Search results for "Causative"

showing 7 items of 17 documents

Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix[5]arene

2013

Cholera toxin (CT), the causative agent of cholera, displays a pentavalent binding domain that targets the oligosaccharide of ganglioside GM1 (GM1os) on the periphery of human abdominal epithelial cells. Here, we report the first GM1os-based CT inhibitor that matches the valency of the CT binding domain (CTB). This pentavalent inhibitor contains five GM1os moieties linked to a calix[5]arene scaffold. When evaluated by an inhibition assay, it achieved a picomolar inhibition potency (IC50 = 450 pM) for CTB. This represents a significant multivalency effect, with a relative inhibitory potency of 100000 compared to a monovalent GM1os derivative, making GM1os-calix[5]arene one of the most potent…

Models MolecularCholera ToxinbindingStereochemistrydesignCalix[5]areneEpithelial cellsG(M1) GangliosideHeat-labile enterotoxinmedicine.disease_causeligandBiochemistrycrystalMultivalency effectsCholeraCausative agentsmedicinePotencyHumansoligosaccharidePhysical and Theoretical ChemistryIC50Vibrio choleraeheat-labile enterotoxinVLAGchemistry.chemical_classificationgm1 mimicsGangliosideInhibition assaysChemistryCholera toxinOrganic ChemistryOligosaccharideBinding domainLigand (biochemistry)ValenciesOrganische ChemiehexamethylenetetramineChemistryPositive ionsaffinityAntitoxinsCalixarenesrecognitionBinding domain
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Meaning Extraction from Strappare Causatives in Italian

2021

The work targets a little-known causative construction of Italian whose causative verb is strappare ‘tear/extort/snatch’ (e.g. Ada strappò la confessione a Piero ‘Ada made Piero confess against his will’). In the active voice of this clause type, the subject, licensed by strappare, is invariably associated with the semantic role ‘Causer’ (as fare does in fare causatives, see [1]), whilst the post-verbal NP (e.g. confessione ‘confession’) is best analyzed as the predicate licensing the remaining syntactic function/s and the related semantic role/s. The NooJ grammar which the authors propose automatically extracts the meaning of strappare causatives by means of a novel type of semantic role. …

NooJCausative constructions; NooJ; NooJ local grammars; Predicate nouns; Semantic role labelingNooJ local grammarsSemantic role labelingCausative constructions Predicate nouns Semantic role labeling NooJ local grammarsCausative constructionsPredicate nounsSettore L-LIN/01 - Glottologia E Linguistica
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Biproportional methods of structural change analysis: A typological survey

2004

International audience; Analysts often are interested in learning how much an exchange system has changed over time or how two different exchange systems differ. Identifying structural difference in exchange matrices can be performed using either 'directed' or 'undirected' methods. Directed methods are based on the computation and comparison of column- or row-normalizations of the matrices. The choice of row or column for the normalization implies a specific direction of the exchanges, so that the column-wise normalized results should not be compared to the row-wise normalized results. In this category fall the simple comparison of coefficient matrices and the causative method. Undirected m…

Normalization (statistics)JEL : C - Mathematical and Quantitative Methods/C.C6 - Mathematical Methods • Programming Models • Mathematical and Simulation Modeling/C.C6.C67 - Input–Output ModelsEconomics and EconometricsJEL: C - Mathematical and Quantitative Methods/C.C6 - Mathematical Methods • Programming Models • Mathematical and Simulation Modeling/C.C6.C67 - Input–Output Modelscausative matrixComputationJEL: D - Microeconomics/D.D5 - General Equilibrium and Disequilibrium/D.D5.D57 - Input–Output Tables and AnalysisStructural difference[SHS.ECO]Humanities and Social Sciences/Economics and Financemathematical economicsinput-output analysisJEL: C - Mathematical and Quantitative Methods/C.C6 - Mathematical Methods • Programming Models • Mathematical and Simulation Modeling/C.C6.C63 - Computational Techniques • Simulation ModelingJEL : C - Mathematical and Quantitative Methods/C.C6 - Mathematical Methods • Programming Models • Mathematical and Simulation Modeling/C.C6.C63 - Computational Techniques • Simulation ModelingbiproportionMedian filterJEL : D - Microeconomics/D.D5 - General Equilibrium and Disequilibrium/D.D5.D57 - Input–Output Tables and Analysis[ SHS.ECO ] Humanities and Social Sciences/Economies and finances[SHS.ECO] Humanities and Social Sciences/Economics and FinanceAlgorithmMathematicsRAS
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Pseudomonas aeruginosa cause epidemic disease in the milkweed bug,Oncopeltus fasciatus dallas (Insecta, Heteroptera)

1976

Pseudomonas aeruginosa was recognized as the causative organism of an epidemic disease occurring in a laboratory breed ofOncopeltus fasciatus. The infection probably occurs peroral and is favoured by high temperature and humidity.Pseudomonas aeruginosa destroys the fat body of the bug.

PharmacologyFat bodybiologyPseudomonas aeruginosaHeteropteraCell Biologybiology.organism_classificationmedicine.disease_causeBreedMicrobiologyCellular and Molecular NeuroscienceCausative organismmedicineMolecular MedicineEpidemic diseaseMolecular BiologyExperientia
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Automatic Extraction of Semantic Roles in Support Verb Constructions

2021

This paper deals with paraphrastic relations in Italian. In the following sentences: (a) Max strappò delle lacrime a Sara 'Max moved Sara to tears' and (b) Max fece piangere Sara 'Max made Sara cry', the verbs differ syntactically and semantically. Strappare 'tear/rip/wring' is transitive, fare ‘have/make’ is a causative, and piangere 'cry' is intransitive. Despite this, a translation of (a) as (b) is legitimate and therefore (a) is a paraphrase of (b). In theoretical linguistics this raises an issue concerning the relationship between strappare and fare/piangere in Italian, and that in English between move and make. In computational linguistics, can such paraphrases be obtained automatical…

Transitive relationSemantic role labelingParaphrase Entailments Meaning Extraction Automatic Detection of Semantic RolesTheoretical linguisticsVerbCausativeComputational linguisticsPsychologyParaphraseLinguisticsSettore L-LIN/01 - Glottologia E LinguisticaInternational Journal on Natural Language Computing
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Unaccusativity

2012

Abstract My research is an attempt at suggesting a cross-linguistically valid definition of verbs characterized by unagentivity and affectedness such as “burn”, “die”, “sink”, “fall”, “slide”, etc., which according to the present analysis constitute the semantic core of unaccusativity. Both synchronic and diachronic approaches are followed. Various definitions have been attributed to these verbs (eventives, anticausatives, transformatives, inchoatives, decausatives). Although Perlmutter & Postal (1984) classify unaccusative verbs on the basis of their syntactic behavior, they also argue that the syntactic expression of arguments is always determinable on the basis of the meaning of the verb…

affectedness of subject activa tantum agentivity anticausatives deponentia ergatives eventives inactivemedia tantum mediality prototypical intransitives prototypical unaccusatives semantic transitivity split intransitivity syntactic transitivity unaccusative hypothesis unaccusatives unagentivity unergativesSettore L-LIN/01 - Glottologia E Linguistica
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On the semantic interpretation of complex causatives in Finnish: An experimental morphology approach

2009

It is well documented that in some languages, such as in Finnish, it is possible to stack derivational morphemes iteratively to word stems. However, such complex words are seldom used in real communication, and it is unclear whether they are interpreted compositionally in tandem with their morphological structure. Here I studied the matter by eliciting semantic interpretations from ten native speakers of Finnish for words whose complexity and morphemic content were systematically varied. The results show that although the frequency of semantic interpretation decreases linearly as a function of the number of morphemes in a word (contrary to the case of ungrammatical words where the semantic …

double causativescausativeslinguistic complexityFinnishmorphologysananmuodostuscomplexity effectindirect causationkompleksisuustriple causatives
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