Search results for "Catechol"

showing 10 items of 230 documents

The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control st…

2015

Background Abdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective of this work was to investigate whether the interaction between antioxidant vitamin intake and OS-related polymorphisms modulates gene-associated anthropometry in a Spanish population. Methods A total of 246 subjects with AO, and 492 age and gender matched non-AO subjects were included in the study. Anthropometric, biochemical, and OS parameters, and antioxidant dietary intake data were assessed using validated procedures. DNA from white blood cells was isolated and the genotype of seven polymorphisms from genes involved in …

MaleAntioxidantPolimorphismmedicine.medical_treatment:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Thioredoxins [Medical Subject Headings]Antioxidantes:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]AntioxidantsVitamin E intakeObesidad abdominalchemistry.chemical_compoundNutrigenomicsThioredoxinsPolymorphism (computer science):Anatomy::Cells::Blood Cells::Leukocytes [Medical Subject Headings]Risk FactorsGenotypeVitamin E:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleosides::Deoxyribonucleosides::Deoxyguanosine [Medical Subject Headings]:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::Micronutrients::Vitamins [Medical Subject Headings]:Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress [Medical Subject Headings]Abdominal obesityNutrigenómicaMedicine(all)AnthropometryAge FactorsGeneral MedicineAbdominal obesity:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity::Obesity Abdominal [Medical Subject Headings]Middle Aged:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models Statistical::Logistic Models [Medical Subject Headings]Waist circumferenceDietaFemale:Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]medicine.symptomFactores de riesgoVitaminAdultmedicine.medical_specialtyGenotypeVitamina ECatechol-O-methyltransferaseBiology:Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes Reporter [Medical Subject Headings]Catechol O-Methyltransferase:Chemicals and Drugs::Biological Factors::Pigments Biological::Carotenoids::Retinoids::Vitamin A [Medical Subject Headings]Polymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologySex FactorsInternal medicine:Chemicals and Drugs::Inorganic Chemicals::Oxygen Compounds::Reactive Oxygen Species [Medical Subject Headings]:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Antioxidants [Medical Subject Headings]medicinePerímetro abdominal:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Waist Circumference [Medical Subject Headings]:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 2-Ring::Benzopyrans::Vitamin E [Medical Subject Headings]HumansObesityPolymorphismThioredoxinAgedCatechol-O-methyl transferaseBiochemistry Genetics and Molecular Biology(all)Vitamin EResearchCase-control studyGenes informadores:Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics::Nutrigenomics [Medical Subject Headings]DietOxidative StressEndocrinologychemistrySpainOxidative stressCase-Control Studies:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::One-Carbon Group Transferases::Methyltransferases::Catechol O-Methyltransferase [Medical Subject Headings]:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::DNA [Medical Subject Headings]Genotipo
researchProduct

Multi-step metabolic activation of benzene. Effect of superoxide dismutase on covalent binding to microsomal macromolecules, and identification of gl…

1980

Abstract Incubation of [ 14 C]benzene or [ 14 C]phenol with liver microsomes from untreated rats, in the presence of a NADPH-generating system, gave rise to irreversible binding of metabolites to microsomal macromolecules. For both substrates this binding was inhibited by more than 50% by addition of superoxide dismutase to the incubation mixtures. The decrease in binding was compensated for by accumulation of [ 14 C]hydroquinone, indicating superoxide-mediated oxidation of hydroquinone as one step in the activation of benzene to metabolites binding to microsomal macromolecules. Since our previous work had shown that binding occurred mainly with protein rather than ribonucleic acid and was …

MaleMacromolecular SubstancesMetaboliteIn Vitro TechniquesToxicologyMass SpectrometryAdductchemistry.chemical_compoundPhenolsAnimalsPhenolBenzeneBiotransformationChromatography High Pressure LiquidCatecholChromatographyHydroquinoneSuperoxide DismutaseChemistryBenzeneGeneral MedicineGlutathioneGlutathioneBenzoquinoneRatsMicrosomes LiverChemico-Biological Interactions
researchProduct

Induction of brain CYP2E1 changes the effects of ethanol on dopamine release in nucleus accumbens shell.

2009

CYP2E1 is an important enzyme involved in the brain metabolism of ethanol that can be induced by chronic consumption of alcohol. Recent works have highlighted the importance of this system in the context of the behavioural effects of ethanol. Unfortunately, the underlying neurochemical events for these behavioural changes, has not been yet explored. In this work, we have started this exploration by analyzing the possible changes in the neurochemical response of the mesolimbic system to ethanol after pharmacological induction of brain CYP2E1. We have used the dopamine extracellular levels in nucleus accumbens (NAc) core and shell, measured by means of microdialysis in vivo, as an index of th…

MaleMicrodialysisDopamineContext (language use)Nucleus accumbensPharmacologyToxicologyNucleus Accumbenschemistry.chemical_compoundNeurochemicalDopaminemedicineAnimalsPharmacology (medical)Rats WistarNeurotransmitterInfusions IntravenousPharmacologyEthanolEthanolBrainCytochrome P-450 CYP2E1RatsPsychiatry and Mental healthchemistryEnzyme InductionCatecholamineNeurosciencemedicine.drugDrug and alcohol dependence
researchProduct

Local salsolinol modulates dopamine extracellular levels from rat nucleus accumbens: shell/core differences.

2008

Salsolinol (SAL), a condensation product of dopamine and acetaldehyde that appears in the rat and human brain after ethanol ingestion, has been largely implicated in the aetiology of alcoholism. Although the behavioural consequences of systemic or intracerebral SAL administrations have been described, the neurochemical effects of pharmacologically relevant doses of SAL and other tetrahydroisoquinolines (THIQs) in the brain areas involved in alcohol addiction are practically unknown. To gain an insight into this topic, male Wistar rats were stereotaxically implanted with one concentric microdialysis probe in either the shell or the core of the nucleus accumbens (NAc). Treatments involved loc…

MaleMicrodialysisDopamineMicrodialysisDown-RegulationAcetaldehydePharmacologyNucleus accumbensSynaptic TransmissionNucleus AccumbensCellular and Molecular Neurosciencechemistry.chemical_compoundNeurochemicalAlcohol-Induced Disorders Nervous SystemRewardDopamineparasitic diseasesBasal gangliamedicineAnimalsEthanol metabolismRats WistarNeurotransmitterChromatography High Pressure LiquidDose-Response Relationship DrugEthanolChemistryExtracellular FluidCell BiologyIsoquinolinesRatsUp-RegulationAlcoholismCatecholamineNeurosciencemedicine.drugNeurochemistry international
researchProduct

Influence of the amount of food ingested on mesolimbic dopaminergic system activity: a microdialysis study.

1996

Abstract The mesolimbic dopaminergic system (MDS) has been shown to be activated by ingestive behaviors, and it has been suggested that this activation may be related to the rewarding properties of foods. Because rats eat more when given a more palatable diet, this study was undertaken to determine the relationship between the amount of food ingested and DA release in the nucleus accumbens of freely moving rats. The extracellular levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured by high-performance liquid chromatography with electrochemical detection on microdialysis samples from the nucleus accumbens. Each rat underwent three microdia…

MaleMicrodialysismedicine.medical_specialtyDopamineMicrodialysisClinical BiochemistryNucleus accumbensBiologyToxicologyBiochemistryNucleus AccumbensRats Sprague-DawleyBehavioral Neurosciencechemistry.chemical_compoundEatingDopamineInternal medicinemedicineLimbic SystemAnimalsPalatabilityBiological PsychiatryPharmacologydigestive oral and skin physiologyHomovanillic acidDopaminergicHomovanillic Acidmedicine.diseaseRatsEndocrinologychemistryCatecholamine34-Dihydroxyphenylacetic AcidExtracellular SpaceIngestive behaviorsmedicine.drugPharmacology, biochemistry, and behavior
researchProduct

Toxicity of 5- chloro- 3- methyl- catechol to rat: Chemical observations and light microscopy of the tissue

1979

5-chloro-3-methyl-catechol was first time described by GAUNT and EVANS (1961) as a metabolite of MCPA (4-chloro-2-methylphenoxyacetic aci~which is the most widely used herbicide in the Nordic countries. The toxicity of the metabolite 5-chloro-3-methylcatechol bas hot been studied so far. Other catechols like 3,5dichlorocatechol has been shown to be a metabollte of 2,4-D (BOLLAG et ai. 1968a, BOLLAG et ai. 1968b), and it has been proven to be toxic to cells by HORVATH (1971). The catechols are metabolized by bacteria finally to muconic semialdehyde (HORVATH 1970, HORVATH and ALEXANDER 1970). In this work the toxicity of 5-chloro-3-methyl-catechol to maie rats was studied in acute and subchro…

MaleMicroscopyCatecholMethyl CatecholbiologyHealth Toxicology and MutagenesisMetaboliteCatecholsGeneral MedicineToxicologybiology.organism_classificationPollutionMCPAQuantitative determinationRatsLethal Dose 50Residue (chemistry)chemistry.chemical_compoundchemistryBiochemistryToxicityAnimalsBacteriaBulletin of Environmental Contamination and Toxicology
researchProduct

Ante-, peri- and postnatal factors associated with intraventricular hemorrhage in very premature infants.

2017

Intraventricular hemorrhage (IVH) is one of the most serious complications in preterm infants and is associated with neurological sequelae and mortality. Over the past few decades, the rate of IVH has decreased due to improved neonatal intensive care. However, up to 15-25% of very and extremely premature infants (32 and28weeks of pregnancy (WOP) respectively) still suffer from IVH.The aim of this study was to perform an updated, multicenter analysis to identify ante-, peri, and postnatal factors other than gestational age/birth weight associated with IVH of any grade in a large cohort of very and extremely premature infants.We performed a retrospective analysis in a prospectively conducted …

MalePediatricsmedicine.medical_specialtyBirth weightInfant Premature DiseasesAntenatal steroid03 medical and health sciences0302 clinical medicineCatecholaminesPre-EclampsiaPregnancyRisk Factors030225 pediatricsIntensive caremedicineHumansInfant Very Low Birth WeightPregnancy Complications InfectiousCerebral HemorrhageRetrospective StudiesUnivariate analysisbusiness.industryCesarean SectionObstetrics and GynecologyGestational agemedicine.diseaseRespiration ArtificialIntraventricular hemorrhageInfant Extremely PrematurePediatrics Perinatology and Child HealthCohortFemalebusiness030217 neurology & neurosurgeryCohort studyEarly human development
researchProduct

Effect of Haemodynamic Changes on Epithelium-related Intestinal Injury in Off-pump Coronary Surgery

2014

Intestinal injury is thought to play a central role in the occurrence of multiorgan dysfunction after on-pump coronary surgery. Clinical benefits of off-pump revascularisation remain, however, controversial.Hepatic enzymes and plasmatic IL-6, IL-8 and intestinal-type fatty acid binding protein (I-FABP) were determined in 20 patients (age 65-75) undergoing either on-pump (n = 10) or off-pump (n = 10) coronary surgery. Haemodynamic and biochemical parameters, catecholamine and volume therapy were monitored.Central venous pressure (CVP) was significantly higher in the off-pump group during and 12h after operation (9.5 ± 1.35 vs. 6.21 ± 0.63 mmH2O, p = 0.012). Higher GGT and GLDH levels occurre…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtyEnterocyteMedizinCoronary Artery Bypass Off-PumpHemodynamicsInflammationFatty Acid-Binding ProteinsGastroenterologyIntestinal mucosaInternal medicinemedicineHumansIntestinal MucosaGamma-glutamyltransferaseInterleukin 6AgedbiologyInterleukin-6business.industryInterleukin-8HemodynamicsCentral venous pressuregamma-GlutamyltransferaseIntestinal Diseasesmedicine.anatomical_structureAnesthesiaCatecholaminebiology.proteinFemalemedicine.symptomCardiology and Cardiovascular Medicinebusinessmedicine.drugHeart, Lung and Circulation
researchProduct

Risk stratification of normotensive pulmonary embolism: prognostic impact of copeptin

2015

The prognostic value of copeptin, the C-terminal fragment of the precursor protein of vasopressin which is released upon stress, and hypotension in pulmonary embolism is unknown, especially if combined with biomarkers reflecting different pathophysiological axes such as myocardial injury (high-sensitivity troponin T (hsTnT)) and stretch (N-terminal pro-brain natriuretic peptide (NT-proBNP)).We prospectively studied 268 normotensive pulmonary embolism patients included in a single-centre cohort study.Patients with an adverse 30-day outcome (5.6%) had higher copeptin levels than patients with a favourable course (median (interquartile range) 51.8 (21.6–90.8) versus 13.2 (5.9–39.3) pmol·L−1; p…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtymedicine.drug_classVentricular Dysfunction Right030204 cardiovascular system & hematologyRisk AssessmentCohort Studies03 medical and health sciencesCatecholamines0302 clinical medicineCopeptinTroponin TInterquartile rangeInternal medicineNatriuretic Peptide BrainmedicineNatriuretic peptideHumansProspective StudiesProspective cohort studyAgedTroponin Tbusiness.industryGlycopeptidesMiddle AgedPrognosismedicine.diseaseRespiration ArtificialCardiopulmonary ResuscitationPeptide Fragments3. Good healthPulmonary embolism030228 respiratory systemCardiologyFemalePulmonary EmbolismRisk assessmentbusinessBiomarkersCohort studyEuropean Respiratory Journal
researchProduct

The mutagenicity of MCPA and its soil metabolites, chlorinated phenols, catechols and some widely used slimicides in Finland

1977

MaleSalmonella typhimuriumChemistryHealth Toxicology and MutagenesisCatecholsGeneral Medicine2-Methyl-4-chlorophenoxyacetic AcidIn Vitro TechniquesToxicologyPollutionMCPAGlycolatesRatschemistry.chemical_compoundLiverChlorinated phenolsEnvironmental chemistryAnimalsEcotoxicologyOrganic chemistryPesticidesChlorophenolsMutagensBulletin of Environmental Contamination and Toxicology
researchProduct