of this study was to identify differential features regarding DNA copy number alterations, α-thalassemia/mental retardation syndrome X-linked (ATRX) protein expression, and the presence of tumor-associated inflammatory cells. Thirty-one NB patients older than 10 years who were included in the Spanish NB Registry were considered for the current study; seven young and middle-aged adult patients (range 18-60 years) formed part of the c…
The Drosophila Cystoblast Differentiation Factor, benign gonial cell neoplasm, Is Related to DExH-box Proteins and Interacts Genetically With bag-of-…
2000
Abstract Selection of asymmetric cell fates can involve both intrinsic and extrinsic factors. Previously we have identified the bag-of-marbles (bam) gene as an intrinsic factor for cystoblast fate in Drosophila germline cells and shown that it requires active product from the benign gonial cell neoplasm (bgcn) gene. Here we present the cloning and characterization of bgcn. The predicted Bgcn protein is related to the DExH-box family of RNA-dependent helicases but lacks critical residues for ATPase and helicase functions. Expression of the bgcn gene is extremely limited in ovaries but, significantly, bgcn mRNA is expressed in a very limited number of germline cells, including the stem cells.…
Nutritional self-care in two older Norwegian males: a case study
2013
Solveig T Tomstad,1,2 Ulrika Söderhamn,2 Geir Arild Espnes,1,3 Olle Söderhamn21Department of Social Work and Health Science, Faculty of Social Sciences and Technology Management, Norwegian University of Science and Technology, Trondheim, 2Centre for Caring Research-Southern Norway, Faculty of Health and Sport Sciences, University of Agder, Grimstad, 3Research Centre for Health Promotion and Resources, Department of Social Work and Health Science, Faculty of Social Sciences and Technology Management, Norwegian University of Science and Technology, Trondheim, NorwayBackground: Knowledge about how to support nutritional self-care in the vulnerable elderly living in their own …
Dicer and drosha expression and response to bevacizumab-based therapy in advanced colorectal cancer patients.
2013
PURPOSE: The miRNA-regulating enzymes Dicer and Drosha exhibit aberrant expression in several cancer types. Dicer and Drosha play a crucial role during the angiogenetic process in vitro and, for Dicer, in vivo. We aimed to investigate the potential role of Dicer and Drosha in predicting response to Bevacizumab-based therapy in advanced colorectal cancer (CRC) patients. METHODS: Dicer and Drosha mRNA levels were analysed in formalin-fixed paraffin-embedded specimens from patients affected by advanced CRC treated with or without Bevacizumab-containing regimens (n=116 and n=50, respectively) and from patients with diverticulosis as control group (n=20). The experimental data were obtained usin…